Gene-directed enzyme prodrug therapy for prostate cancer in a mouse model that imitates the development of human disease

John Wiley & Sons Ltd
Publication Type:
Journal Article
Journal Of Gene Medicine, 2004, 6 (1), pp. 43 - 54
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Background Gene-directed enzyme prodrug therapy (GDEPT) based on the E. coli enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically adm
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