Ultraefficiently Calming Cytokine Storm Using Ti3 C2 Tx MXene.

Wang, T; Sun, X; Guo, X; Zhang, J; Yang, J; Tao, S; Guan, J; Zhou, L; Han, J; Wang, C; Yao, H; Wang, G

Ultraefficiently Calming Cytokine Storm Using Ti3 C2 Tx MXene.

Wang, T Sun, X Guo, X

Zhang, J Yang, J

Tao, S Guan, J Zhou, L Han, J Wang, C Yao, H Wang, G

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Publisher:: Wiley-Blackwell
Publication Type:: Journal Article
Citation:: Small Methods, 2021, 5, (5), pp. 1-10
Issue Date:: 2021-05

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Field	Value	Language
dc.contributor.author	Wang, T
dc.contributor.author	Sun, X
dc.contributor.author	Guo, X https://orcid.org/0000-0001-7771-0463
dc.contributor.author	Zhang, J
dc.contributor.author	Yang, J https://orcid.org/0000-0002-7507-6929
dc.contributor.author	Tao, S
dc.contributor.author	Guan, J
dc.contributor.author	Zhou, L
dc.contributor.author	Han, J
dc.contributor.author	Wang, C
dc.contributor.author	Yao, H
dc.contributor.author	Wang, G https://orcid.org/0000-0003-4295-8578
dc.date.accessioned	2022-02-08T02:34:34Z
dc.date.available	2022-02-08T02:34:34Z
dc.date.issued	2021-05
dc.identifier.citation	Small Methods, 2021, 5, (5), pp. 1-10
dc.identifier.issn	2366-9608
dc.identifier.issn	2366-9608
dc.identifier.uri	http://hdl.handle.net/10453/154269
dc.description.abstract	During the global outbreak of COVID-19 pandemic, "cytokine storm" conditions are regarded as the fatal step resulting in most mortality. Hemoperfusion is widely used to remove cytokines from the blood of severely ill patients to prevent uncontrolled inflammation induced by a cytokine storm. This article discoveres, for the first time, that 2D Ti3 C2 Tx MXene sheet demonstrates an ultrahigh removal capability for typical cytokine interleukin-6. In particular, MXene shows a 13.4 times higher removal efficiency over traditional activated carbon absorbents. Molecular-level investigations reveal that MXene exhibits a strong chemisorption mechanism for immobilizing cytokine interleukin-6 molecules, which is different from activated carbon absorbents. MXene sheet also demonstrates excellent blood compatibility without any deleterious side influence on the composition of human blood. This work can open a new avenue to use MXene sheets as an ultraefficient hemoperfusion absorbent to eliminate the cytokine storm syndrome in treatment of severe COVID-19 patients.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley-Blackwell
dc.relation.ispartof	Small Methods
dc.relation.isbasedon	10.1002/smtd.202001108
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.mesh	Adsorption
dc.subject.mesh	COVID-19
dc.subject.mesh	Cytokine Release Syndrome
dc.subject.mesh	Hemoperfusion
dc.subject.mesh	Humans
dc.subject.mesh	Interleukin-6
dc.subject.mesh	Nanostructures
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Titanium
dc.subject.mesh	Adsorption
dc.subject.mesh	COVID-19
dc.subject.mesh	Cytokine Release Syndrome
dc.subject.mesh	Hemoperfusion
dc.subject.mesh	Humans
dc.subject.mesh	Interleukin-6
dc.subject.mesh	Nanostructures
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Titanium
dc.subject.mesh	Humans
dc.subject.mesh	Titanium
dc.subject.mesh	Interleukin-6
dc.subject.mesh	Hemoperfusion
dc.subject.mesh	Adsorption
dc.subject.mesh	Nanostructures
dc.subject.mesh	Cytokine Release Syndrome
dc.subject.mesh	COVID-19
dc.subject.mesh	SARS-CoV-2
dc.title	Ultraefficiently Calming Cytokine Storm Using Ti3 C2 Tx MXene.
dc.type	Journal Article
utslib.citation.volume	5
utslib.location.activity	Germany
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Arts and Social Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-02-08T02:34:32Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	5
utslib.citation.issue	5

Abstract:

During the global outbreak of COVID-19 pandemic, "cytokine storm" conditions are regarded as the fatal step resulting in most mortality. Hemoperfusion is widely used to remove cytokines from the blood of severely ill patients to prevent uncontrolled inflammation induced by a cytokine storm. This article discoveres, for the first time, that 2D Ti3 C2 Tx MXene sheet demonstrates an ultrahigh removal capability for typical cytokine interleukin-6. In particular, MXene shows a 13.4 times higher removal efficiency over traditional activated carbon absorbents. Molecular-level investigations reveal that MXene exhibits a strong chemisorption mechanism for immobilizing cytokine interleukin-6 molecules, which is different from activated carbon absorbents. MXene sheet also demonstrates excellent blood compatibility without any deleterious side influence on the composition of human blood. This work can open a new avenue to use MXene sheets as an ultraefficient hemoperfusion absorbent to eliminate the cytokine storm syndrome in treatment of severe COVID-19 patients.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/154269