Better colonisation of newly emerged Bordetella pertussis in the co-infection mouse model study.

Safarchi, A; Octavia, S; Luu, LDW; Tay, CY; Sintchenko, V; Wood, N; Marshall, H; McIntyre, P; Lan, R

Better colonisation of newly emerged Bordetella pertussis in the co-infection mouse model study.

Safarchi, A Octavia, S Luu, LDW Tay, CY Sintchenko, V Wood, N Marshall, H McIntyre, P Lan, R

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Publisher:: ELSEVIER SCI LTD
Publication Type:: Journal Article
Citation:: Vaccine, 2016, 34, (34), pp. 3967-3971
Issue Date:: 2016-07-25

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Field	Value	Language
dc.contributor.author	Safarchi, A
dc.contributor.author	Octavia, S
dc.contributor.author	Luu, LDW
dc.contributor.author	Tay, CY
dc.contributor.author	Sintchenko, V
dc.contributor.author	Wood, N
dc.contributor.author	Marshall, H
dc.contributor.author	McIntyre, P
dc.contributor.author	Lan, R
dc.date.accessioned	2022-08-11T08:37:30Z
dc.date.available	2016-06-16
dc.date.available	2022-08-11T08:37:30Z
dc.date.issued	2016-07-25
dc.identifier.citation	Vaccine, 2016, 34, (34), pp. 3967-3971
dc.identifier.issn	0264-410X
dc.identifier.issn	1873-2518
dc.identifier.uri	http://hdl.handle.net/10453/159959
dc.description.abstract	Molecular epidemiological data indicates that the resurgence of pertussis (whooping cough) in populations with high vaccine coverage is associated with genomic adaptation of Bordetella pertussis, the causative agent of the disease, to vaccine selection pressure. We have previously shown that in the period after the introduction of acellular pertussis vaccine (ACV), the majority of circulating strains in Australia switched to single nucleotide polymorphism (SNP) cluster I (carrying ptxP3/prn2), replacing SNP cluster II (carrying ptxP1/prn3). In this study, we carried out an in vivo competition assay using a mouse model infected with SNP cluster I and II B. pertussis strains from Australia. We found that the SNP cluster I strain colonised better than the SNP cluster II strain, in both naïve and immunised mice, suggesting that SNP cluster I strains had better fitness regardless of immunisation status of the host, consistent with SNP cluster I strains replacing SNP cluster II. Nevertheless, we found that ACV enhanced clearance of both SNP cluster I and II strains from the mouse respiratory tract.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER SCI LTD
dc.relation.ispartof	Vaccine
dc.relation.isbasedon	10.1016/j.vaccine.2016.06.052
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	06 Biological Sciences, 07 Agricultural and Veterinary Sciences, 11 Medical and Health Sciences
dc.subject.classification	Virology
dc.subject.mesh	Animals
dc.subject.mesh	Australia
dc.subject.mesh	Bordetella pertussis
dc.subject.mesh	Coinfection
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Evolution, Molecular
dc.subject.mesh	Female
dc.subject.mesh	Genetic Fitness
dc.subject.mesh	Mice
dc.subject.mesh	Mice, Inbred BALB C
dc.subject.mesh	Pertussis Vaccine
dc.subject.mesh	Polymorphism, Single Nucleotide
dc.subject.mesh	Respiratory System
dc.subject.mesh	Selection, Genetic
dc.subject.mesh	Whooping Cough
dc.subject.mesh	Respiratory System
dc.subject.mesh	Animals
dc.subject.mesh	Mice, Inbred BALB C
dc.subject.mesh	Mice
dc.subject.mesh	Bordetella pertussis
dc.subject.mesh	Whooping Cough
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Pertussis Vaccine
dc.subject.mesh	Evolution, Molecular
dc.subject.mesh	Polymorphism, Single Nucleotide
dc.subject.mesh	Australia
dc.subject.mesh	Female
dc.subject.mesh	Selection, Genetic
dc.subject.mesh	Genetic Fitness
dc.subject.mesh	Coinfection
dc.title	Better colonisation of newly emerged Bordetella pertussis in the co-infection mouse model study.
dc.type	Journal Article
utslib.citation.volume	34
utslib.location.activity	Netherlands
utslib.for	06 Biological Sciences
utslib.for	07 Agricultural and Veterinary Sciences
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2022-08-11T08:37:29Z
pubs.issue	34
pubs.publication-status	Published
pubs.volume	34
utslib.citation.issue	34

Abstract:

Molecular epidemiological data indicates that the resurgence of pertussis (whooping cough) in populations with high vaccine coverage is associated with genomic adaptation of Bordetella pertussis, the causative agent of the disease, to vaccine selection pressure. We have previously shown that in the period after the introduction of acellular pertussis vaccine (ACV), the majority of circulating strains in Australia switched to single nucleotide polymorphism (SNP) cluster I (carrying ptxP3/prn2), replacing SNP cluster II (carrying ptxP1/prn3). In this study, we carried out an in vivo competition assay using a mouse model infected with SNP cluster I and II B. pertussis strains from Australia. We found that the SNP cluster I strain colonised better than the SNP cluster II strain, in both naïve and immunised mice, suggesting that SNP cluster I strains had better fitness regardless of immunisation status of the host, consistent with SNP cluster I strains replacing SNP cluster II. Nevertheless, we found that ACV enhanced clearance of both SNP cluster I and II strains from the mouse respiratory tract.

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http://hdl.handle.net/10453/159959