Determinants of Lung Fissure Completeness.

van der Molen, MC; Hartman, JE; Vermeulen, CJ; van den Berge, M; Faiz, A; Kerstjens, HAM; Charbonnier, J-P; Vanfleteren, LEGW; Slebos, D-J

Determinants of Lung Fissure Completeness.

van der Molen, MC Hartman, JE Vermeulen, CJ van den Berge, M Faiz, A

Kerstjens, HAM Charbonnier, J-P Vanfleteren, LEGW Slebos, D-J

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Publisher:: AMER THORACIC SOC
Publication Type:: Journal Article
Citation:: Am J Respir Crit Care Med, 2021, 204, (7), pp. 807-816
Issue Date:: 2021-10-01

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Field	Value	Language
dc.contributor.author	van der Molen, MC
dc.contributor.author	Hartman, JE
dc.contributor.author	Vermeulen, CJ
dc.contributor.author	van den Berge, M
dc.contributor.author	Faiz, A https://orcid.org/0000-0003-1740-3538
dc.contributor.author	Kerstjens, HAM
dc.contributor.author	Charbonnier, J-P
dc.contributor.author	Vanfleteren, LEGW
dc.contributor.author	Slebos, D-J
dc.date.accessioned	2022-01-29T19:34:52Z
dc.date.available	2022-01-29T19:34:52Z
dc.date.issued	2021-10-01
dc.identifier.citation	Am J Respir Crit Care Med, 2021, 204, (7), pp. 807-816
dc.identifier.issn	1073-449X
dc.identifier.issn	1535-4970
dc.identifier.uri	http://hdl.handle.net/10453/153809
dc.description.abstract	Rationale: New advanced bronchoscopic treatment options for patients with severe chronic obstructive pulmonary disease (COPD) have led to increased interest for COPD phenotyping, including fissure completeness. Objectives: We investigated clinical, environmental, and genetic factors contributing to fissure completeness in patients with and without COPD. Methods: We used data from 9,926 participants of the COPDGene study who underwent chest computed tomographic (CT) scans. Fissure completeness was calculated from CT scans after quantitative CT analysis at baseline and 5-year follow-up. Clinical and environmental factors, including sex, race, smoking, COPD, emphysema, maternal smoking during pregnancy and maternal COPD, were tested for impact on fissure completeness. Genome-wide association analyses were performed separately in non-Hispanic White subjects and African American subjects. Measurements and Main Results: African American subjects had significantly higher fissure completeness than non-Hispanic White subjects for all three fissures (P < 0.001). There was no change in fissure completeness between baseline and 5-year follow-up. For all fissures, no clinically relevant differences in fissure completeness were found for other clinical or environmental factors, including COPD severity. Rs2173623, rs264866, rs2407284, rs7310342, rs4904145, rs6504172, and rs7209556 showed genome-wide significant associations with fissure completeness in non-Hispanic White subjects. In African American subjects, rs264866, rs4904145 and rs6504172 were identified as significant associations. Rs2173623, rs6504172, and rs7209556 lead to WNT5A and HOXB antisense RNA expression, which play an important role during embryogenesis. Conclusions: Fissure completeness is genetically determined and not dependent on age, sex, smoking status, the presence and severity of COPD (including exacerbation frequency), maternal smoking during pregnancy, or maternal COPD.
dc.format	Print
dc.language	eng
dc.publisher	AMER THORACIC SOC
dc.relation.ispartof	Am J Respir Crit Care Med
dc.relation.isbasedon	10.1164/rccm.202102-0260OC
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	11 Medical and Health Sciences
dc.subject.classification	Respiratory System
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Case-Control Studies
dc.subject.mesh	Ethnicity
dc.subject.mesh	Female
dc.subject.mesh	Follow-Up Studies
dc.subject.mesh	Genetic Markers
dc.subject.mesh	Genetic Predisposition to Disease
dc.subject.mesh	Genome-Wide Association Study
dc.subject.mesh	Genotyping Techniques
dc.subject.mesh	Humans
dc.subject.mesh	Linear Models
dc.subject.mesh	Lung
dc.subject.mesh	Male
dc.subject.mesh	Middle Aged
dc.subject.mesh	Polymorphism, Single Nucleotide
dc.subject.mesh	Pulmonary Disease, Chronic Obstructive
dc.subject.mesh	Tomography, X-Ray Computed
dc.subject.mesh	Lung
dc.subject.mesh	Humans
dc.subject.mesh	Pulmonary Disease, Chronic Obstructive
dc.subject.mesh	Genetic Predisposition to Disease
dc.subject.mesh	Genetic Markers
dc.subject.mesh	Tomography, X-Ray Computed
dc.subject.mesh	Linear Models
dc.subject.mesh	Case-Control Studies
dc.subject.mesh	Follow-Up Studies
dc.subject.mesh	Polymorphism, Single Nucleotide
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Ethnic Groups
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Genome-Wide Association Study
dc.subject.mesh	Genotyping Techniques
dc.title	Determinants of Lung Fissure Completeness.
dc.type	Journal Article
utslib.citation.volume	204
utslib.location.activity	United States
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	closed_access	*
dc.date.updated	2022-01-29T19:34:47Z
pubs.issue	7
pubs.publication-status	Published
pubs.volume	204
utslib.citation.issue	7

Abstract:

Rationale: New advanced bronchoscopic treatment options for patients with severe chronic obstructive pulmonary disease (COPD) have led to increased interest for COPD phenotyping, including fissure completeness. Objectives: We investigated clinical, environmental, and genetic factors contributing to fissure completeness in patients with and without COPD. Methods: We used data from 9,926 participants of the COPDGene study who underwent chest computed tomographic (CT) scans. Fissure completeness was calculated from CT scans after quantitative CT analysis at baseline and 5-year follow-up. Clinical and environmental factors, including sex, race, smoking, COPD, emphysema, maternal smoking during pregnancy and maternal COPD, were tested for impact on fissure completeness. Genome-wide association analyses were performed separately in non-Hispanic White subjects and African American subjects. Measurements and Main Results: African American subjects had significantly higher fissure completeness than non-Hispanic White subjects for all three fissures (P < 0.001). There was no change in fissure completeness between baseline and 5-year follow-up. For all fissures, no clinically relevant differences in fissure completeness were found for other clinical or environmental factors, including COPD severity. Rs2173623, rs264866, rs2407284, rs7310342, rs4904145, rs6504172, and rs7209556 showed genome-wide significant associations with fissure completeness in non-Hispanic White subjects. In African American subjects, rs264866, rs4904145 and rs6504172 were identified as significant associations. Rs2173623, rs6504172, and rs7209556 lead to WNT5A and HOXB antisense RNA expression, which play an important role during embryogenesis. Conclusions: Fissure completeness is genetically determined and not dependent on age, sex, smoking status, the presence and severity of COPD (including exacerbation frequency), maternal smoking during pregnancy, or maternal COPD.

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http://hdl.handle.net/10453/153809