Comparison of commercial surface-enhanced Raman spectroscopy substrates for the analysis of cocaine.
- Publisher:
- John Wiley and Sons
- Publication Type:
- Journal Article
- Citation:
- Drug Testing and Analysis, 2021, 13, (5), pp. 944-952
- Issue Date:
- 2021-01-01
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Drug Testing and Analysis - 2020 - Alder - Comparison of commercial surface%E2%80%90enhanced Raman spectroscopy substrates for the.pdf | 5.38 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author |
Alder, R https://orcid.org/0000-0002-1619-1636 |
|
dc.contributor.author | Xiao, L | |
dc.contributor.author |
Fu, S https://orcid.org/0000-0002-6238-3612 |
|
dc.date.accessioned | 2022-01-19T02:04:53Z | |
dc.date.available | 2020-06-30 | |
dc.date.available | 2022-01-19T02:04:53Z | |
dc.date.issued | 2021-01-01 | |
dc.identifier.citation | Drug Testing and Analysis, 2021, 13, (5), pp. 944-952 | |
dc.identifier.issn | 1942-7603 | |
dc.identifier.issn | 1942-7611 | |
dc.identifier.uri | http://hdl.handle.net/10453/153340 | |
dc.description.abstract | The use of illicit drugs across the world causes issues for users, healthcare workers and the public. Therefore, rapid and reliable onsite testing methods to detect these drugs are required. In this study, seven commercial surface-enhanced Raman spectroscopy (SERS) substrates A-G were compared for the analysis of cocaine. These substrates were compared using scanning electron microscopy to study the surface structure and Raman spectroscopy and to determine if there was any enhancement of the cocaine bands. Substrate B provided the best enhancement of known cocaine vibrational bands, allowing the detection down to concentrations of 1 ng/mL in standards and 10 ng/mL extracted from the oral fluid. The results showed that SERS is an ideal method for future rapid onsite analysis of illicit drugs in oral fluid. Commercial SERS substrates were compared for the analysis of cocaine. Substrate B provided the best result and was further tested with lower concentrations and extracts from the oral fluid. The application to oral fluid testing could prove useful for future onsite analysis. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | John Wiley and Sons | |
dc.relation.ispartof | Drug Testing and Analysis | |
dc.relation.isbasedon | 10.1002/dta.2894 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 0301 Analytical Chemistry, 0601 Biochemistry and Cell Biology, 1115 Pharmacology and Pharmaceutical Sciences | |
dc.subject.classification | Analytical Chemistry | |
dc.subject.mesh | Central Nervous System Stimulants | |
dc.subject.mesh | Cocaine | |
dc.subject.mesh | Cocaine-Related Disorders | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Predictive Value of Tests | |
dc.subject.mesh | Reproducibility of Results | |
dc.subject.mesh | Saliva | |
dc.subject.mesh | Spectrum Analysis, Raman | |
dc.subject.mesh | Substance Abuse Detection | |
dc.subject.mesh | Saliva | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Cocaine-Related Disorders | |
dc.subject.mesh | Cocaine | |
dc.subject.mesh | Central Nervous System Stimulants | |
dc.subject.mesh | Spectrum Analysis, Raman | |
dc.subject.mesh | Reproducibility of Results | |
dc.subject.mesh | Predictive Value of Tests | |
dc.subject.mesh | Substance Abuse Detection | |
dc.title | Comparison of commercial surface-enhanced Raman spectroscopy substrates for the analysis of cocaine. | |
dc.type | Journal Article | |
utslib.citation.volume | 13 | |
utslib.location.activity | England | |
utslib.for | 0301 Analytical Chemistry | |
utslib.for | 0601 Biochemistry and Cell Biology | |
utslib.for | 1115 Pharmacology and Pharmaceutical Sciences | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Strength - CFS - Centre for Forensic Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences | |
pubs.organisational-group | /University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology | |
utslib.copyright.status | closed_access | * |
pubs.consider-herdc | true | |
dc.date.updated | 2022-01-19T02:04:50Z | |
pubs.issue | 5 | |
pubs.publication-status | Published | |
pubs.volume | 13 | |
utslib.citation.issue | 5 |
Abstract:
The use of illicit drugs across the world causes issues for users, healthcare workers and the public. Therefore, rapid and reliable onsite testing methods to detect these drugs are required. In this study, seven commercial surface-enhanced Raman spectroscopy (SERS) substrates A-G were compared for the analysis of cocaine. These substrates were compared using scanning electron microscopy to study the surface structure and Raman spectroscopy and to determine if there was any enhancement of the cocaine bands. Substrate B provided the best enhancement of known cocaine vibrational bands, allowing the detection down to concentrations of 1 ng/mL in standards and 10 ng/mL extracted from the oral fluid. The results showed that SERS is an ideal method for future rapid onsite analysis of illicit drugs in oral fluid. Commercial SERS substrates were compared for the analysis of cocaine. Substrate B provided the best result and was further tested with lower concentrations and extracts from the oral fluid. The application to oral fluid testing could prove useful for future onsite analysis.
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