Maternal overnutrition impacts offspring adiposity and brain appetite markers-modulation by postweaning diet

Rajia, S; Chen, H; Morris, MJ

Maternal overnutrition impacts offspring adiposity and brain appetite markers-modulation by postweaning diet

Rajia, S Chen, H

Morris, MJ

Permalink

Publication Type:: Journal Article
Citation:: Journal of Neuroendocrinology, 2010, 22 (8), pp. 905 - 914
Issue Date:: 2010-08-01

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download full textAdobe PDF (300.38 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Rajia, S	en_US
dc.contributor.author	Chen, H https://orcid.org/0000-0001-6883-3752	en_US
dc.contributor.author	Morris, MJ	en_US
dc.date.issued	2010-08-01	en_US
dc.identifier.citation	Journal of Neuroendocrinology, 2010, 22 (8), pp. 905 - 914	en_US
dc.identifier.issn	0953-8194	en_US
dc.identifier.uri	http://hdl.handle.net/10453/15560
dc.description.abstract	Maternal obesity has long-term consequences for the development of hypothalamic neurones involved in energy homeostasis and the metabolic profile in offspring. In the present study, we compared the effects of maternal obesity induced by longstanding high-fat diet (HFD) with milder postnatal overfeeding during suckling induced by litter size reduction. Female Sprague-Dawley rats consumed chow (C) or HFD. On postnatal day 1, litters from chow dams were adjusted to three per dam (small litter, CS) versus 12 control (normal litter, CN). Litters from HFD dams were adjusted to 12 per dam and fed HFD after weaning to induce obesity (HN). Thus, two degrees of maternal overnutrition were produced (CS and HN). To test whether postweaning diet can amplify the effects of maternal obesity, male offspring weaned onto chow or HFD were followed to 21 weeks. Maternal postnatal overnutrition (CS) and HFD-induced maternal obesity (HN) increased body weight and fat mass in offspring compared to those from control dams (CN). Significant glucose intolerance was induced by both degrees of maternal overnutrition, but only in offspring consuming HFD. HFD-induced maternal obesity (HN) was linked to increased offspring leptin, insulin, lipids, insulin resistance and hyperphagia, and was exaggerated by postweaning HFD. No effect of maternal postnatal overnutrition (CS) was seen on these parameters. Hypothalamic signal transducer and activator of transcription-3 and suppressor of cytokine signalling-3 mRNA were significantly elevated by maternal HFD (HN) in the HFD-fed offspring. The data obtained suggest that even mild maternal overnutrition (CS) led to increased adiposity, glucose intolerance and altered brain appetite regulators in offspring. A greater impact of HFD-induced maternal obesity was evident. Marked additive effects were observed when animals consumed a HFD postweaning. © 2010 The Authors. Journal Compilation © 2010 Blackwell Publishing Ltd.	en_US
dc.relation.ispartof	Journal of Neuroendocrinology	en_US
dc.relation.isbasedon	10.1111/j.1365-2826.2010.02005.x	en_US
dc.subject.classification	Endocrinology & Metabolism	en_US
dc.subject.mesh	Brain	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Animals, Newborn	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Rats	en_US
dc.subject.mesh	Rats, Sprague-Dawley	en_US
dc.subject.mesh	Overnutrition	en_US
dc.subject.mesh	Body Weight	en_US
dc.subject.mesh	Glucose	en_US
dc.subject.mesh	RNA, Messenger	en_US
dc.subject.mesh	Biological Markers	en_US
dc.subject.mesh	Glucose Tolerance Test	en_US
dc.subject.mesh	Diet	en_US
dc.subject.mesh	Appetite	en_US
dc.subject.mesh	Weaning	en_US
dc.subject.mesh	Eating	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Child	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Adiposity	en_US
dc.subject.mesh	Maternal Nutritional Physiological Phenomena	en_US
dc.subject.mesh	Biomarkers	en_US
dc.title	Maternal overnutrition impacts offspring adiposity and brain appetite markers-modulation by postweaning diet	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	22	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1109 Neurosciences	en_US
dc.location.activity	St. Maarten, The Netherlands Antilles
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	22	en_US

Abstract:

Maternal obesity has long-term consequences for the development of hypothalamic neurones involved in energy homeostasis and the metabolic profile in offspring. In the present study, we compared the effects of maternal obesity induced by longstanding high-fat diet (HFD) with milder postnatal overfeeding during suckling induced by litter size reduction. Female Sprague-Dawley rats consumed chow (C) or HFD. On postnatal day 1, litters from chow dams were adjusted to three per dam (small litter, CS) versus 12 control (normal litter, CN). Litters from HFD dams were adjusted to 12 per dam and fed HFD after weaning to induce obesity (HN). Thus, two degrees of maternal overnutrition were produced (CS and HN). To test whether postweaning diet can amplify the effects of maternal obesity, male offspring weaned onto chow or HFD were followed to 21 weeks. Maternal postnatal overnutrition (CS) and HFD-induced maternal obesity (HN) increased body weight and fat mass in offspring compared to those from control dams (CN). Significant glucose intolerance was induced by both degrees of maternal overnutrition, but only in offspring consuming HFD. HFD-induced maternal obesity (HN) was linked to increased offspring leptin, insulin, lipids, insulin resistance and hyperphagia, and was exaggerated by postweaning HFD. No effect of maternal postnatal overnutrition (CS) was seen on these parameters. Hypothalamic signal transducer and activator of transcription-3 and suppressor of cytokine signalling-3 mRNA were significantly elevated by maternal HFD (HN) in the HFD-fed offspring. The data obtained suggest that even mild maternal overnutrition (CS) led to increased adiposity, glucose intolerance and altered brain appetite regulators in offspring. A greater impact of HFD-induced maternal obesity was evident. Marked additive effects were observed when animals consumed a HFD postweaning. © 2010 The Authors. Journal Compilation © 2010 Blackwell Publishing Ltd.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/15560