Animal models used to evaluate anti-osteoarthritis drugs

Smith, MM; Little, CB; Rodgers, K; Ghosh, P

Animal models used to evaluate anti-osteoarthritis drugs

Smith, MM Little, CB Rodgers, K

Ghosh, P

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Publication Type:: Journal Article
Citation:: Pathologie Biologie, 1997, 45 (4), pp. 313 - 320
Issue Date:: 1997-01-01

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Field	Value	Language
dc.contributor.author	Smith, MM	en_US
dc.contributor.author	Little, CB	en_US
dc.contributor.author	Rodgers, K https://orcid.org/0000-0002-3627-9651	en_US
dc.contributor.author	Ghosh, P	en_US
dc.date.issued	1997-01-01	en_US
dc.identifier.citation	Pathologie Biologie, 1997, 45 (4), pp. 313 - 320	en_US
dc.identifier.issn	0369-8114	en_US
dc.identifier.uri	http://hdl.handle.net/10453/15555
dc.description.abstract	Naturally occurring osteoarthritis occurs in a variety of animal species including mice, guinea pigs, dogs and cynomolgus macaques and some of these animals have been used to evaluate the ability of anti-osteoarthritis drugs to reduce synovial inflammation and preserve cartilage integrity. However, the genetically determined animal models of osteoarthritis require the establishement of colonies which may take several years to develop and may be influenced by the strain of animal used and ill-defined environmental factors. On the other hand, the injection of irritants or enzymes into joints, or destabilization by surgical means, can rapidly and reproducibly lead to joint arthropathy and has therefore been more widely used. Although small animals, particularly rats and rabbits, have been the favoured target species, large animals such as dogs and sheep offer many advantages including the opportunity to undertake topographical analysis of joint cartilage and serial aspiration of synovial fluid. Meniscectomy is a common orthopaedic procedure which, in man and animals, is known to lead to osteoarthritis. In the past we have used this technique to induce osteoarthritis in pure bred dogs but more recently we have employed pure bred Merino sheep, which were matched for age, sex and weight. Using this ovine model we have been able to monitor the early and intermediate stages of cartilage metabolism, as well as identify key proteinases responsible for the loss of proteoglycans from these tissues in osteoarthritis. The effects of anti-osteoarthritis drugs on inflammatory mediators and cartilage metabolism has been successfully studied using the ovine model of osteoarthritis.	en_US
dc.relation.ispartof	Pathologie Biologie	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Cartilage, Articular	en_US
dc.subject.mesh	Menisci, Tibial	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Sheep	en_US
dc.subject.mesh	Dogs	en_US
dc.subject.mesh	Rabbits	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Rats	en_US
dc.subject.mesh	Osteoarthritis	en_US
dc.subject.mesh	Disease Models, Animal	en_US
dc.subject.mesh	Postoperative Complications	en_US
dc.subject.mesh	Anti-Inflammatory Agents	en_US
dc.subject.mesh	Drug Evaluation, Preclinical	en_US
dc.title	Animal models used to evaluate anti-osteoarthritis drugs	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	45	en_US
utslib.for	1103 Clinical Sciences	en_US
dc.location.activity	ISI:A1997XB45400009	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	45	en_US

Abstract:

Naturally occurring osteoarthritis occurs in a variety of animal species including mice, guinea pigs, dogs and cynomolgus macaques and some of these animals have been used to evaluate the ability of anti-osteoarthritis drugs to reduce synovial inflammation and preserve cartilage integrity. However, the genetically determined animal models of osteoarthritis require the establishement of colonies which may take several years to develop and may be influenced by the strain of animal used and ill-defined environmental factors. On the other hand, the injection of irritants or enzymes into joints, or destabilization by surgical means, can rapidly and reproducibly lead to joint arthropathy and has therefore been more widely used. Although small animals, particularly rats and rabbits, have been the favoured target species, large animals such as dogs and sheep offer many advantages including the opportunity to undertake topographical analysis of joint cartilage and serial aspiration of synovial fluid. Meniscectomy is a common orthopaedic procedure which, in man and animals, is known to lead to osteoarthritis. In the past we have used this technique to induce osteoarthritis in pure bred dogs but more recently we have employed pure bred Merino sheep, which were matched for age, sex and weight. Using this ovine model we have been able to monitor the early and intermediate stages of cartilage metabolism, as well as identify key proteinases responsible for the loss of proteoglycans from these tissues in osteoarthritis. The effects of anti-osteoarthritis drugs on inflammatory mediators and cartilage metabolism has been successfully studied using the ovine model of osteoarthritis.

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