Incorporation of the pentafluorosulfanyl group through common synthetic transformations
- Publisher:
- SPRINGER WIEN
- Publication Type:
- Journal Article
- Citation:
- Monatshefte fur Chemie, 2021, 152, (4), pp. 449-459
- Issue Date:
- 2021-04-01
Closed Access
Filename | Description | Size | |||
---|---|---|---|---|---|
Incorporation of the pentafluorosulfanyl group through common synthetic transformations.pdf | Published version | 12.98 MB |
Copyright Clearance Process
- Recently Added
- In Progress
- Closed Access
This item is closed access and not available.
The incorporation of –SF5 group onto model amino acids has been achieved using commercially available synthons substituted with this group. This work investigates the influence of the –SF5 group on a variety of common synthetic transformations utilized in fields of bioconjugation and drug development, namely, amide coupling, reductive amination, diazo-coupling, and CuAAC “click” reactions. The influence of the novel substituent on the success of these common transformations is presented, and alternative approaches for those which proved unsatisfactory are proposed herein. Graphic abstract: [Figure not available: see fulltext.]
Please use this identifier to cite or link to this item: