The Characterization of Steam Distillation as an Extraction Method to Extract Volatile Compounds from Prunella vulgaris and the Investigation of Their Anti-Tumorous Effect

Mak, WCK; Walsh, S

The Characterization of Steam Distillation as an Extraction Method to Extract Volatile Compounds from Prunella vulgaris and the Investigation of Their Anti-Tumorous Effect

Mak, WCK Walsh, S

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Publisher:: Scientific Research Publishing
Publication Type:: Journal Article
Citation:: Journal of Biosciences and Medicines, 2021, 9, (8), pp. 120-142
Issue Date:: 2021

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Field	Value	Language
dc.contributor.author	Mak, WCK
dc.contributor.author	Walsh, S https://orcid.org/0000-0002-7033-8547
dc.date.accessioned	2022-02-16T03:18:36Z
dc.date.available	2022-02-16T03:18:36Z
dc.date.issued	2021
dc.identifier.citation	Journal of Biosciences and Medicines, 2021, 9, (8), pp. 120-142
dc.identifier.issn	2327-509X
dc.identifier.issn	2327-509X
dc.identifier.uri	http://hdl.handle.net/10453/154595
dc.description.abstract	Prunella vulgaris (PV) is a perennial plant which is widely grown around the world. It has been widely used as a medicinal treatment for generations. Previous studies showed extracts from this plant had a wide range of therapeutic efficacy, including anti-tumorous effect. However, the volatile organic compounds (VOCs) extracted from it were rarely explored. This paper reports on the characterization of a steam distillation process to extract VOCs in PV and also the anti-tumorous effects of the PV distillate using the tetrazolium-based Cell Counting Kit-8 (CCK-8) as the test agent, when the VOCs were used to treat oral squamous cancer cells, SSC154. It was found that most abundant VOCs came out steadily and continuously for as long as the duration of the steam extraction could extend. However, some compounds such as benzaldehyde did show depletion as the distillation process progressed, while some compounds such as caryophyllene oxide was only sparsely found at the beginning of distillation. The PV distillate was mildly effective in its cytotoxicity to cancer cells SCC154, in a dosage dependent manner.
dc.language	en
dc.publisher	Scientific Research Publishing
dc.relation.ispartof	Journal of Biosciences and Medicines
dc.relation.isbasedon	10.4236/jbm.2021.98011
dc.rights	info:eu-repo/semantics/openAccess
dc.title	The Characterization of Steam Distillation as an Extraction Method to Extract Volatile Compounds from Prunella vulgaris and the Investigation of Their Anti-Tumorous Effect
dc.type	Journal Article
utslib.citation.volume	9
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
pubs.consider-herdc	true
dc.date.updated	2022-02-16T03:18:33Z
pubs.issue	8
pubs.publication-status	Published
pubs.volume	9
utslib.citation.issue	8

Abstract:

Prunella vulgaris (PV) is a perennial plant which is widely grown around the world. It has been widely used as a medicinal treatment for generations. Previous studies showed extracts from this plant had a wide range of therapeutic efficacy, including anti-tumorous effect. However, the volatile organic compounds (VOCs) extracted from it were rarely explored. This paper reports on the characterization of a steam distillation process to extract VOCs in PV and also the anti-tumorous effects of the PV distillate using the tetrazolium-based Cell Counting Kit-8 (CCK-8) as the test agent, when the VOCs were used to treat oral squamous cancer cells, SSC154. It was found that most abundant VOCs came out steadily and continuously for as long as the duration of the steam extraction could extend. However, some compounds such as benzaldehyde did show depletion as the distillation process progressed, while some compounds such as caryophyllene oxide was only sparsely found at the beginning of distillation. The PV distillate was mildly effective in its cytotoxicity to cancer cells SCC154, in a dosage dependent manner.

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http://hdl.handle.net/10453/154595