Increasing Antibiotic Susceptibility: The Use of Cationic Gold Nanoparticles in Gram-Negative Bacterial Membrane Models.

Andersson, J; Fuller, M; Ashenden, A; Holt, SA; Köper, I

Increasing Antibiotic Susceptibility: The Use of Cationic Gold Nanoparticles in Gram-Negative Bacterial Membrane Models.

Andersson, J Fuller, M Ashenden, A Holt, SA Köper, I

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Publisher:: AMER CHEMICAL SOC
Publication Type:: Journal Article
Citation:: Langmuir, 2021, 37, (32), pp. 9735-9743
Issue Date:: 2021-08-17

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Field	Value	Language
dc.contributor.author	Andersson, J
dc.contributor.author	Fuller, M
dc.contributor.author	Ashenden, A
dc.contributor.author	Holt, SA
dc.contributor.author	Köper, I
dc.date.accessioned	2022-06-18T00:57:04Z
dc.date.available	2022-06-18T00:57:04Z
dc.date.issued	2021-08-17
dc.identifier.citation	Langmuir, 2021, 37, (32), pp. 9735-9743
dc.identifier.issn	0743-7463
dc.identifier.issn	1520-5827
dc.identifier.uri	http://hdl.handle.net/10453/158235
dc.description.abstract	Antibiotic resistance will be one of the most prominent challenges to health-care systems in the coming decades, with the OECD predicting that up to 2.4 million deaths will be caused between 2015 and 2050 by drug-resistant bacterial infections in first-world countries alone, with infections costing health-care systems billions of dollars each year. Developing new methods to increase bacterial susceptibility toward drugs is an important step in treating resistant infections. Here, the synergistic effects of gold nanoparticles and the antibiotic drug colistin sulfate have been examined. A tethered lipid bilayer membrane was used to mimic a Gram-negative bacterial cell membrane. Exposing the membrane to gold nanoparticles prior to adding the antibiotic significantly increased the effect of the antibiotic on the membrane. Cationic gold nanoparticles could thus be used to enhance bacterial susceptibility to antibiotics, leading to a more potent treatment.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	AMER CHEMICAL SOC
dc.relation.ispartof	Langmuir
dc.relation.isbasedon	10.1021/acs.langmuir.1c01150
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Chemical Physics
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Colistin
dc.subject.mesh	Gold
dc.subject.mesh	Gram-Negative Bacteria
dc.subject.mesh	Humans
dc.subject.mesh	Metal Nanoparticles
dc.subject.mesh	Microbial Sensitivity Tests
dc.subject.mesh	Humans
dc.subject.mesh	Gram-Negative Bacteria
dc.subject.mesh	Gold
dc.subject.mesh	Colistin
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Microbial Sensitivity Tests
dc.subject.mesh	Metal Nanoparticles
dc.title	Increasing Antibiotic Susceptibility: The Use of Cationic Gold Nanoparticles in Gram-Negative Bacterial Membrane Models.
dc.type	Journal Article
utslib.citation.volume	37
utslib.location.activity	United States
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2022-06-18T00:57:02Z
pubs.issue	32
pubs.publication-status	Published
pubs.volume	37
utslib.citation.issue	32

Abstract:

Antibiotic resistance will be one of the most prominent challenges to health-care systems in the coming decades, with the OECD predicting that up to 2.4 million deaths will be caused between 2015 and 2050 by drug-resistant bacterial infections in first-world countries alone, with infections costing health-care systems billions of dollars each year. Developing new methods to increase bacterial susceptibility toward drugs is an important step in treating resistant infections. Here, the synergistic effects of gold nanoparticles and the antibiotic drug colistin sulfate have been examined. A tethered lipid bilayer membrane was used to mimic a Gram-negative bacterial cell membrane. Exposing the membrane to gold nanoparticles prior to adding the antibiotic significantly increased the effect of the antibiotic on the membrane. Cationic gold nanoparticles could thus be used to enhance bacterial susceptibility to antibiotics, leading to a more potent treatment.

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http://hdl.handle.net/10453/158235