Sex-dependent association between selenium status and cognitive performance in older adults.

R Cardoso, B; Hare, DJ; Macpherson, H

Sex-dependent association between selenium status and cognitive performance in older adults.

R Cardoso, B Hare, DJ Macpherson, H

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Publisher:: Springer Science and Business Media LLC
Publication Type:: Journal Article
Citation:: Eur J Nutr, 2021, 60, (2), pp. 1153-1159
Issue Date:: 2021-03

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Field	Value	Language
dc.contributor.author	R Cardoso, B
dc.contributor.author	Hare, DJ
dc.contributor.author	Macpherson, H
dc.date.accessioned	2022-06-06T07:00:30Z
dc.date.available	2020-09-03
dc.date.available	2022-06-06T07:00:30Z
dc.date.issued	2021-03
dc.identifier.citation	Eur J Nutr, 2021, 60, (2), pp. 1153-1159
dc.identifier.issn	1436-6207
dc.identifier.issn	1436-6215
dc.identifier.uri	http://hdl.handle.net/10453/157981
dc.description.abstract	PURPOSE: Selenium (Se) is an essential nutrient required for maintaining brain health across lifespan, and adequate nutritional Se status has been positively associated with sustained cognitive performance in older adults. However, critical physiological sex differences in Se metabolism have not been specifically assessed in human studies. Therefore, we aimed to investigate sex differences in the association between Se concentration in whole blood and cognitive performance in US older adults. METHODS: This cross-sectional study included 2016 participants (984 male and 1032 female) ≥ 60 years from the 2011 to 2014 National Health and Nutrition Survey (NHANES). All participants were assessed for whole blood Se concentration and completed the following battery of cognitive tests: Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word Learning Test, Animal Fluency test, and Digit Symbol Substitution Test (DSST). RESULTS: In this cohort, all participants presented with adequate Se status (mean 196.7 μg/L; 95% CI 193.5, 200.0), and cohort-wide scores were equivalent to a cognitively healthy population. A sex effect on CERAD recall (P = 0.005) and animal fluency (P = 0.018) was observed in models adjusted for age, diabetes, history of cardiovascular disease, physical activity and body mass index. Se concentration was positively associated with CERAD recall (β: 0.015, 95% CI 0.007, 0.022) and animal fluency (β: 0.017, 95% CI 0.003, 0.030) performance in males only, while no associations were observed for females. CONCLUSION: This study provides the first evidence for sex differences in the association between Se status and cognitive performance in older adults.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartof	Eur J Nutr
dc.relation.isbasedon	10.1007/s00394-020-02384-0
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1111 Nutrition and Dietetics
dc.subject.classification	Nutrition & Dietetics
dc.subject.mesh	Aged
dc.subject.mesh	Animals
dc.subject.mesh	Cognition
dc.subject.mesh	Cognitive Dysfunction
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Male
dc.subject.mesh	Nutrition Surveys
dc.subject.mesh	Nutritional Status
dc.subject.mesh	Selenium
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Selenium
dc.subject.mesh	Nutrition Surveys
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Cognition
dc.subject.mesh	Nutritional Status
dc.subject.mesh	Aged
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Cognitive Dysfunction
dc.title	Sex-dependent association between selenium status and cognitive performance in older adults.
dc.type	Journal Article
utslib.citation.volume	60
utslib.location.activity	Germany
utslib.for	1111 Nutrition and Dietetics
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2022-06-06T07:00:29Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	60
utslib.citation.issue	2

Abstract:

PURPOSE: Selenium (Se) is an essential nutrient required for maintaining brain health across lifespan, and adequate nutritional Se status has been positively associated with sustained cognitive performance in older adults. However, critical physiological sex differences in Se metabolism have not been specifically assessed in human studies. Therefore, we aimed to investigate sex differences in the association between Se concentration in whole blood and cognitive performance in US older adults. METHODS: This cross-sectional study included 2016 participants (984 male and 1032 female) ≥ 60 years from the 2011 to 2014 National Health and Nutrition Survey (NHANES). All participants were assessed for whole blood Se concentration and completed the following battery of cognitive tests: Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word Learning Test, Animal Fluency test, and Digit Symbol Substitution Test (DSST). RESULTS: In this cohort, all participants presented with adequate Se status (mean 196.7 μg/L; 95% CI 193.5, 200.0), and cohort-wide scores were equivalent to a cognitively healthy population. A sex effect on CERAD recall (P = 0.005) and animal fluency (P = 0.018) was observed in models adjusted for age, diabetes, history of cardiovascular disease, physical activity and body mass index. Se concentration was positively associated with CERAD recall (β: 0.015, 95% CI 0.007, 0.022) and animal fluency (β: 0.017, 95% CI 0.003, 0.030) performance in males only, while no associations were observed for females. CONCLUSION: This study provides the first evidence for sex differences in the association between Se status and cognitive performance in older adults.

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http://hdl.handle.net/10453/157981