Comparison of commercial surface-enhanced Raman spectroscopy substrates for the analysis of cocaine.

Alder, R; Xiao, L; Fu, S

Comparison of commercial surface-enhanced Raman spectroscopy substrates for the analysis of cocaine.

Alder, R

Xiao, L Fu, S

Permalink

Publisher:: John Wiley and Sons
Publication Type:: Journal Article
Citation:: Drug Testing and Analysis, 2021, 13, (5), pp. 944-952
Issue Date:: 2021-01-01

Closed Access

	Filename	Description	Size
	Drug Testing and Analysis - 2020 - Alder - Comparison of commercial surface%E2%80%90enhanced Raman spectroscopy substrates for the.pdf		5.38 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Alder, R https://orcid.org/0000-0002-1619-1636
dc.contributor.author	Xiao, L
dc.contributor.author	Fu, S https://orcid.org/0000-0002-6238-3612
dc.date.accessioned	2022-01-19T02:04:53Z
dc.date.available	2020-06-30
dc.date.available	2022-01-19T02:04:53Z
dc.date.issued	2021-01-01
dc.identifier.citation	Drug Testing and Analysis, 2021, 13, (5), pp. 944-952
dc.identifier.issn	1942-7603
dc.identifier.issn	1942-7611
dc.identifier.uri	http://hdl.handle.net/10453/153340
dc.description.abstract	The use of illicit drugs across the world causes issues for users, healthcare workers and the public. Therefore, rapid and reliable onsite testing methods to detect these drugs are required. In this study, seven commercial surface-enhanced Raman spectroscopy (SERS) substrates A-G were compared for the analysis of cocaine. These substrates were compared using scanning electron microscopy to study the surface structure and Raman spectroscopy and to determine if there was any enhancement of the cocaine bands. Substrate B provided the best enhancement of known cocaine vibrational bands, allowing the detection down to concentrations of 1 ng/mL in standards and 10 ng/mL extracted from the oral fluid. The results showed that SERS is an ideal method for future rapid onsite analysis of illicit drugs in oral fluid. Commercial SERS substrates were compared for the analysis of cocaine. Substrate B provided the best result and was further tested with lower concentrations and extracts from the oral fluid. The application to oral fluid testing could prove useful for future onsite analysis.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	John Wiley and Sons
dc.relation.ispartof	Drug Testing and Analysis
dc.relation.isbasedon	10.1002/dta.2894
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0301 Analytical Chemistry, 0601 Biochemistry and Cell Biology, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Analytical Chemistry
dc.subject.mesh	Central Nervous System Stimulants
dc.subject.mesh	Cocaine
dc.subject.mesh	Cocaine-Related Disorders
dc.subject.mesh	Humans
dc.subject.mesh	Predictive Value of Tests
dc.subject.mesh	Reproducibility of Results
dc.subject.mesh	Saliva
dc.subject.mesh	Spectrum Analysis, Raman
dc.subject.mesh	Substance Abuse Detection
dc.subject.mesh	Saliva
dc.subject.mesh	Humans
dc.subject.mesh	Cocaine-Related Disorders
dc.subject.mesh	Cocaine
dc.subject.mesh	Central Nervous System Stimulants
dc.subject.mesh	Spectrum Analysis, Raman
dc.subject.mesh	Reproducibility of Results
dc.subject.mesh	Predictive Value of Tests
dc.subject.mesh	Substance Abuse Detection
dc.title	Comparison of commercial surface-enhanced Raman spectroscopy substrates for the analysis of cocaine.
dc.type	Journal Article
utslib.citation.volume	13
utslib.location.activity	England
utslib.for	0301 Analytical Chemistry
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
utslib.copyright.status	closed_access	*
pubs.consider-herdc	true
dc.date.updated	2022-01-19T02:04:50Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	13
utslib.citation.issue	5

Abstract:

The use of illicit drugs across the world causes issues for users, healthcare workers and the public. Therefore, rapid and reliable onsite testing methods to detect these drugs are required. In this study, seven commercial surface-enhanced Raman spectroscopy (SERS) substrates A-G were compared for the analysis of cocaine. These substrates were compared using scanning electron microscopy to study the surface structure and Raman spectroscopy and to determine if there was any enhancement of the cocaine bands. Substrate B provided the best enhancement of known cocaine vibrational bands, allowing the detection down to concentrations of 1 ng/mL in standards and 10 ng/mL extracted from the oral fluid. The results showed that SERS is an ideal method for future rapid onsite analysis of illicit drugs in oral fluid. Commercial SERS substrates were compared for the analysis of cocaine. Substrate B provided the best result and was further tested with lower concentrations and extracts from the oral fluid. The application to oral fluid testing could prove useful for future onsite analysis.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/153340