Gasping for Sulfide: A Critical Appraisal of Hydrogen Sulfide in Lung Disease and Accelerated Aging.

Pacitti, D; Scotton, CJ; Kumar, V; Khan, H; Wark, PAB; Torregrossa, R; Hansbro, PM; Whiteman, M

Gasping for Sulfide: A Critical Appraisal of Hydrogen Sulfide in Lung Disease and Accelerated Aging.

Pacitti, D Scotton, CJ Kumar, V Khan, H Wark, PAB Torregrossa, R Hansbro, PM Whiteman, M

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Publisher:: MARY ANN LIEBERT, INC
Publication Type:: Journal Article
Citation:: Antioxid Redox Signal, 2021, 35, (7), pp. 551-579
Issue Date:: 2021-09-01

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Field	Value	Language
dc.contributor.author	Pacitti, D
dc.contributor.author	Scotton, CJ
dc.contributor.author	Kumar, V
dc.contributor.author	Khan, H
dc.contributor.author	Wark, PAB
dc.contributor.author	Torregrossa, R
dc.contributor.author	Hansbro, PM
dc.contributor.author	Whiteman, M
dc.date.accessioned	2022-02-02T20:52:25Z
dc.date.available	2022-02-02T20:52:25Z
dc.date.issued	2021-09-01
dc.identifier.citation	Antioxid Redox Signal, 2021, 35, (7), pp. 551-579
dc.identifier.issn	1523-0864
dc.identifier.issn	1557-7716
dc.identifier.uri	http://hdl.handle.net/10453/154145
dc.description.abstract	Hydrogen sulfide (H2S) is a gaseous signaling molecule involved in a plethora of physiological and pathological processes. It is primarily synthesized by cystathionine-β-synthase, cystathionine-γ-lyase, and 3-mercaptopyruvate sulfurtransferase as a metabolite of the transsulfuration pathway. H2S has been shown to exert beneficial roles in lung disease acting as an anti-inflammatory and antiviral and to ameliorate cell metabolism and protect from oxidative stress. H2S interacts with transcription factors, ion channels, and a multitude of proteins via post-translational modifications through S-persulfidation ("sulfhydration"). Perturbation of endogenous H2S synthesis and/or levels have been implicated in the development of accelerated lung aging and diseases, including asthma, chronic obstructive pulmonary disease, and fibrosis. Furthermore, evidence indicates that persulfidation is decreased with aging. Here, we review the use of H2S as a biomarker of lung pathologies and discuss the potential of using H2S-generating molecules and synthesis inhibitors to treat respiratory diseases. Furthermore, we provide a critical appraisal of methods of detection used to quantify H2S concentration in biological samples and discuss the challenges of characterizing physiological and pathological levels. Considerations and caveats of using H2S delivery molecules, the choice of generating molecules, and concentrations are also reviewed. Antioxid. Redox Signal. 35, 551-579.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	MARY ANN LIEBERT, INC
dc.relation.ispartof	Antioxid Redox Signal
dc.relation.isbasedon	10.1089/ars.2021.0039
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology, 1101 Medical Biochemistry and Metabolomics, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Biochemistry & Molecular Biology
dc.title	Gasping for Sulfide: A Critical Appraisal of Hydrogen Sulfide in Lung Disease and Accelerated Aging.
dc.type	Journal Article
utslib.citation.volume	35
utslib.location.activity	United States
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1101 Medical Biochemistry and Metabolomics
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2022-02-02T20:52:24Z
pubs.issue	7
pubs.publication-status	Published
pubs.volume	35
utslib.citation.issue	7

Abstract:

Hydrogen sulfide (H2S) is a gaseous signaling molecule involved in a plethora of physiological and pathological processes. It is primarily synthesized by cystathionine-β-synthase, cystathionine-γ-lyase, and 3-mercaptopyruvate sulfurtransferase as a metabolite of the transsulfuration pathway. H2S has been shown to exert beneficial roles in lung disease acting as an anti-inflammatory and antiviral and to ameliorate cell metabolism and protect from oxidative stress. H2S interacts with transcription factors, ion channels, and a multitude of proteins via post-translational modifications through S-persulfidation ("sulfhydration"). Perturbation of endogenous H2S synthesis and/or levels have been implicated in the development of accelerated lung aging and diseases, including asthma, chronic obstructive pulmonary disease, and fibrosis. Furthermore, evidence indicates that persulfidation is decreased with aging. Here, we review the use of H2S as a biomarker of lung pathologies and discuss the potential of using H2S-generating molecules and synthesis inhibitors to treat respiratory diseases. Furthermore, we provide a critical appraisal of methods of detection used to quantify H2S concentration in biological samples and discuss the challenges of characterizing physiological and pathological levels. Considerations and caveats of using H2S delivery molecules, the choice of generating molecules, and concentrations are also reviewed. Antioxid. Redox Signal. 35, 551-579.

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http://hdl.handle.net/10453/154145