The synthesis of hydroxyapatite from artificially grown Red Sea hydrozoan coral for antimicrobacterial drug delivery system applications

Karacan, I; Cox, N; Dowd, A; Vago, R; Milthorpe, B; Cazalbou, S; Ben-Nissan, B

The synthesis of hydroxyapatite from artificially grown Red Sea hydrozoan coral for antimicrobacterial drug delivery system applications

Karacan, I Cox, N Dowd, A

Vago, R Milthorpe, B

Cazalbou, S Ben-Nissan, B

Permalink

Publisher:: SPRINGER
Publication Type:: Journal Article
Citation:: Journal of the Australian Ceramic Society, 2021, 57, (2), pp. 399-407
Issue Date:: 2021-04-01

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

The embargo period expires on 30 Apr 2022

Adobe PDF

Download Accepted versionAdobe PDF (1.35 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Karacan, I
dc.contributor.author	Cox, N
dc.contributor.author	Dowd, A https://orcid.org/0000-0002-0500-3599
dc.contributor.author	Vago, R
dc.contributor.author	Milthorpe, B https://orcid.org/0000-0002-0867-9586
dc.contributor.author	Cazalbou, S
dc.contributor.author	Ben-Nissan, B
dc.date.accessioned	2022-03-27T22:45:45Z
dc.date.available	2022-03-27T22:45:45Z
dc.date.issued	2021-04-01
dc.identifier.citation	Journal of the Australian Ceramic Society, 2021, 57, (2), pp. 399-407
dc.identifier.issn	2510-1560
dc.identifier.issn	2510-1579
dc.identifier.uri	http://hdl.handle.net/10453/155614
dc.description.abstract	The hydrozoan Millepora dichotoma (MD) is a typical Red Sea species containing a porous skeleton in the form of aragonite crystalline calcium carbonate. Due to environmental considerations, the artificial production of coralline species under controlled conditions is pertinent and underway. Artificially grown MD was used as a raw material for the production of calcium phosphate, mainly hydroxyapatite bioceramics, to be used in the drug delivery systems as a drug carrier or in the tissue engineering such as bone graft. DTA-TGA, XRD, FT-IR, Raman, and SEM analysis were carried out to analyze both unconverted and converted artificial corals. Hydrothermally converted coral fine powders were loaded with gentamicin (Gm) antibiotic, and the drug-loaded particles were analyzed by SEM. Unconverted coral was mainly aragonite, while hydrothermally treated coral was completely converted to hydroxyapatite. Hydrothermally treated coral was showing agglomerated nodules up to 1-μm size consisting of nanocrystalline hydroxyapatite platelets in the size range of less than 100 nm. The general macropore size of the coral was found to be appropriate for osteoid growth, which is 100 to 600 μm range. These artificially grown corals can be easily produced and used for bone growth and repair and other biomedical applications.
dc.language	English
dc.publisher	SPRINGER
dc.relation.ispartof	Journal of the Australian Ceramic Society
dc.relation.isbasedon	10.1007/s41779-020-00554-1
dc.rights	The final publication is available at Springer via http://dx.doi.org/ 10.1007/s41779-020-00554-1
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.title	The synthesis of hydroxyapatite from artificially grown Red Sea hydrozoan coral for antimicrobacterial drug delivery system applications
dc.type	Journal Article
utslib.citation.volume	57
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2022-04-30T00:00:00+1000Z
dc.date.updated	2022-03-27T22:45:42Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	57
utslib.citation.issue	2

Abstract:

The hydrozoan Millepora dichotoma (MD) is a typical Red Sea species containing a porous skeleton in the form of aragonite crystalline calcium carbonate. Due to environmental considerations, the artificial production of coralline species under controlled conditions is pertinent and underway. Artificially grown MD was used as a raw material for the production of calcium phosphate, mainly hydroxyapatite bioceramics, to be used in the drug delivery systems as a drug carrier or in the tissue engineering such as bone graft. DTA-TGA, XRD, FT-IR, Raman, and SEM analysis were carried out to analyze both unconverted and converted artificial corals. Hydrothermally converted coral fine powders were loaded with gentamicin (Gm) antibiotic, and the drug-loaded particles were analyzed by SEM. Unconverted coral was mainly aragonite, while hydrothermally treated coral was completely converted to hydroxyapatite. Hydrothermally treated coral was showing agglomerated nodules up to 1-μm size consisting of nanocrystalline hydroxyapatite platelets in the size range of less than 100 nm. The general macropore size of the coral was found to be appropriate for osteoid growth, which is 100 to 600 μm range. These artificially grown corals can be easily produced and used for bone growth and repair and other biomedical applications.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/155614