Recent Progress in DNA Hybridization Chain Reaction Strategies for Amplified Biosensing.

Chai, H; Cheng, W; Jin, D; Miao, P

Recent Progress in DNA Hybridization Chain Reaction Strategies for Amplified Biosensing.

Chai, H Cheng, W Jin, D

Miao, P

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Publisher:: American Chemical Society
Publication Type:: Journal Article
Citation:: ACS Applied Materials and Interfaces, 2021, 13, (33), pp. 38931-38946
Issue Date:: 2021-08-25

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Field	Value	Language
dc.contributor.author	Chai, H
dc.contributor.author	Cheng, W
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666
dc.contributor.author	Miao, P
dc.date.accessioned	2022-02-09T04:08:22Z
dc.date.available	2022-02-09T04:08:22Z
dc.date.issued	2021-08-25
dc.identifier.citation	ACS Applied Materials and Interfaces, 2021, 13, (33), pp. 38931-38946
dc.identifier.issn	1944-8244
dc.identifier.issn	1944-8252
dc.identifier.uri	http://hdl.handle.net/10453/154336
dc.description.abstract	With the continuous development of DNA nanotechnology, various spatial DNA structures and assembly techniques emerge. Hybridization chain reaction (HCR) is a typical example with exciting features and bright prospects in biosensing, which has been intensively investigated in the past decade. In this Spotlight on Applications, we summarize the assembly principles of conventional HCR and some novel forms of linear/nonlinear HCR. With advantages like great assembly kinetics, facile operation, and an enzyme-free and isothermal reaction, these strategies can be integrated with most mainstream reporters (e.g., fluorescence, electrochemistry, and colorimetry) for the ultrasensitive detection of abundant targets. Particularly, we select several representative studies to better illustrate the novel ideas and performances of HCR strategies. Theoretical and practical utilities are confirmed for a range of biosensing applications. In the end, a deep discussion is provided about the challenges and future tasks of this field.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	American Chemical Society
dc.relation.ispartof	ACS Applied Materials and Interfaces
dc.relation.isbasedon	10.1021/acsami.1c09000
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	03 Chemical Sciences, 09 Engineering
dc.subject.classification	Nanoscience & Nanotechnology
dc.subject.mesh	Biosensing Techniques
dc.subject.mesh	Colorimetry
dc.subject.mesh	DNA
dc.subject.mesh	Electrochemical Techniques
dc.subject.mesh	Humans
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Nucleic Acid Amplification Techniques
dc.subject.mesh	Nucleic Acid Conformation
dc.subject.mesh	Nucleic Acid Hybridization
dc.subject.mesh	Sensitivity and Specificity
dc.subject.mesh	Spectrometry, Fluorescence
dc.subject.mesh	Biosensing Techniques
dc.subject.mesh	Colorimetry
dc.subject.mesh	DNA
dc.subject.mesh	Electrochemical Techniques
dc.subject.mesh	Humans
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Nucleic Acid Amplification Techniques
dc.subject.mesh	Nucleic Acid Conformation
dc.subject.mesh	Nucleic Acid Hybridization
dc.subject.mesh	Sensitivity and Specificity
dc.subject.mesh	Spectrometry, Fluorescence
dc.subject.mesh	Humans
dc.subject.mesh	DNA
dc.subject.mesh	Spectrometry, Fluorescence
dc.subject.mesh	Colorimetry
dc.subject.mesh	Sensitivity and Specificity
dc.subject.mesh	Nucleic Acid Amplification Techniques
dc.subject.mesh	Nucleic Acid Hybridization
dc.subject.mesh	Biosensing Techniques
dc.subject.mesh	Nucleic Acid Conformation
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Electrochemical Techniques
dc.title	Recent Progress in DNA Hybridization Chain Reaction Strategies for Amplified Biosensing.
dc.type	Journal Article
utslib.citation.volume	13
utslib.location.activity	United States
utslib.for	03 Chemical Sciences
utslib.for	09 Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-02-09T04:08:15Z
pubs.issue	33
pubs.publication-status	Published
pubs.volume	13
utslib.citation.issue	33

Abstract:

With the continuous development of DNA nanotechnology, various spatial DNA structures and assembly techniques emerge. Hybridization chain reaction (HCR) is a typical example with exciting features and bright prospects in biosensing, which has been intensively investigated in the past decade. In this Spotlight on Applications, we summarize the assembly principles of conventional HCR and some novel forms of linear/nonlinear HCR. With advantages like great assembly kinetics, facile operation, and an enzyme-free and isothermal reaction, these strategies can be integrated with most mainstream reporters (e.g., fluorescence, electrochemistry, and colorimetry) for the ultrasensitive detection of abundant targets. Particularly, we select several representative studies to better illustrate the novel ideas and performances of HCR strategies. Theoretical and practical utilities are confirmed for a range of biosensing applications. In the end, a deep discussion is provided about the challenges and future tasks of this field.

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http://hdl.handle.net/10453/154336