A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease.

Don, EK; Formella, I; Badrock, AP; Hall, TE; Morsch, M; Hortle, E; Hogan, A; Chow, S; Gwee, SSL; Stoddart, JJ; Nicholson, G; Chung, R; Cole, NJ

A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease.

Don, EK Formella, I Badrock, AP Hall, TE Morsch, M Hortle, E

Hogan, A Chow, S Gwee, SSL Stoddart, JJ Nicholson, G Chung, R Cole, NJ

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Publisher:: Mary Ann Liebert
Publication Type:: Journal Article
Citation:: Zebrafish, 2017, 14, (1), pp. 69-72
Issue Date:: 2017-02

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Field	Value	Language
dc.contributor.author	Don, EK
dc.contributor.author	Formella, I
dc.contributor.author	Badrock, AP
dc.contributor.author	Hall, TE
dc.contributor.author	Morsch, M
dc.contributor.author	Hortle, E https://orcid.org/0000-0001-9633-5638
dc.contributor.author	Hogan, A
dc.contributor.author	Chow, S
dc.contributor.author	Gwee, SSL
dc.contributor.author	Stoddart, JJ
dc.contributor.author	Nicholson, G
dc.contributor.author	Chung, R
dc.contributor.author	Cole, NJ
dc.date.accessioned	2022-09-02T05:24:41Z
dc.date.available	2022-09-02T05:24:41Z
dc.date.issued	2017-02
dc.identifier.citation	Zebrafish, 2017, 14, (1), pp. 69-72
dc.identifier.issn	1545-8547
dc.identifier.issn	1557-8542
dc.identifier.uri	http://hdl.handle.net/10453/161221
dc.description.abstract	Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover effective therapeutics. We have generated a Tol2 Gateway-compatible toolbox to study neurodegenerative disorders in zebrafish, which includes promoters for astrocytes, microglia and motor neurons, multiple fluorophores, and compatibility for the introduction of genes of interest or disease-linked genes. This toolbox will advance the rapid and flexible generation of zebrafish models to discover the biology of the nervous system and the disease processes that lead to neurodegeneration.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Mary Ann Liebert
dc.relation.ispartof	Zebrafish
dc.relation.isbasedon	10.1089/zeb.2016.1321
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0608 Zoology
dc.subject.classification	Developmental Biology
dc.subject.mesh	Animals
dc.subject.mesh	Animals, Genetically Modified
dc.subject.mesh	DNA Transposable Elements
dc.subject.mesh	DNA, Recombinant
dc.subject.mesh	Gene Transfer Techniques
dc.subject.mesh	Genetic Vectors
dc.subject.mesh	Green Fluorescent Proteins
dc.subject.mesh	Nervous System Diseases
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Promoter Regions, Genetic
dc.subject.mesh	Recombination, Genetic
dc.subject.mesh	Zebrafish
dc.subject.mesh	Animals
dc.subject.mesh	Animals, Genetically Modified
dc.subject.mesh	DNA Transposable Elements
dc.subject.mesh	DNA, Recombinant
dc.subject.mesh	Gene Transfer Techniques
dc.subject.mesh	Genetic Vectors
dc.subject.mesh	Green Fluorescent Proteins
dc.subject.mesh	Nervous System Diseases
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Promoter Regions, Genetic
dc.subject.mesh	Recombination, Genetic
dc.subject.mesh	Zebrafish
dc.subject.mesh	Animals
dc.subject.mesh	Animals, Genetically Modified
dc.subject.mesh	Zebrafish
dc.subject.mesh	Nervous System Diseases
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Green Fluorescent Proteins
dc.subject.mesh	DNA, Recombinant
dc.subject.mesh	DNA Transposable Elements
dc.subject.mesh	Gene Transfer Techniques
dc.subject.mesh	Recombination, Genetic
dc.subject.mesh	Genetic Vectors
dc.subject.mesh	Promoter Regions, Genetic
dc.title	A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease.
dc.type	Journal Article
utslib.citation.volume	14
utslib.location.activity	United States
utslib.for	0608 Zoology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-09-02T05:24:40Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	14
utslib.citation.issue	1

Abstract:

Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover effective therapeutics. We have generated a Tol2 Gateway-compatible toolbox to study neurodegenerative disorders in zebrafish, which includes promoters for astrocytes, microglia and motor neurons, multiple fluorophores, and compatibility for the introduction of genes of interest or disease-linked genes. This toolbox will advance the rapid and flexible generation of zebrafish models to discover the biology of the nervous system and the disease processes that lead to neurodegeneration.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/161221