Targeting the IL-33/IL-13 Axis for Respiratory Viral Infections.
- Publisher:
- Elsevier BV
- Publication Type:
- Journal Article
- Citation:
- Trends Pharmacol Sci, 2016, 37, (4), pp. 252-261
- Issue Date:
- 2016-04
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1-s2.0-S0165614716000055-main.pdf | Published version | 1.54 MB |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author |
Donovan, C https://orcid.org/0000-0003-4558-329X |
|
dc.contributor.author | Bourke, JE | |
dc.contributor.author | Vlahos, R | |
dc.date.accessioned | 2022-08-11T06:31:37Z | |
dc.date.available | 2016-01-07 | |
dc.date.available | 2022-08-11T06:31:37Z | |
dc.date.issued | 2016-04 | |
dc.identifier.citation | Trends Pharmacol Sci, 2016, 37, (4), pp. 252-261 | |
dc.identifier.issn | 0165-6147 | |
dc.identifier.issn | 1873-3735 | |
dc.identifier.uri | http://hdl.handle.net/10453/159949 | |
dc.description.abstract | Lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are highly prevalent worldwide. One of the major factors that limits the efficacy of current medication in these patients are viral infections, leading to exacerbations of symptoms and decreased quality of life. Current pharmacological strategies targeting virus-induced lung disease are problematic due to antiviral resistance and the requirement for strain-specific vaccination. Thus, new therapeutic strategies are urgently required. In this Opinion article, we provide state-of-the-art evidence from humans and preclinical animal models implicating the interleukin (IL)-33/IL-13 axis in virus-induced lung disease. Thus, targeting the IL-33/IL-13 axis may be a feasible way to overcome the limitations of current therapy used to treat virus-induced exacerbations of lung disease. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Elsevier BV | |
dc.relation.ispartof | Trends Pharmacol Sci | |
dc.relation.isbasedon | 10.1016/j.tips.2016.01.004 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 06 Biological Sciences, 11 Medical and Health Sciences | |
dc.subject.classification | Pharmacology & Pharmacy | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Antiviral Agents | |
dc.subject.mesh | Asthma | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Immunity, Innate | |
dc.subject.mesh | Interleukin-13 | |
dc.subject.mesh | Interleukin-33 | |
dc.subject.mesh | Molecular Targeted Therapy | |
dc.subject.mesh | Pulmonary Disease, Chronic Obstructive | |
dc.subject.mesh | Respiratory Hypersensitivity | |
dc.subject.mesh | Signal Transduction | |
dc.subject.mesh | Virus Diseases | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Virus Diseases | |
dc.subject.mesh | Asthma | |
dc.subject.mesh | Pulmonary Disease, Chronic Obstructive | |
dc.subject.mesh | Respiratory Hypersensitivity | |
dc.subject.mesh | Interleukin-13 | |
dc.subject.mesh | Antiviral Agents | |
dc.subject.mesh | Signal Transduction | |
dc.subject.mesh | Immunity, Innate | |
dc.subject.mesh | Molecular Targeted Therapy | |
dc.subject.mesh | Interleukin-33 | |
dc.title | Targeting the IL-33/IL-13 Axis for Respiratory Viral Infections. | |
dc.type | Journal Article | |
utslib.citation.volume | 37 | |
utslib.location.activity | England | |
utslib.for | 06 Biological Sciences | |
utslib.for | 11 Medical and Health Sciences | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2022-08-11T06:31:35Z | |
pubs.issue | 4 | |
pubs.publication-status | Published | |
pubs.volume | 37 | |
utslib.citation.issue | 4 |
Abstract:
Lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are highly prevalent worldwide. One of the major factors that limits the efficacy of current medication in these patients are viral infections, leading to exacerbations of symptoms and decreased quality of life. Current pharmacological strategies targeting virus-induced lung disease are problematic due to antiviral resistance and the requirement for strain-specific vaccination. Thus, new therapeutic strategies are urgently required. In this Opinion article, we provide state-of-the-art evidence from humans and preclinical animal models implicating the interleukin (IL)-33/IL-13 axis in virus-induced lung disease. Thus, targeting the IL-33/IL-13 axis may be a feasible way to overcome the limitations of current therapy used to treat virus-induced exacerbations of lung disease.
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