Peripheral nerve injury impairs the ability to maintain behavioural flexibility following acute stress in the rat.

Mor, D; Kendig, MD; Kang, JWM; Gemikonakli, G; Austin, PJ; Kalman, E; Corbit, LH

Peripheral nerve injury impairs the ability to maintain behavioural flexibility following acute stress in the rat.

Mor, D Kendig, MD Kang, JWM Gemikonakli, G Austin, PJ Kalman, E Corbit, LH

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Behavioural Brain Research, 2017, 328, pp. 123-129
Issue Date:: 2017-06-15

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Field	Value	Language
dc.contributor.author	Mor, D
dc.contributor.author	Kendig, MD
dc.contributor.author	Kang, JWM
dc.contributor.author	Gemikonakli, G
dc.contributor.author	Austin, PJ
dc.contributor.author	Kalman, E
dc.contributor.author	Corbit, LH
dc.date.accessioned	2022-09-06T03:25:18Z
dc.date.available	2017-04-01
dc.date.available	2022-09-06T03:25:18Z
dc.date.issued	2017-06-15
dc.identifier.citation	Behavioural Brain Research, 2017, 328, pp. 123-129
dc.identifier.issn	0166-4328
dc.identifier.issn	1872-7549
dc.identifier.uri	http://hdl.handle.net/10453/161417
dc.description.abstract	Chronic neuropathic pain often leads to impaired cognition and reduced behavioural flexibility. This study used a rat model to investigate if a peripheral nerve injury, with or without an additional acute psychological stress, alters behavioural flexibility and goal directed behaviour as measured by sensitivity to devaluation. Neuropathic pain was induced by a chronic constriction injury (CCI) of the sciatic nerve. CCI, sham-injury and naïve rats were trained to press two levers for two rewards. In outcome devaluation tests, one of the rewards was devalued by pre-feeding it to satiety, immediately prior to an extinction test measuring responding on the two levers. The ability to preferentially direct responding toward the action earning the currently-valued reward was taken as evidence of goal-directed behaviour. To test the impact of acute stress, rats were subjected to 15min restraint following pre-feeding and prior to the devaluation test. Neither CCI surgery nor acute stress alone altered sensitivity to devaluation, but in combination CCI and acute stress significantly reduced sensitivity to devaluation. This Study demonstrates that relatively mild stressors that are without effect in uninjured populations can markedly impair cognition under conditions of chronic pain. It further suggests that overlapping neural substrates regulated by nerve injury and/or acute stress are having a cumulative effect on behavioural flexibility.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Behavioural Brain Research
dc.relation.isbasedon	10.1016/j.bbr.2017.04.003
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences
dc.subject.classification	Neurology & Neurosurgery
dc.subject.mesh	Animals
dc.subject.mesh	Behavior, Animal
dc.subject.mesh	Chronic Pain
dc.subject.mesh	Conditioning, Operant
dc.subject.mesh	Male
dc.subject.mesh	Neuralgia
dc.subject.mesh	Peripheral Nerve Injuries
dc.subject.mesh	Rats, Sprague-Dawley
dc.subject.mesh	Restraint, Physical
dc.subject.mesh	Reward
dc.subject.mesh	Sciatic Nerve
dc.subject.mesh	Stress, Psychological
dc.subject.mesh	Animals
dc.subject.mesh	Behavior, Animal
dc.subject.mesh	Chronic Pain
dc.subject.mesh	Conditioning, Operant
dc.subject.mesh	Male
dc.subject.mesh	Neuralgia
dc.subject.mesh	Peripheral Nerve Injuries
dc.subject.mesh	Rats, Sprague-Dawley
dc.subject.mesh	Restraint, Physical
dc.subject.mesh	Reward
dc.subject.mesh	Sciatic Nerve
dc.subject.mesh	Stress, Psychological
dc.subject.mesh	Sciatic Nerve
dc.subject.mesh	Animals
dc.subject.mesh	Rats, Sprague-Dawley
dc.subject.mesh	Neuralgia
dc.subject.mesh	Restraint, Physical
dc.subject.mesh	Behavior, Animal
dc.subject.mesh	Stress, Psychological
dc.subject.mesh	Conditioning, Operant
dc.subject.mesh	Reward
dc.subject.mesh	Male
dc.subject.mesh	Peripheral Nerve Injuries
dc.subject.mesh	Chronic Pain
dc.title	Peripheral nerve injury impairs the ability to maintain behavioural flexibility following acute stress in the rat.
dc.type	Journal Article
utslib.citation.volume	328
utslib.location.activity	Netherlands
utslib.for	11 Medical and Health Sciences
utslib.for	17 Psychology and Cognitive Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-09-06T03:25:17Z
pubs.publication-status	Published
pubs.volume	328

Abstract:

Chronic neuropathic pain often leads to impaired cognition and reduced behavioural flexibility. This study used a rat model to investigate if a peripheral nerve injury, with or without an additional acute psychological stress, alters behavioural flexibility and goal directed behaviour as measured by sensitivity to devaluation. Neuropathic pain was induced by a chronic constriction injury (CCI) of the sciatic nerve. CCI, sham-injury and naïve rats were trained to press two levers for two rewards. In outcome devaluation tests, one of the rewards was devalued by pre-feeding it to satiety, immediately prior to an extinction test measuring responding on the two levers. The ability to preferentially direct responding toward the action earning the currently-valued reward was taken as evidence of goal-directed behaviour. To test the impact of acute stress, rats were subjected to 15min restraint following pre-feeding and prior to the devaluation test. Neither CCI surgery nor acute stress alone altered sensitivity to devaluation, but in combination CCI and acute stress significantly reduced sensitivity to devaluation. This Study demonstrates that relatively mild stressors that are without effect in uninjured populations can markedly impair cognition under conditions of chronic pain. It further suggests that overlapping neural substrates regulated by nerve injury and/or acute stress are having a cumulative effect on behavioural flexibility.

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http://hdl.handle.net/10453/161417