Bioengineering Strategies for Protein-Based Nanoparticles.

Diaz, D; Care, A; Sunna, A

Bioengineering Strategies for Protein-Based Nanoparticles.

Diaz, D Care, A

Sunna, A

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Genes (Basel), 2018, 9, (7)
Issue Date:: 2018-07-23

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Field	Value	Language
dc.contributor.author	Diaz, D
dc.contributor.author	Care, A https://orcid.org/0000-0002-0035-7961
dc.contributor.author	Sunna, A
dc.date.accessioned	2022-03-25T04:44:14Z
dc.date.available	2018-07-17
dc.date.available	2022-03-25T04:44:14Z
dc.date.issued	2018-07-23
dc.identifier.citation	Genes (Basel), 2018, 9, (7)
dc.identifier.issn	2073-4425
dc.identifier.issn	2073-4425
dc.identifier.uri	http://hdl.handle.net/10453/155564
dc.description.abstract	In recent years, the practical application of protein-based nanoparticles (PNPs) has expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis. PNPs possess unique features that make them attractive as potential platforms for a variety of nanobiotechnological applications. They self-assemble from multiple protein subunits into hollow monodisperse structures; they are highly stable, biocompatible, and biodegradable; and their external components and encapsulation properties can be readily manipulated by chemical or genetic strategies. Moreover, their complex and perfect symmetry have motivated researchers to mimic their properties in order to create de novo protein assemblies. This review focuses on recent advances in the bioengineering and bioconjugation of PNPs and the implementation of synthetic biology concepts to exploit and enhance PNP's intrinsic properties and to impart them with novel functionalities.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	Genes (Basel)
dc.relation.isbasedon	10.3390/genes9070370
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0604 Genetics
dc.title	Bioengineering Strategies for Protein-Based Nanoparticles.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	Switzerland
utslib.for	0604 Genetics
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2022-03-25T04:44:10Z
pubs.issue	7
pubs.publication-status	Published online
pubs.volume	9
utslib.citation.issue	7

Abstract:

In recent years, the practical application of protein-based nanoparticles (PNPs) has expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis. PNPs possess unique features that make them attractive as potential platforms for a variety of nanobiotechnological applications. They self-assemble from multiple protein subunits into hollow monodisperse structures; they are highly stable, biocompatible, and biodegradable; and their external components and encapsulation properties can be readily manipulated by chemical or genetic strategies. Moreover, their complex and perfect symmetry have motivated researchers to mimic their properties in order to create de novo protein assemblies. This review focuses on recent advances in the bioengineering and bioconjugation of PNPs and the implementation of synthetic biology concepts to exploit and enhance PNP's intrinsic properties and to impart them with novel functionalities.

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http://hdl.handle.net/10453/155564