One-Step Loading of Gold and Gd2O3 Nanoparticles within PEGylated Polyethylenimine for Dual Mode Computed Tomography/Magnetic Resonance Imaging of Tumors.

Li, D; Wen, S; Sun, W; Zhang, J; Jin, D; Peng, C; Shen, M; Shi, X

One-Step Loading of Gold and Gd2O3 Nanoparticles within PEGylated Polyethylenimine for Dual Mode Computed Tomography/Magnetic Resonance Imaging of Tumors.

Li, D Wen, S

Sun, W Zhang, J Jin, D

Peng, C Shen, M Shi, X

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Publisher:: American Chemical Society (ACS)
Publication Type:: Journal Article
Citation:: ACS Appl Bio Mater, 2018, 1, (2), pp. 221-225
Issue Date:: 2018-08-20

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Field	Value	Language
dc.contributor.author	Li, D
dc.contributor.author	Wen, S https://orcid.org/0000-0002-4670-4658
dc.contributor.author	Sun, W
dc.contributor.author	Zhang, J
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666
dc.contributor.author	Peng, C
dc.contributor.author	Shen, M
dc.contributor.author	Shi, X
dc.date.accessioned	2022-08-25T20:23:45Z
dc.date.available	2022-08-25T20:23:45Z
dc.date.issued	2018-08-20
dc.identifier.citation	ACS Appl Bio Mater, 2018, 1, (2), pp. 221-225
dc.identifier.issn	2576-6422
dc.identifier.issn	2576-6422
dc.identifier.uri	http://hdl.handle.net/10453/160874
dc.description.abstract	We report here a facile method for one-step loading of gold (Au) and gadolinium oxide (Gd2O3) nanoparticles (NPs) within polyethylenimine (PEI) premodified with polyethtylene glycol (PEG) for dual mode computed tomography (CT) and magnetic resonance (MR) imaging of tumors. PEGylated PEI was used as a template to complex Au(III) and Gd(III) salts, followed by sodium borohydride reduction and acetylation of remaining PEI surface amines to generate the hybrid PEI@Au/Gd2O3 NPs. The hybrid NPs exhibit a remarkable colloidal stability and cytocompatibility and possess a high X-ray attenuation efficacy and r1 relaxivity, enabling their uses for dual mode CT/MR imaging of tumors.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	American Chemical Society (ACS)
dc.relation.ispartof	ACS Appl Bio Mater
dc.relation.isbasedon	10.1021/acsabm.8b00265
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	One-Step Loading of Gold and Gd2O3 Nanoparticles within PEGylated Polyethylenimine for Dual Mode Computed Tomography/Magnetic Resonance Imaging of Tumors.
dc.type	Journal Article
utslib.citation.volume	1
utslib.location.activity	United States
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
dc.date.updated	2022-08-25T20:23:43Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	1
utslib.citation.issue	2

Abstract:

We report here a facile method for one-step loading of gold (Au) and gadolinium oxide (Gd2O3) nanoparticles (NPs) within polyethylenimine (PEI) premodified with polyethtylene glycol (PEG) for dual mode computed tomography (CT) and magnetic resonance (MR) imaging of tumors. PEGylated PEI was used as a template to complex Au(III) and Gd(III) salts, followed by sodium borohydride reduction and acetylation of remaining PEI surface amines to generate the hybrid PEI@Au/Gd2O3 NPs. The hybrid NPs exhibit a remarkable colloidal stability and cytocompatibility and possess a high X-ray attenuation efficacy and r1 relaxivity, enabling their uses for dual mode CT/MR imaging of tumors.

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http://hdl.handle.net/10453/160874