Extracellular vesicles, from pathogenesis to biomarkers: The case for cerebral malaria

Cheng, IS; Sealy, BC; Tiberti, N; Combes, V

Extracellular vesicles, from pathogenesis to biomarkers: The case for cerebral malaria

Cheng, IS Sealy, BC Tiberti, N Combes, V

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Publisher:: OAE Publishing Inc.
Publication Type:: Journal Article
Citation:: Vessel Plus, 2020, 4
Issue Date:: 2020-01-01

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Field	Value	Language
dc.contributor.author	Cheng, IS
dc.contributor.author	Sealy, BC
dc.contributor.author	Tiberti, N
dc.contributor.author	Combes, V https://orcid.org/0000-0003-2178-3596
dc.date.accessioned	2022-02-11T03:46:23Z
dc.date.available	2022-02-11T03:46:23Z
dc.date.issued	2020-01-01
dc.identifier.citation	Vessel Plus, 2020, 4
dc.identifier.issn	2574-1209
dc.identifier.issn	2574-1209
dc.identifier.uri	http://hdl.handle.net/10453/154398
dc.description.abstract	Malaria infections due to the Plasmodium parasite remains a major global health problem. Plasmodium falciparum is responsible for majority of the severe cases, resulting in more than 400,000 deaths per annum . Extracellular vesicles (EVs) released by vascular cells, including parasitised erythrocytes, have been detected with increased levels in patients with malaria. EVs are thought to be involved in the pathogenesis of severe malaria, particularly cerebral malaria, and represent a unique molecular signature for different forms of the infection. In this review, we will cover the known effects of EVs on the vasculature and discuss their potential use as a biomarker of disease severity.
dc.language	en
dc.publisher	OAE Publishing Inc.
dc.relation.ispartof	Vessel Plus
dc.relation.isbasedon	10.20517/2574-1209.2020.08
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Extracellular vesicles, from pathogenesis to biomarkers: The case for cerebral malaria
dc.type	Journal Article
utslib.citation.volume	4
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2022-02-11T03:46:22Z
pubs.publication-status	Published
pubs.volume	4

Abstract:

Malaria infections due to the Plasmodium parasite remains a major global health problem. Plasmodium falciparum is responsible for majority of the severe cases, resulting in more than 400,000 deaths per annum . Extracellular vesicles (EVs) released by vascular cells, including parasitised erythrocytes, have been detected with increased levels in patients with malaria. EVs are thought to be involved in the pathogenesis of severe malaria, particularly cerebral malaria, and represent a unique molecular signature for different forms of the infection. In this review, we will cover the known effects of EVs on the vasculature and discuss their potential use as a biomarker of disease severity.

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http://hdl.handle.net/10453/154398