Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum.
Persinoti, GF
Martinez, DA
Li, W
Döğen, A
Billmyre, RB
Averette, A
Goldberg, JM
Shea, T
Young, S
Zeng, Q
Oliver, BG
Barton, R
Metin, B
Hilmioğlu-Polat, S
Ilkit, M
Gräser, Y
Martinez-Rossi, NM
White, TC
Heitman, J
Cuomo, CA
- Publisher:
- GENETICS SOCIETY AMERICA
- Publication Type:
- Journal Article
- Citation:
- Genetics, 2018, 208, (4), pp. 1657-1669
- Issue Date:
- 2018-04
Closed Access
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Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton ru.pdf | 1.25 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Persinoti, GF | |
dc.contributor.author | Martinez, DA | |
dc.contributor.author | Li, W | |
dc.contributor.author | Döğen, A | |
dc.contributor.author | Billmyre, RB | |
dc.contributor.author | Averette, A | |
dc.contributor.author | Goldberg, JM | |
dc.contributor.author | Shea, T | |
dc.contributor.author | Young, S | |
dc.contributor.author | Zeng, Q | |
dc.contributor.author | Oliver, BG | |
dc.contributor.author | Barton, R | |
dc.contributor.author | Metin, B | |
dc.contributor.author | Hilmioğlu-Polat, S | |
dc.contributor.author | Ilkit, M | |
dc.contributor.author | Gräser, Y | |
dc.contributor.author | Martinez-Rossi, NM | |
dc.contributor.author | White, TC | |
dc.contributor.author | Heitman, J | |
dc.contributor.author | Cuomo, CA | |
dc.date.accessioned | 2022-02-15T05:25:52Z | |
dc.date.available | 2018-02-07 | |
dc.date.available | 2022-02-15T05:25:52Z | |
dc.date.issued | 2018-04 | |
dc.identifier.citation | Genetics, 2018, 208, (4), pp. 1657-1669 | |
dc.identifier.issn | 0016-6731 | |
dc.identifier.issn | 1943-2631 | |
dc.identifier.uri | http://hdl.handle.net/10453/154533 | |
dc.description.abstract | Dermatophytes include fungal species that infect humans, as well as those that also infect other animals or only grow in the environment. The dermatophyte species Trichophyton rubrum is a frequent cause of skin infection in immunocompetent individuals. While members of the T. rubrum species complex have been further categorized based on various morphologies, their population structure and ability to undergo sexual reproduction are not well understood. In this study, we analyze a large set of T. rubrum and T. interdigitale isolates to examine mating types, evidence of mating, and genetic variation. We find that nearly all isolates of T. rubrum are of a single mating type, and that incubation with T. rubrum "morphotype" megninii isolates of the other mating type failed to induce sexual development. While the region around the mating type locus is characterized by a higher frequency of SNPs compared to other genomic regions, we find that the population is remarkably clonal, with highly conserved gene content, low levels of variation, and little evidence of recombination. These results support a model of recent transition to asexual growth when this species specialized to growth on human hosts. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | GENETICS SOCIETY AMERICA | |
dc.relation.ispartof | Genetics | |
dc.relation.isbasedon | 10.1534/genetics.117.300573 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 0604 Genetics | |
dc.subject.classification | Developmental Biology | |
dc.subject.mesh | Alleles | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Computational Biology | |
dc.subject.mesh | DNA Copy Number Variations | |
dc.subject.mesh | Genome, Fungal | |
dc.subject.mesh | Genomics | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Linkage Disequilibrium | |
dc.subject.mesh | Multilocus Sequence Typing | |
dc.subject.mesh | Phylogeny | |
dc.subject.mesh | Polymorphism, Single Nucleotide | |
dc.subject.mesh | Recombination, Genetic | |
dc.subject.mesh | Tinea | |
dc.subject.mesh | Trichophyton | |
dc.subject.mesh | Whole Genome Sequencing | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Trichophyton | |
dc.subject.mesh | Tinea | |
dc.subject.mesh | Computational Biology | |
dc.subject.mesh | Genomics | |
dc.subject.mesh | Phylogeny | |
dc.subject.mesh | Recombination, Genetic | |
dc.subject.mesh | Linkage Disequilibrium | |
dc.subject.mesh | Polymorphism, Single Nucleotide | |
dc.subject.mesh | Alleles | |
dc.subject.mesh | Genome, Fungal | |
dc.subject.mesh | DNA Copy Number Variations | |
dc.subject.mesh | Multilocus Sequence Typing | |
dc.subject.mesh | Whole Genome Sequencing | |
dc.title | Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum. | |
dc.type | Journal Article | |
utslib.citation.volume | 208 | |
utslib.location.activity | United States | |
utslib.for | 0604 Genetics | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
pubs.organisational-group | /University of Technology Sydney/Centre for Health Technologies (CHT) | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2022-02-15T05:25:49Z | |
pubs.issue | 4 | |
pubs.publication-status | Published | |
pubs.volume | 208 | |
utslib.citation.issue | 4 |
Abstract:
Dermatophytes include fungal species that infect humans, as well as those that also infect other animals or only grow in the environment. The dermatophyte species Trichophyton rubrum is a frequent cause of skin infection in immunocompetent individuals. While members of the T. rubrum species complex have been further categorized based on various morphologies, their population structure and ability to undergo sexual reproduction are not well understood. In this study, we analyze a large set of T. rubrum and T. interdigitale isolates to examine mating types, evidence of mating, and genetic variation. We find that nearly all isolates of T. rubrum are of a single mating type, and that incubation with T. rubrum "morphotype" megninii isolates of the other mating type failed to induce sexual development. While the region around the mating type locus is characterized by a higher frequency of SNPs compared to other genomic regions, we find that the population is remarkably clonal, with highly conserved gene content, low levels of variation, and little evidence of recombination. These results support a model of recent transition to asexual growth when this species specialized to growth on human hosts.
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