Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models.
- Publisher:
- ELSEVIER SCI LTD
- Publication Type:
- Journal Article
- Citation:
- Dev Comp Immunol, 2018, 88, pp. 169-172
- Issue Date:
- 2018-11
Closed Access
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1-s2.0-S0145305X18302283-main.pdf | Published version | 805.33 kB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Johansen, MD | |
dc.contributor.author | Kasparian, JA | |
dc.contributor.author |
Hortle, E |
|
dc.contributor.author | Britton, WJ | |
dc.contributor.author | Purdie, AC | |
dc.contributor.author | Oehlers, SH | |
dc.date.accessioned | 2022-09-05T22:47:55Z | |
dc.date.available | 2018-07-20 | |
dc.date.available | 2022-09-05T22:47:55Z | |
dc.date.issued | 2018-11 | |
dc.identifier.citation | Dev Comp Immunol, 2018, 88, pp. 169-172 | |
dc.identifier.issn | 0145-305X | |
dc.identifier.issn | 1879-0089 | |
dc.identifier.uri | http://hdl.handle.net/10453/161390 | |
dc.description.abstract | Host lipid metabolism is an important target for subversion by pathogenic mycobacteria such as Mycobacterium tuberculosis. The appearance of foam cells within the granuloma are well-characterised effects of chronic tuberculosis. The zebrafish-Mycobacterium marinum infection model recapitulates many aspects of human-M. tuberculosis infection and is used as a model to investigate the structural components of the mycobacterial granuloma. Here, we demonstrate that the zebrafish-M. marinum granuloma contains foam cells and that the transdifferentiation of macrophages into foam cells is driven by the mycobacterial ESX1 pathogenicity locus. This report demonstrates conservation of an important aspect of mycobacterial infection across species. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | ELSEVIER SCI LTD | |
dc.relation.ispartof | Dev Comp Immunol | |
dc.relation.isbasedon | 10.1016/j.dci.2018.07.022 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 1107 Immunology | |
dc.subject.classification | Immunology | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Antigens, Bacterial | |
dc.subject.mesh | Bacterial Proteins | |
dc.subject.mesh | Cell Transdifferentiation | |
dc.subject.mesh | Disease Models, Animal | |
dc.subject.mesh | Foam Cells | |
dc.subject.mesh | Granuloma | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Lipid Metabolism | |
dc.subject.mesh | Macrophages | |
dc.subject.mesh | Mycobacterium Infections, Nontuberculous | |
dc.subject.mesh | Mycobacterium marinum | |
dc.subject.mesh | Mycobacterium tuberculosis | |
dc.subject.mesh | Tuberculosis | |
dc.subject.mesh | Zebrafish | |
dc.subject.mesh | Macrophages | |
dc.subject.mesh | Foam Cells | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Zebrafish | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Mycobacterium marinum | |
dc.subject.mesh | Mycobacterium tuberculosis | |
dc.subject.mesh | Tuberculosis | |
dc.subject.mesh | Granuloma | |
dc.subject.mesh | Disease Models, Animal | |
dc.subject.mesh | Bacterial Proteins | |
dc.subject.mesh | Antigens, Bacterial | |
dc.subject.mesh | Lipid Metabolism | |
dc.subject.mesh | Cell Transdifferentiation | |
dc.subject.mesh | Mycobacterium Infections, Nontuberculous | |
dc.title | Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models. | |
dc.type | Journal Article | |
utslib.citation.volume | 88 | |
utslib.location.activity | United States | |
utslib.for | 1107 Immunology | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2022-09-05T22:47:53Z | |
pubs.publication-status | Published | |
pubs.volume | 88 |
Abstract:
Host lipid metabolism is an important target for subversion by pathogenic mycobacteria such as Mycobacterium tuberculosis. The appearance of foam cells within the granuloma are well-characterised effects of chronic tuberculosis. The zebrafish-Mycobacterium marinum infection model recapitulates many aspects of human-M. tuberculosis infection and is used as a model to investigate the structural components of the mycobacterial granuloma. Here, we demonstrate that the zebrafish-M. marinum granuloma contains foam cells and that the transdifferentiation of macrophages into foam cells is driven by the mycobacterial ESX1 pathogenicity locus. This report demonstrates conservation of an important aspect of mycobacterial infection across species.
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