Inhibition Of Highly Pathogenic Avian H5N1 Influenza Virus Propagation By Rna Oligonucleotides Targeting The Pb2 Gene In Combination With Celecoxib

Publisher:
Wiley-Blackwell
Publication Type:
Journal Article
Citation:
Journal Of Gene Medicine, 2011, 13 (4), pp. 243 - 249
Issue Date:
2011-01
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Background Highly pathogenic avian influenza virus H5N1 can cause acute respiratory infections with an uncontrolled virus-induced cytokine storm in both poultry and humans. In view of the high mortality of H5N1 influenza virus infection, the development of novel broad-spectrum prophylactic and therapeutic agents against infection is urgently needed. In the present study, we attempted to explore whether the combinational use of a viral genetargeted agent and immunomodulator is feasible as a new strategy against the H5N1 infection.
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