Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy.

Li, D; Zhang, Y; Wen, S; Song, Y; Tang, Y; Zhu, X; Shen, M; Mignani, S; Majoral, J-P; Zhao, Q; Shi, X

Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy.

Li, D Zhang, Y Wen, S

Song, Y Tang, Y Zhu, X Shen, M Mignani, S Majoral, J-P Zhao, Q Shi, X

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Publisher:: ROYAL SOC CHEMISTRY
Publication Type:: Journal Article
Citation:: J Mater Chem B, 2016, 4, (23), pp. 4216-4226
Issue Date:: 2016-06-21

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Field	Value	Language
dc.contributor.author	Li, D
dc.contributor.author	Zhang, Y
dc.contributor.author	Wen, S https://orcid.org/0000-0002-4670-4658
dc.contributor.author	Song, Y
dc.contributor.author	Tang, Y
dc.contributor.author	Zhu, X
dc.contributor.author	Shen, M
dc.contributor.author	Mignani, S
dc.contributor.author	Majoral, J-P
dc.contributor.author	Zhao, Q
dc.contributor.author	Shi, X
dc.date.accessioned	2022-07-23T21:09:01Z
dc.date.available	2022-07-23T21:09:01Z
dc.date.issued	2016-06-21
dc.identifier.citation	J Mater Chem B, 2016, 4, (23), pp. 4216-4226
dc.identifier.issn	2050-750X
dc.identifier.issn	2050-7518
dc.identifier.uri	http://hdl.handle.net/10453/159137
dc.description.abstract	The advancement of biocompatible nanoplatforms with dual functionalities of diagnosis and therapeutics has been strongly demanded in biomedicine in recent years. In this work, we report the synthesis and characterization of polydopamine (pD)-coated gold nanostars (Au NSs) for computed tomography (CT) imaging and enhanced photothermal therapy (PTT) of tumors. Au NSs were firstly formed via a seed-mediated growth method and then stabilized with thiolated polyethyleneimine (PEI-SH), followed by deposition of pD on their surface. The formed pD-coated Au NSs (Au-PEI@pD NSs) were well characterized. We show that the Au-PEI@pD NSs are able to convert the absorbed near-infrared laser light into heat, and have strong X-ray attenuation properties. Due to the co-existence of Au NSs and pD, the light to heat conversion efficiency of the NSs can be significantly enhanced. These very interesting properties allow them to be used as a powerful theranostic nanoplatform for efficient CT imaging and enhanced phtotothermal therapy of cancer cells in vitro and the xenografted tumor model in vivo. Due to their easy functionalization nature enabled by the coated pD shell, the developed pD-coated Au NSs may be used as a versatile nanoplatform for targeted CT imaging and PTT of different types of cancers.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ROYAL SOC CHEMISTRY
dc.relation.ispartof	J Mater Chem B
dc.relation.isbasedon	10.1039/c6tb00773b
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0303 Macromolecular and Materials Chemistry, 0903 Biomedical Engineering
dc.title	Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy.
dc.type	Journal Article
utslib.citation.volume	4
utslib.location.activity	England
utslib.for	0303 Macromolecular and Materials Chemistry
utslib.for	0903 Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2022-07-23T21:08:58Z
pubs.issue	23
pubs.publication-status	Published
pubs.volume	4
utslib.citation.issue	23

Abstract:

The advancement of biocompatible nanoplatforms with dual functionalities of diagnosis and therapeutics has been strongly demanded in biomedicine in recent years. In this work, we report the synthesis and characterization of polydopamine (pD)-coated gold nanostars (Au NSs) for computed tomography (CT) imaging and enhanced photothermal therapy (PTT) of tumors. Au NSs were firstly formed via a seed-mediated growth method and then stabilized with thiolated polyethyleneimine (PEI-SH), followed by deposition of pD on their surface. The formed pD-coated Au NSs (Au-PEI@pD NSs) were well characterized. We show that the Au-PEI@pD NSs are able to convert the absorbed near-infrared laser light into heat, and have strong X-ray attenuation properties. Due to the co-existence of Au NSs and pD, the light to heat conversion efficiency of the NSs can be significantly enhanced. These very interesting properties allow them to be used as a powerful theranostic nanoplatform for efficient CT imaging and enhanced phtotothermal therapy of cancer cells in vitro and the xenografted tumor model in vivo. Due to their easy functionalization nature enabled by the coated pD shell, the developed pD-coated Au NSs may be used as a versatile nanoplatform for targeted CT imaging and PTT of different types of cancers.

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http://hdl.handle.net/10453/159137