Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum.

Persinoti, GF; Martinez, DA; Li, W; Döğen, A; Billmyre, RB; Averette, A; Goldberg, JM; Shea, T; Young, S; Zeng, Q; Oliver, BG; Barton, R; Metin, B; Hilmioğlu-Polat, S; Ilkit, M; Gräser, Y; Martinez-Rossi, NM; White, TC; Heitman, J; Cuomo, CA

Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum.

Persinoti, GF Martinez, DA Li, W Döğen, A Billmyre, RB Averette, A Goldberg, JM Shea, T Young, S Zeng, Q Oliver, BG Barton, R Metin, B Hilmioğlu-Polat, S Ilkit, M Gräser, Y Martinez-Rossi, NM White, TC Heitman, J Cuomo, CA

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Publisher:: GENETICS SOCIETY AMERICA
Publication Type:: Journal Article
Citation:: Genetics, 2018, 208, (4), pp. 1657-1669
Issue Date:: 2018-04

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Field	Value	Language
dc.contributor.author	Persinoti, GF
dc.contributor.author	Martinez, DA
dc.contributor.author	Li, W
dc.contributor.author	Döğen, A
dc.contributor.author	Billmyre, RB
dc.contributor.author	Averette, A
dc.contributor.author	Goldberg, JM
dc.contributor.author	Shea, T
dc.contributor.author	Young, S
dc.contributor.author	Zeng, Q
dc.contributor.author	Oliver, BG
dc.contributor.author	Barton, R
dc.contributor.author	Metin, B
dc.contributor.author	Hilmioğlu-Polat, S
dc.contributor.author	Ilkit, M
dc.contributor.author	Gräser, Y
dc.contributor.author	Martinez-Rossi, NM
dc.contributor.author	White, TC
dc.contributor.author	Heitman, J
dc.contributor.author	Cuomo, CA
dc.date.accessioned	2022-02-15T05:25:52Z
dc.date.available	2018-02-07
dc.date.available	2022-02-15T05:25:52Z
dc.date.issued	2018-04
dc.identifier.citation	Genetics, 2018, 208, (4), pp. 1657-1669
dc.identifier.issn	0016-6731
dc.identifier.issn	1943-2631
dc.identifier.uri	http://hdl.handle.net/10453/154533
dc.description.abstract	Dermatophytes include fungal species that infect humans, as well as those that also infect other animals or only grow in the environment. The dermatophyte species Trichophyton rubrum is a frequent cause of skin infection in immunocompetent individuals. While members of the T. rubrum species complex have been further categorized based on various morphologies, their population structure and ability to undergo sexual reproduction are not well understood. In this study, we analyze a large set of T. rubrum and T. interdigitale isolates to examine mating types, evidence of mating, and genetic variation. We find that nearly all isolates of T. rubrum are of a single mating type, and that incubation with T. rubrum "morphotype" megninii isolates of the other mating type failed to induce sexual development. While the region around the mating type locus is characterized by a higher frequency of SNPs compared to other genomic regions, we find that the population is remarkably clonal, with highly conserved gene content, low levels of variation, and little evidence of recombination. These results support a model of recent transition to asexual growth when this species specialized to growth on human hosts.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	GENETICS SOCIETY AMERICA
dc.relation.ispartof	Genetics
dc.relation.isbasedon	10.1534/genetics.117.300573
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0604 Genetics
dc.subject.classification	Developmental Biology
dc.subject.mesh	Alleles
dc.subject.mesh	Animals
dc.subject.mesh	Computational Biology
dc.subject.mesh	DNA Copy Number Variations
dc.subject.mesh	Genome, Fungal
dc.subject.mesh	Genomics
dc.subject.mesh	Humans
dc.subject.mesh	Linkage Disequilibrium
dc.subject.mesh	Multilocus Sequence Typing
dc.subject.mesh	Phylogeny
dc.subject.mesh	Polymorphism, Single Nucleotide
dc.subject.mesh	Recombination, Genetic
dc.subject.mesh	Tinea
dc.subject.mesh	Trichophyton
dc.subject.mesh	Whole Genome Sequencing
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Trichophyton
dc.subject.mesh	Tinea
dc.subject.mesh	Computational Biology
dc.subject.mesh	Genomics
dc.subject.mesh	Phylogeny
dc.subject.mesh	Recombination, Genetic
dc.subject.mesh	Linkage Disequilibrium
dc.subject.mesh	Polymorphism, Single Nucleotide
dc.subject.mesh	Alleles
dc.subject.mesh	Genome, Fungal
dc.subject.mesh	DNA Copy Number Variations
dc.subject.mesh	Multilocus Sequence Typing
dc.subject.mesh	Whole Genome Sequencing
dc.title	Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum.
dc.type	Journal Article
utslib.citation.volume	208
utslib.location.activity	United States
utslib.for	0604 Genetics
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	closed_access	*
dc.date.updated	2022-02-15T05:25:49Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	208
utslib.citation.issue	4

Abstract:

Dermatophytes include fungal species that infect humans, as well as those that also infect other animals or only grow in the environment. The dermatophyte species Trichophyton rubrum is a frequent cause of skin infection in immunocompetent individuals. While members of the T. rubrum species complex have been further categorized based on various morphologies, their population structure and ability to undergo sexual reproduction are not well understood. In this study, we analyze a large set of T. rubrum and T. interdigitale isolates to examine mating types, evidence of mating, and genetic variation. We find that nearly all isolates of T. rubrum are of a single mating type, and that incubation with T. rubrum "morphotype" megninii isolates of the other mating type failed to induce sexual development. While the region around the mating type locus is characterized by a higher frequency of SNPs compared to other genomic regions, we find that the population is remarkably clonal, with highly conserved gene content, low levels of variation, and little evidence of recombination. These results support a model of recent transition to asexual growth when this species specialized to growth on human hosts.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/154533