Magneto-Electrically Enhanced Intracellular Catalysis of FePt-FeC Heterostructures for Chemodynamic Therapy.
- Publisher:
- Wiley
- Publication Type:
- Journal Article
- Citation:
- Advanced Materials, 2021, 33, (17), pp. 1-10
- Issue Date:
- 2021-04
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Advanced Materials - 2021 - Zhang - Magneto%u2010Electrically Enhanced Intracellular Catalysis of FePt%u2010FeC Heterostructures for.pdf | 3.15 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, H | |
dc.contributor.author | Li, J | |
dc.contributor.author | Chen, Y | |
dc.contributor.author | Wu, J | |
dc.contributor.author | Wang, K | |
dc.contributor.author | Chen, L | |
dc.contributor.author | Wang, Y | |
dc.contributor.author | Jiang, X | |
dc.contributor.author | Liu, Y | |
dc.contributor.author | Wu, Y | |
dc.contributor.author |
Jin, D https://orcid.org/0000-0003-1046-2666 |
|
dc.contributor.author | Bu, W | |
dc.date.accessioned | 2022-02-09T05:17:52Z | |
dc.date.available | 2022-02-09T05:17:52Z | |
dc.date.issued | 2021-04 | |
dc.identifier.citation | Advanced Materials, 2021, 33, (17), pp. 1-10 | |
dc.identifier.issn | 0935-9648 | |
dc.identifier.issn | 1521-4095 | |
dc.identifier.uri | http://hdl.handle.net/10453/154347 | |
dc.description.abstract | Intracellular catalytic reactions can tailor tumor cell plasticity toward high-efficiency treatments, but the application is hindered by the low efficiency of intracellular catalysis. Here, a magneto-electronic approach is developed for efficient intracellular catalysis by inducing eddy currents of FePt-FeC heterostructures in mild alternating magnetic fields (frequency of f = 96 kHz and amplitude of B ≤ 70 mT). Finite element simulation shows a high density of induced charges gathering at the interface of FePt-FeC heterostructure in the alternating magnetic field. As a result, the concentration of an essential coenzyme-β-nicotinamide adenine dinucleotide-in cancer cells is significantly reduced by the enhanced catalytic hydrogenation reaction of FePt-FeC heterostructures under alternating magnetic stimulation, leading to over 80% of senescent cancer cells-a vulnerable phenotype that facilitates further treatment. It is further demonstrated that senescent cancer cells can be efficiently killed by the chemodynamic therapy based on the enhanced Fenton-like reaction. By promoting intracellular catalytic reactions in tumors, this approach may enable precise catalytic tumor treatment. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Wiley | |
dc.relation.ispartof | Advanced Materials | |
dc.relation.isbasedon | 10.1002/adma.202100472 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 02 Physical Sciences, 03 Chemical Sciences, 09 Engineering | |
dc.subject.classification | Nanoscience & Nanotechnology | |
dc.subject.mesh | Catalysis | |
dc.subject.mesh | Hydrogen Peroxide | |
dc.subject.mesh | Intracellular Space | |
dc.subject.mesh | Iron | |
dc.subject.mesh | Magnetic Phenomena | |
dc.subject.mesh | Nanoparticles | |
dc.subject.mesh | Neoplasms | |
dc.subject.mesh | Platinum | |
dc.subject.mesh | Catalysis | |
dc.subject.mesh | Hydrogen Peroxide | |
dc.subject.mesh | Intracellular Space | |
dc.subject.mesh | Iron | |
dc.subject.mesh | Magnetic Phenomena | |
dc.subject.mesh | Nanoparticles | |
dc.subject.mesh | Neoplasms | |
dc.subject.mesh | Platinum | |
dc.subject.mesh | Intracellular Space | |
dc.subject.mesh | Neoplasms | |
dc.subject.mesh | Hydrogen Peroxide | |
dc.subject.mesh | Iron | |
dc.subject.mesh | Platinum | |
dc.subject.mesh | Catalysis | |
dc.subject.mesh | Nanoparticles | |
dc.subject.mesh | Magnetic Phenomena | |
dc.title | Magneto-Electrically Enhanced Intracellular Catalysis of FePt-FeC Heterostructures for Chemodynamic Therapy. | |
dc.type | Journal Article | |
utslib.citation.volume | 33 | |
utslib.location.activity | Germany | |
utslib.for | 02 Physical Sciences | |
utslib.for | 03 Chemical Sciences | |
utslib.for | 09 Engineering | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences | |
pubs.organisational-group | /University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
utslib.copyright.status | closed_access | * |
pubs.consider-herdc | false | |
dc.date.updated | 2022-02-09T05:17:47Z | |
pubs.issue | 17 | |
pubs.publication-status | Published | |
pubs.volume | 33 | |
utslib.citation.issue | 17 |
Abstract:
Intracellular catalytic reactions can tailor tumor cell plasticity toward high-efficiency treatments, but the application is hindered by the low efficiency of intracellular catalysis. Here, a magneto-electronic approach is developed for efficient intracellular catalysis by inducing eddy currents of FePt-FeC heterostructures in mild alternating magnetic fields (frequency of f = 96 kHz and amplitude of B ≤ 70 mT). Finite element simulation shows a high density of induced charges gathering at the interface of FePt-FeC heterostructure in the alternating magnetic field. As a result, the concentration of an essential coenzyme-β-nicotinamide adenine dinucleotide-in cancer cells is significantly reduced by the enhanced catalytic hydrogenation reaction of FePt-FeC heterostructures under alternating magnetic stimulation, leading to over 80% of senescent cancer cells-a vulnerable phenotype that facilitates further treatment. It is further demonstrated that senescent cancer cells can be efficiently killed by the chemodynamic therapy based on the enhanced Fenton-like reaction. By promoting intracellular catalytic reactions in tumors, this approach may enable precise catalytic tumor treatment.
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