Impact of reduced uterine perfusion pressure model of preeclampsia on metabolism of placenta, maternal and fetal hearts.
- Publisher:
- NATURE PORTFOLIO
- Publication Type:
- Journal Article
- Citation:
- Sci Rep, 2022, 12, (1), pp. 1111
- Issue Date:
- 2022-01-21
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author |
McClements, L |
|
dc.contributor.author | Richards, C | |
dc.contributor.author | Patel, N | |
dc.contributor.author | Chen, H | |
dc.contributor.author | Sesperez, K | |
dc.contributor.author | Bubb, KJ | |
dc.contributor.author | Karlstaedt, A | |
dc.contributor.author | Aksentijevic, D | |
dc.date.accessioned | 2022-03-24T22:51:23Z | |
dc.date.available | 2021-12-31 | |
dc.date.available | 2022-03-24T22:51:23Z | |
dc.date.issued | 2022-01-21 | |
dc.identifier.citation | Sci Rep, 2022, 12, (1), pp. 1111 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10453/155525 | |
dc.description.abstract | Preeclampsia is a cardiovascular pregnancy complication characterised by new onset hypertension and organ damage or intrauterine growth restriction. It is one of the leading causes of maternal and fetal mortality in pregnancy globally. Short of pre-term delivery of the fetus and placenta, treatment options are limited. Consequently, preeclampsia leads to increased cardiovascular disease risk in both mothers and offspring later in life. Here we aim to examine the impact of the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia on the maternal cardiovascular system, placental and fetal heart metabolism. The surgical RUPP model was induced in pregnant rats by applying silver clips around the aorta and uterine arteries on gestational day 14, resulting in ~ 40% uterine blood flow reduction. The experiment was terminated on gestational day 19 and metabolomic profile of placentae, maternal and fetal hearts analysed using high-resolution 1H NMR spectroscopy. Impairment of uterine perfusion in RUPP rats caused placental and cardiac hypoxia and a series of metabolic adaptations: altered energetics, carbohydrate, lipid and amino acid metabolism of placentae and maternal hearts. Comparatively, the fetal metabolic phenotype was mildly affected. Nevertheless, long-term effects of these changes in both mothers and the offspring should be investigated further in the future. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.relation.ispartof | Sci Rep | |
dc.relation.isbasedon | 10.1038/s41598-022-05120-2 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Blood Pressure | |
dc.subject.mesh | Computer Simulation | |
dc.subject.mesh | Disease Models, Animal | |
dc.subject.mesh | Female | |
dc.subject.mesh | Fetal Heart | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Hypoxia | |
dc.subject.mesh | Metabolomics | |
dc.subject.mesh | Models, Biological | |
dc.subject.mesh | Placenta | |
dc.subject.mesh | Placental Circulation | |
dc.subject.mesh | Pre-Eclampsia | |
dc.subject.mesh | Pregnancy | |
dc.subject.mesh | Proton Magnetic Resonance Spectroscopy | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Uterus | |
dc.subject.mesh | Uterus | |
dc.subject.mesh | Fetal Heart | |
dc.subject.mesh | Placenta | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Pre-Eclampsia | |
dc.subject.mesh | Disease Models, Animal | |
dc.subject.mesh | Pregnancy | |
dc.subject.mesh | Blood Pressure | |
dc.subject.mesh | Placental Circulation | |
dc.subject.mesh | Models, Biological | |
dc.subject.mesh | Computer Simulation | |
dc.subject.mesh | Female | |
dc.subject.mesh | Metabolomics | |
dc.subject.mesh | Proton Magnetic Resonance Spectroscopy | |
dc.subject.mesh | Hypoxia | |
dc.title | Impact of reduced uterine perfusion pressure model of preeclampsia on metabolism of placenta, maternal and fetal hearts. | |
dc.type | Journal Article | |
utslib.citation.volume | 12 | |
utslib.location.activity | England | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
pubs.organisational-group | /University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2022-03-24T22:51:18Z | |
pubs.issue | 1 | |
pubs.publication-status | Published online | |
pubs.volume | 12 | |
utslib.citation.issue | 1 |
Abstract:
Preeclampsia is a cardiovascular pregnancy complication characterised by new onset hypertension and organ damage or intrauterine growth restriction. It is one of the leading causes of maternal and fetal mortality in pregnancy globally. Short of pre-term delivery of the fetus and placenta, treatment options are limited. Consequently, preeclampsia leads to increased cardiovascular disease risk in both mothers and offspring later in life. Here we aim to examine the impact of the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia on the maternal cardiovascular system, placental and fetal heart metabolism. The surgical RUPP model was induced in pregnant rats by applying silver clips around the aorta and uterine arteries on gestational day 14, resulting in ~ 40% uterine blood flow reduction. The experiment was terminated on gestational day 19 and metabolomic profile of placentae, maternal and fetal hearts analysed using high-resolution 1H NMR spectroscopy. Impairment of uterine perfusion in RUPP rats caused placental and cardiac hypoxia and a series of metabolic adaptations: altered energetics, carbohydrate, lipid and amino acid metabolism of placentae and maternal hearts. Comparatively, the fetal metabolic phenotype was mildly affected. Nevertheless, long-term effects of these changes in both mothers and the offspring should be investigated further in the future.
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