Multifunctional Hybrid Nanoparticles for Traceable Drug Delivery and Intracellular Microenvironment-Controlled Multistage Drug-Release in Neurons.

Shi, B; Du, X; Chen, J; Fu, L; Morsch, M; Lee, A; Liu, Y; Cole, N; Chung, R

Multifunctional Hybrid Nanoparticles for Traceable Drug Delivery and Intracellular Microenvironment-Controlled Multistage Drug-Release in Neurons.

Shi, B Du, X Chen, J Fu, L

Morsch, M Lee, A Liu, Y Cole, N Chung, R

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Small, 2017, 13, (20), pp. 2-10
Issue Date:: 2017-05

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Field	Value	Language
dc.contributor.author	Shi, B
dc.contributor.author	Du, X
dc.contributor.author	Chen, J
dc.contributor.author	Fu, L https://orcid.org/0000-0001-8871-358X
dc.contributor.author	Morsch, M
dc.contributor.author	Lee, A
dc.contributor.author	Liu, Y
dc.contributor.author	Cole, N
dc.contributor.author	Chung, R
dc.date.accessioned	2022-09-06T01:00:56Z
dc.date.available	2022-09-06T01:00:56Z
dc.date.issued	2017-05
dc.identifier.citation	Small, 2017, 13, (20), pp. 2-10
dc.identifier.issn	1613-6810
dc.identifier.issn	1613-6829
dc.identifier.uri	http://hdl.handle.net/10453/161401
dc.description.abstract	Innovative nanoparticles hold promising potential for disease therapy as drug delivery systems. For brain-disease therapy, a drug delivery system that can sustainably control drug-release and monitor fluorescence of the drug cargos is highly desirable. In this study, a light-traceable and intracellular microenvironment-responsive drug delivery system was developed based on the combination of glutathione-responsive autoflurescent nanogel, dendrimer-like mesoporous silica nanoparticles, and gold nanoparticles. The resulting hybrid nanoparticles represent a new class of delivery system that can efficiently load, transport, and control multistage-release of sulfydryl-containing drugs into neurons, with light-traceable monitoring for future brain-disease therapy.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	Small
dc.relation.isbasedon	10.1002/smll.201603966
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Nanoscience & Nanotechnology
dc.subject.mesh	Animals
dc.subject.mesh	Carbon-13 Magnetic Resonance Spectroscopy
dc.subject.mesh	Cell Line
dc.subject.mesh	Cellular Microenvironment
dc.subject.mesh	Drug Carriers
dc.subject.mesh	Drug Delivery Systems
dc.subject.mesh	Drug Liberation
dc.subject.mesh	Fluorescence
dc.subject.mesh	Intracellular Space
dc.subject.mesh	Metal Nanoparticles
dc.subject.mesh	Mice
dc.subject.mesh	Neurons
dc.subject.mesh	Porosity
dc.subject.mesh	Silicon Dioxide
dc.subject.mesh	Surface Properties
dc.subject.mesh	Animals
dc.subject.mesh	Carbon-13 Magnetic Resonance Spectroscopy
dc.subject.mesh	Cell Line
dc.subject.mesh	Cellular Microenvironment
dc.subject.mesh	Drug Carriers
dc.subject.mesh	Drug Delivery Systems
dc.subject.mesh	Drug Liberation
dc.subject.mesh	Fluorescence
dc.subject.mesh	Intracellular Space
dc.subject.mesh	Metal Nanoparticles
dc.subject.mesh	Mice
dc.subject.mesh	Neurons
dc.subject.mesh	Porosity
dc.subject.mesh	Silicon Dioxide
dc.subject.mesh	Surface Properties
dc.subject.mesh	Neurons
dc.subject.mesh	Cell Line
dc.subject.mesh	Intracellular Space
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Silicon Dioxide
dc.subject.mesh	Drug Carriers
dc.subject.mesh	Drug Delivery Systems
dc.subject.mesh	Surface Properties
dc.subject.mesh	Fluorescence
dc.subject.mesh	Porosity
dc.subject.mesh	Metal Nanoparticles
dc.subject.mesh	Cellular Microenvironment
dc.subject.mesh	Drug Liberation
dc.subject.mesh	Carbon-13 Magnetic Resonance Spectroscopy
dc.title	Multifunctional Hybrid Nanoparticles for Traceable Drug Delivery and Intracellular Microenvironment-Controlled Multistage Drug-Release in Neurons.
dc.type	Journal Article
utslib.citation.volume	13
utslib.location.activity	Germany
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-09-06T01:00:53Z
pubs.issue	20
pubs.publication-status	Published
pubs.volume	13
utslib.citation.issue	20

Abstract:

Innovative nanoparticles hold promising potential for disease therapy as drug delivery systems. For brain-disease therapy, a drug delivery system that can sustainably control drug-release and monitor fluorescence of the drug cargos is highly desirable. In this study, a light-traceable and intracellular microenvironment-responsive drug delivery system was developed based on the combination of glutathione-responsive autoflurescent nanogel, dendrimer-like mesoporous silica nanoparticles, and gold nanoparticles. The resulting hybrid nanoparticles represent a new class of delivery system that can efficiently load, transport, and control multistage-release of sulfydryl-containing drugs into neurons, with light-traceable monitoring for future brain-disease therapy.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/161401