Male Rat Offspring Are More Impacted by Maternal Obesity Induced by Cafeteria Diet than Females-Additive Effect of Postweaning Diet.
- Publisher:
- MDPI
- Publication Type:
- Journal Article
- Citation:
- Int J Mol Sci, 2022, 23, (3)
- Issue Date:
- 2022-01-27
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Tajaddini, A | |
dc.contributor.author | Kendig, MD | |
dc.contributor.author | Prates, KV | |
dc.contributor.author | Westbrook, RF | |
dc.contributor.author | Morris, MJ | |
dc.date.accessioned | 2022-03-29T21:45:42Z | |
dc.date.available | 2022-01-26 | |
dc.date.available | 2022-03-29T21:45:42Z | |
dc.date.issued | 2022-01-27 | |
dc.identifier.citation | Int J Mol Sci, 2022, 23, (3) | |
dc.identifier.issn | 1422-0067 | |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/10453/155677 | |
dc.description.abstract | Maternal obesity increases the risk of health complications in offspring, but whether these effects are exacerbated by offspring exposure to unhealthy diets warrants further investigation. Female Sprague-Dawley rats were fed either standard chow (n = 15) or 'cafeteria' (Caf, n = 21) diets across pre-pregnancy, gestation, and lactation. Male and female offspring were weaned onto chow or Caf diet (2-3/sex/litter), forming four groups; behavioural and metabolic parameters were assessed. At weaning, offspring from Caf dams were smaller and lighter, but had more retroperitoneal (RP) fat, with a larger effect in males. Maternal Caf diet significantly increased relative expression of ACACA and Fasn in male and female weanling liver, but not CPT-1, SREBP and PGC1; PPARα was increased in males from Caf dams. Maternal obesity enhanced the impact of postweaning Caf exposure on adult body weight, RP fat, liver mass, and plasma leptin in males but not females. Offspring from Caf dams appeared to exhibit reduced anxiety-like behaviour on the elevated plus maze. Hepatic CPT-1 expression was reduced only in adult males from Caf fed dams. Post weaning Caf diet consumption did not alter liver gene expression in the adult offspring. Maternal obesity exacerbated the obesogenic phenotype produced by postweaning Caf diet in male, but not female offspring. Thus, the impact of maternal obesity on adiposity and liver gene expression appeared more marked in males. Our data underline the sex-specific detrimental effects of maternal obesity on offspring. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | MDPI | |
dc.relation.ispartof | Int J Mol Sci | |
dc.relation.isbasedon | 10.3390/ijms23031442 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 0399 Other Chemical Sciences, 0604 Genetics, 0699 Other Biological Sciences | |
dc.subject.classification | Chemical Physics | |
dc.subject.mesh | Acetyl-CoA Carboxylase | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Body Weight | |
dc.subject.mesh | Diet, High-Fat | |
dc.subject.mesh | Fatty Acid Synthase, Type I | |
dc.subject.mesh | Female | |
dc.subject.mesh | Gene Expression Regulation | |
dc.subject.mesh | Glucose | |
dc.subject.mesh | Leptin | |
dc.subject.mesh | Male | |
dc.subject.mesh | Maternal Nutritional Physiological Phenomena | |
dc.subject.mesh | Obesity, Maternal | |
dc.subject.mesh | Pregnancy | |
dc.subject.mesh | Prenatal Exposure Delayed Effects | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Rats, Sprague-Dawley | |
dc.subject.mesh | Weaning | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Rats, Sprague-Dawley | |
dc.subject.mesh | Prenatal Exposure Delayed Effects | |
dc.subject.mesh | Body Weight | |
dc.subject.mesh | Leptin | |
dc.subject.mesh | Acetyl-CoA Carboxylase | |
dc.subject.mesh | Glucose | |
dc.subject.mesh | Gene Expression Regulation | |
dc.subject.mesh | Weaning | |
dc.subject.mesh | Pregnancy | |
dc.subject.mesh | Female | |
dc.subject.mesh | Male | |
dc.subject.mesh | Maternal Nutritional Physiological Phenomena | |
dc.subject.mesh | Diet, High-Fat | |
dc.subject.mesh | Fatty Acid Synthase, Type I | |
dc.subject.mesh | Obesity, Maternal | |
dc.title | Male Rat Offspring Are More Impacted by Maternal Obesity Induced by Cafeteria Diet than Females-Additive Effect of Postweaning Diet. | |
dc.type | Journal Article | |
utslib.citation.volume | 23 | |
utslib.location.activity | Switzerland | |
utslib.for | 0399 Other Chemical Sciences | |
utslib.for | 0604 Genetics | |
utslib.for | 0699 Other Biological Sciences | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2022-03-29T21:45:35Z | |
pubs.issue | 3 | |
pubs.publication-status | Published online | |
pubs.volume | 23 | |
utslib.citation.issue | 3 |
Abstract:
Maternal obesity increases the risk of health complications in offspring, but whether these effects are exacerbated by offspring exposure to unhealthy diets warrants further investigation. Female Sprague-Dawley rats were fed either standard chow (n = 15) or 'cafeteria' (Caf, n = 21) diets across pre-pregnancy, gestation, and lactation. Male and female offspring were weaned onto chow or Caf diet (2-3/sex/litter), forming four groups; behavioural and metabolic parameters were assessed. At weaning, offspring from Caf dams were smaller and lighter, but had more retroperitoneal (RP) fat, with a larger effect in males. Maternal Caf diet significantly increased relative expression of ACACA and Fasn in male and female weanling liver, but not CPT-1, SREBP and PGC1; PPARα was increased in males from Caf dams. Maternal obesity enhanced the impact of postweaning Caf exposure on adult body weight, RP fat, liver mass, and plasma leptin in males but not females. Offspring from Caf dams appeared to exhibit reduced anxiety-like behaviour on the elevated plus maze. Hepatic CPT-1 expression was reduced only in adult males from Caf fed dams. Post weaning Caf diet consumption did not alter liver gene expression in the adult offspring. Maternal obesity exacerbated the obesogenic phenotype produced by postweaning Caf diet in male, but not female offspring. Thus, the impact of maternal obesity on adiposity and liver gene expression appeared more marked in males. Our data underline the sex-specific detrimental effects of maternal obesity on offspring.
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