Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models.

Johansen, MD; Kasparian, JA; Hortle, E; Britton, WJ; Purdie, AC; Oehlers, SH

Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models.

Johansen, MD Kasparian, JA Hortle, E

Britton, WJ Purdie, AC Oehlers, SH

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Publisher:: ELSEVIER SCI LTD
Publication Type:: Journal Article
Citation:: Dev Comp Immunol, 2018, 88, pp. 169-172
Issue Date:: 2018-11

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Field	Value	Language
dc.contributor.author	Johansen, MD
dc.contributor.author	Kasparian, JA
dc.contributor.author	Hortle, E https://orcid.org/0000-0001-9633-5638
dc.contributor.author	Britton, WJ
dc.contributor.author	Purdie, AC
dc.contributor.author	Oehlers, SH
dc.date.accessioned	2022-09-05T22:47:55Z
dc.date.available	2018-07-20
dc.date.available	2022-09-05T22:47:55Z
dc.date.issued	2018-11
dc.identifier.citation	Dev Comp Immunol, 2018, 88, pp. 169-172
dc.identifier.issn	0145-305X
dc.identifier.issn	1879-0089
dc.identifier.uri	http://hdl.handle.net/10453/161390
dc.description.abstract	Host lipid metabolism is an important target for subversion by pathogenic mycobacteria such as Mycobacterium tuberculosis. The appearance of foam cells within the granuloma are well-characterised effects of chronic tuberculosis. The zebrafish-Mycobacterium marinum infection model recapitulates many aspects of human-M. tuberculosis infection and is used as a model to investigate the structural components of the mycobacterial granuloma. Here, we demonstrate that the zebrafish-M. marinum granuloma contains foam cells and that the transdifferentiation of macrophages into foam cells is driven by the mycobacterial ESX1 pathogenicity locus. This report demonstrates conservation of an important aspect of mycobacterial infection across species.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER SCI LTD
dc.relation.ispartof	Dev Comp Immunol
dc.relation.isbasedon	10.1016/j.dci.2018.07.022
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1107 Immunology
dc.subject.classification	Immunology
dc.subject.mesh	Animals
dc.subject.mesh	Antigens, Bacterial
dc.subject.mesh	Bacterial Proteins
dc.subject.mesh	Cell Transdifferentiation
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Foam Cells
dc.subject.mesh	Granuloma
dc.subject.mesh	Humans
dc.subject.mesh	Lipid Metabolism
dc.subject.mesh	Macrophages
dc.subject.mesh	Mycobacterium Infections, Nontuberculous
dc.subject.mesh	Mycobacterium marinum
dc.subject.mesh	Mycobacterium tuberculosis
dc.subject.mesh	Tuberculosis
dc.subject.mesh	Zebrafish
dc.subject.mesh	Macrophages
dc.subject.mesh	Foam Cells
dc.subject.mesh	Animals
dc.subject.mesh	Zebrafish
dc.subject.mesh	Humans
dc.subject.mesh	Mycobacterium marinum
dc.subject.mesh	Mycobacterium tuberculosis
dc.subject.mesh	Tuberculosis
dc.subject.mesh	Granuloma
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Bacterial Proteins
dc.subject.mesh	Antigens, Bacterial
dc.subject.mesh	Lipid Metabolism
dc.subject.mesh	Cell Transdifferentiation
dc.subject.mesh	Mycobacterium Infections, Nontuberculous
dc.title	Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models.
dc.type	Journal Article
utslib.citation.volume	88
utslib.location.activity	United States
utslib.for	1107 Immunology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2022-09-05T22:47:53Z
pubs.publication-status	Published
pubs.volume	88

Abstract:

Host lipid metabolism is an important target for subversion by pathogenic mycobacteria such as Mycobacterium tuberculosis. The appearance of foam cells within the granuloma are well-characterised effects of chronic tuberculosis. The zebrafish-Mycobacterium marinum infection model recapitulates many aspects of human-M. tuberculosis infection and is used as a model to investigate the structural components of the mycobacterial granuloma. Here, we demonstrate that the zebrafish-M. marinum granuloma contains foam cells and that the transdifferentiation of macrophages into foam cells is driven by the mycobacterial ESX1 pathogenicity locus. This report demonstrates conservation of an important aspect of mycobacterial infection across species.

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http://hdl.handle.net/10453/161390