A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58.
Reid, CJ
Cummins, ML
Börjesson, S
Brouwer, MSM
Hasman, H
Hammerum, AM
Roer, L
Hess, S
Berendonk, T
Nešporová, K
Haenni, M
Madec, J-Y
Bethe, A
Michael, GB
Schink, A-K
Schwarz, S
Dolejska, M
Djordjevic, SP
- Publisher:
- NATURE PORTFOLIO
- Publication Type:
- Journal Article
- Citation:
- Nat Commun, 2022, 13, (1), pp. 683
- Issue Date:
- 2022-02-03
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Reid, CJ | |
dc.contributor.author | Cummins, ML | |
dc.contributor.author | Börjesson, S | |
dc.contributor.author | Brouwer, MSM | |
dc.contributor.author | Hasman, H | |
dc.contributor.author | Hammerum, AM | |
dc.contributor.author | Roer, L | |
dc.contributor.author | Hess, S | |
dc.contributor.author | Berendonk, T | |
dc.contributor.author | Nešporová, K | |
dc.contributor.author | Haenni, M | |
dc.contributor.author | Madec, J-Y | |
dc.contributor.author | Bethe, A | |
dc.contributor.author | Michael, GB | |
dc.contributor.author | Schink, A-K | |
dc.contributor.author | Schwarz, S | |
dc.contributor.author | Dolejska, M | |
dc.contributor.author | Djordjevic, SP | |
dc.date.accessioned | 2022-04-01T03:27:24Z | |
dc.date.available | 2022-01-11 | |
dc.date.available | 2022-04-01T03:27:24Z | |
dc.date.issued | 2022-02-03 | |
dc.identifier.citation | Nat Commun, 2022, 13, (1), pp. 683 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/10453/155861 | |
dc.description.abstract | Escherichia coli ST58 has recently emerged as a globally disseminated uropathogen that often progresses to sepsis. Unlike most pandemic extra-intestinal pathogenic E. coli (ExPEC), which belong to pathogenic phylogroup B2, ST58 belongs to the environmental/commensal phylogroup B1. Here, we present a pan-genomic analysis of a global collection of 752 ST58 isolates from diverse sources. We identify a large ST58 sub-lineage characterized by near ubiquitous carriage of ColV plasmids, which carry genes encoding virulence factors, and by a distinct accessory genome including genes typical of the Yersiniabactin High Pathogenicity Island. This sub-lineage includes three-quarters of all ExPEC sequences in our study and has a broad host range, although poultry and porcine sources predominate. By contrast, strains isolated from cattle often lack ColV plasmids. Our data indicate that ColV plasmid acquisition contributed to the divergence of the major ST58 sub-lineage, and different sub-lineages inhabit poultry, swine and cattle. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.relation | http://purl.org/au-research/grants/arc/LP150100912 | |
dc.relation.ispartof | Nat Commun | |
dc.relation.isbasedon | 10.1038/s41467-022-28342-4 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Cattle | |
dc.subject.mesh | Drug Resistance, Microbial | |
dc.subject.mesh | Escherichia coli | |
dc.subject.mesh | Escherichia coli Infections | |
dc.subject.mesh | Evolution, Molecular | |
dc.subject.mesh | Genome, Bacterial | |
dc.subject.mesh | Genomic Islands | |
dc.subject.mesh | Genomics | |
dc.subject.mesh | Host Specificity | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Phylogeny | |
dc.subject.mesh | Plasmids | |
dc.subject.mesh | Poultry | |
dc.subject.mesh | Species Specificity | |
dc.subject.mesh | Swine | |
dc.subject.mesh | Virulence | |
dc.subject.mesh | Virulence Factors | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Poultry | |
dc.subject.mesh | Cattle | |
dc.subject.mesh | Swine | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Escherichia coli | |
dc.subject.mesh | Escherichia coli Infections | |
dc.subject.mesh | Virulence Factors | |
dc.subject.mesh | Genomics | |
dc.subject.mesh | Evolution, Molecular | |
dc.subject.mesh | Phylogeny | |
dc.subject.mesh | Drug Resistance, Microbial | |
dc.subject.mesh | Virulence | |
dc.subject.mesh | Species Specificity | |
dc.subject.mesh | Genomic Islands | |
dc.subject.mesh | Genome, Bacterial | |
dc.subject.mesh | Plasmids | |
dc.subject.mesh | Host Specificity | |
dc.title | A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58. | |
dc.type | Journal Article | |
utslib.citation.volume | 13 | |
utslib.location.activity | England | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2022-04-01T03:27:18Z | |
pubs.issue | 1 | |
pubs.publication-status | Published online | |
pubs.volume | 13 | |
utslib.citation.issue | 1 |
Abstract:
Escherichia coli ST58 has recently emerged as a globally disseminated uropathogen that often progresses to sepsis. Unlike most pandemic extra-intestinal pathogenic E. coli (ExPEC), which belong to pathogenic phylogroup B2, ST58 belongs to the environmental/commensal phylogroup B1. Here, we present a pan-genomic analysis of a global collection of 752 ST58 isolates from diverse sources. We identify a large ST58 sub-lineage characterized by near ubiquitous carriage of ColV plasmids, which carry genes encoding virulence factors, and by a distinct accessory genome including genes typical of the Yersiniabactin High Pathogenicity Island. This sub-lineage includes three-quarters of all ExPEC sequences in our study and has a broad host range, although poultry and porcine sources predominate. By contrast, strains isolated from cattle often lack ColV plasmids. Our data indicate that ColV plasmid acquisition contributed to the divergence of the major ST58 sub-lineage, and different sub-lineages inhabit poultry, swine and cattle.
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