| Field |
Value |
Language |
|
dc.contributor.author |
Keen, B |
|
|
dc.contributor.author |
Cawley, A |
|
|
dc.contributor.author |
Fouracre, C |
|
|
dc.contributor.author |
Pyke, J |
|
|
dc.contributor.author |
Fu, S
https://orcid.org/0000-0002-6238-3612
|
|
|
dc.date.accessioned |
2022-01-19T02:47:27Z |
|
|
dc.date.available |
2021-02-22 |
|
|
dc.date.available |
2022-01-19T02:47:27Z |
|
|
dc.date.issued |
2021-05 |
|
|
dc.identifier.citation |
Drug Testing and Analysis, 2021, 13, (5), pp. 1001-1007 |
|
|
dc.identifier.issn |
1942-7603 |
|
|
dc.identifier.issn |
1942-7611 |
|
|
dc.identifier.uri |
http://hdl.handle.net/10453/153346
|
|
|
dc.description.abstract |
The emergence of novel doping agents is a continuous issue for analysts who aim to maintain the integrity of horseracing together with the well-being and safety of the animals and riders involved. Untargeted mass spectrometric analysis presents a potential improvement for antidoping as it enables the detection of compounds being indirectly affected by an administered drug. In this study, liquid chromatography-high-resolution mass spectrometry was used to investigate a 12-horse administration study of the synthetic opioid, butorphanol. A mass spectrometric workflow capable of detecting metabolic differences for an extended period of time was successfully developed. This proof-of-concept study demonstrates the potential of untargeted workflows to provide a list of biomarkers of exposure and effect that are indicative of drug administration which may be implemented into routine testing for improved doping control. |
|
|
dc.format |
Print-Electronic |
|
|
dc.language |
eng |
|
|
dc.publisher |
John Wiley and Sons |
|
|
dc.relation.ispartof |
Drug Testing and Analysis |
|
|
dc.relation.isbasedon |
10.1002/dta.3021 |
|
|
dc.rights |
info:eu-repo/semantics/openAccess |
|
|
dc.subject |
0301 Analytical Chemistry, 0601 Biochemistry and Cell Biology, 1115 Pharmacology and Pharmaceutical Sciences |
|
|
dc.subject.classification |
Analytical Chemistry |
|
|
dc.subject.mesh |
Analgesics, Opioid |
|
|
dc.subject.mesh |
Animals |
|
|
dc.subject.mesh |
Butorphanol |
|
|
dc.subject.mesh |
Chromatography, High Pressure Liquid |
|
|
dc.subject.mesh |
Data Mining |
|
|
dc.subject.mesh |
Doping in Sports |
|
|
dc.subject.mesh |
Horses |
|
|
dc.subject.mesh |
Male |
|
|
dc.subject.mesh |
Mass Spectrometry |
|
|
dc.subject.mesh |
Proof of Concept Study |
|
|
dc.subject.mesh |
Reproducibility of Results |
|
|
dc.subject.mesh |
Substance Abuse Detection |
|
|
dc.subject.mesh |
Workflow |
|
|
dc.subject.mesh |
Analgesics, Opioid |
|
|
dc.subject.mesh |
Animals |
|
|
dc.subject.mesh |
Butorphanol |
|
|
dc.subject.mesh |
Chromatography, High Pressure Liquid |
|
|
dc.subject.mesh |
Data Mining |
|
|
dc.subject.mesh |
Doping in Sports |
|
|
dc.subject.mesh |
Horses |
|
|
dc.subject.mesh |
Male |
|
|
dc.subject.mesh |
Mass Spectrometry |
|
|
dc.subject.mesh |
Proof of Concept Study |
|
|
dc.subject.mesh |
Reproducibility of Results |
|
|
dc.subject.mesh |
Substance Abuse Detection |
|
|
dc.subject.mesh |
Workflow |
|
|
dc.subject.mesh |
Animals |
|
|
dc.subject.mesh |
Horses |
|
|
dc.subject.mesh |
Butorphanol |
|
|
dc.subject.mesh |
Analgesics, Opioid |
|
|
dc.subject.mesh |
Chromatography, High Pressure Liquid |
|
|
dc.subject.mesh |
Reproducibility of Results |
|
|
dc.subject.mesh |
Substance Abuse Detection |
|
|
dc.subject.mesh |
Doping in Sports |
|
|
dc.subject.mesh |
Male |
|
|
dc.subject.mesh |
Mass Spectrometry |
|
|
dc.subject.mesh |
Workflow |
|
|
dc.subject.mesh |
Data Mining |
|
|
dc.subject.mesh |
Proof of Concept Study |
|
|
dc.title |
Towards an untargeted mass spectrometric approach for improved screening in equine antidoping. |
|
|
dc.type |
Journal Article |
|
|
utslib.citation.volume |
13 |
|
|
utslib.location.activity |
England |
|
|
utslib.for |
0301 Analytical Chemistry |
|
|
utslib.for |
0601 Biochemistry and Cell Biology |
|
|
utslib.for |
1115 Pharmacology and Pharmaceutical Sciences |
|
|
pubs.organisational-group |
/University of Technology Sydney |
|
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Science |
|
|
pubs.organisational-group |
/University of Technology Sydney/Strength - CFS - Centre for Forensic Science |
|
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences |
|
|
pubs.organisational-group |
/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology |
|
|
utslib.copyright.status |
open_access |
* |
|
pubs.consider-herdc |
false |
|
|
dc.date.updated |
2022-01-19T02:47:21Z |
|
|
pubs.issue |
5 |
|
|
pubs.publication-status |
Published |
|
|
pubs.volume |
13 |
|
|
utslib.citation.issue |
5 |
|
