Impact of Novel Sorghum Bran Diets on DSS-Induced Colitis.

Ritchie, LE; Taddeo, SS; Weeks, BR; Carroll, RJ; Dykes, L; Rooney, LW; Turner, ND

Impact of Novel Sorghum Bran Diets on DSS-Induced Colitis.

Ritchie, LE Taddeo, SS Weeks, BR Carroll, RJ Dykes, L Rooney, LW Turner, ND

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Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: Nutrients, 2017, 9, (4), pp. 1-20
Issue Date:: 2017-03-27

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Field	Value	Language
dc.contributor.author	Ritchie, LE
dc.contributor.author	Taddeo, SS
dc.contributor.author	Weeks, BR
dc.contributor.author	Carroll, RJ
dc.contributor.author	Dykes, L
dc.contributor.author	Rooney, LW
dc.contributor.author	Turner, ND
dc.date.accessioned	2022-09-13T01:24:11Z
dc.date.available	2017-03-20
dc.date.available	2022-09-13T01:24:11Z
dc.date.issued	2017-03-27
dc.identifier.citation	Nutrients, 2017, 9, (4), pp. 1-20
dc.identifier.issn	2072-6643
dc.identifier.issn	2072-6643
dc.identifier.uri	http://hdl.handle.net/10453/161770
dc.description.abstract	We have demonstrated that polyphenol-rich sorghum bran diets alter fecal microbiota; however, little is known regarding their effect on colon inflammation. Our aim was to characterize the effect of sorghum bran diets on intestinal homeostasis during dextran sodium sulfate (DSS)-induced colitis. Male Sprague-Dawley rats (N = 20/diet) were provided diets containing 6% fiber from cellulose, or Black (3-deoxyanthocyanins), Sumac (condensed tannins) or Hi Tannin Black (both) sorghum bran. Colitis was induced (N = 10/diet) with three separate 48-h exposures to 3% DSS, and feces were collected. On Day 82, animals were euthanized and the colon resected. Only discrete mucosal lesions, with no diarrhea or bloody stools, were observed in DSS rats. Only bran diets upregulated proliferation and Tff3, Tgfβ and short chain fatty acids (SCFA) transporter expression after a DSS challenge. DSS did not significantly affect fecal SCFA concentrations. Bran diets alone upregulated repair mechanisms and SCFA transporter expression, which suggests these polyphenol-rich sorghum brans may suppress some consequences of colitis.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI AG
dc.relation.ispartof	Nutrients
dc.relation.isbasedon	10.3390/nu9040330
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0908 Food Sciences, 1111 Nutrition and Dietetics
dc.subject.mesh	Animals
dc.subject.mesh	Apoptosis
dc.subject.mesh	Cell Proliferation
dc.subject.mesh	Colitis
dc.subject.mesh	Dextran Sulfate
dc.subject.mesh	Diet
dc.subject.mesh	Dietary Fiber
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Edible Grain
dc.subject.mesh	Epithelial Cells
dc.subject.mesh	Fatty Acids, Volatile
dc.subject.mesh	Feces
dc.subject.mesh	Intestinal Mucosa
dc.subject.mesh	Male
dc.subject.mesh	NF-kappa B
dc.subject.mesh	Polyphenols
dc.subject.mesh	Rats
dc.subject.mesh	Rats, Sprague-Dawley
dc.subject.mesh	Sorghum
dc.subject.mesh	Transforming Growth Factor beta
dc.subject.mesh	Trefoil Factor-3
dc.subject.mesh	Animals
dc.subject.mesh	Apoptosis
dc.subject.mesh	Cell Proliferation
dc.subject.mesh	Colitis
dc.subject.mesh	Dextran Sulfate
dc.subject.mesh	Diet
dc.subject.mesh	Dietary Fiber
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Edible Grain
dc.subject.mesh	Epithelial Cells
dc.subject.mesh	Fatty Acids, Volatile
dc.subject.mesh	Feces
dc.subject.mesh	Intestinal Mucosa
dc.subject.mesh	Male
dc.subject.mesh	NF-kappa B
dc.subject.mesh	Polyphenols
dc.subject.mesh	Rats
dc.subject.mesh	Rats, Sprague-Dawley
dc.subject.mesh	Sorghum
dc.subject.mesh	Transforming Growth Factor beta
dc.subject.mesh	Trefoil Factor-3
dc.subject.mesh	Intestinal Mucosa
dc.subject.mesh	Epithelial Cells
dc.subject.mesh	Feces
dc.subject.mesh	Animals
dc.subject.mesh	Rats
dc.subject.mesh	Rats, Sprague-Dawley
dc.subject.mesh	Sorghum
dc.subject.mesh	Colitis
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Dextran Sulfate
dc.subject.mesh	Fatty Acids, Volatile
dc.subject.mesh	Transforming Growth Factor beta
dc.subject.mesh	NF-kappa B
dc.subject.mesh	Diet
dc.subject.mesh	Apoptosis
dc.subject.mesh	Cell Proliferation
dc.subject.mesh	Dietary Fiber
dc.subject.mesh	Male
dc.subject.mesh	Polyphenols
dc.subject.mesh	Edible Grain
dc.subject.mesh	Trefoil Factor-3
dc.title	Impact of Novel Sorghum Bran Diets on DSS-Induced Colitis.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	Switzerland
utslib.for	0908 Food Sciences
utslib.for	1111 Nutrition and Dietetics
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-09-13T01:24:00Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	9
utslib.citation.issue	4

Abstract:

We have demonstrated that polyphenol-rich sorghum bran diets alter fecal microbiota; however, little is known regarding their effect on colon inflammation. Our aim was to characterize the effect of sorghum bran diets on intestinal homeostasis during dextran sodium sulfate (DSS)-induced colitis. Male Sprague-Dawley rats (N = 20/diet) were provided diets containing 6% fiber from cellulose, or Black (3-deoxyanthocyanins), Sumac (condensed tannins) or Hi Tannin Black (both) sorghum bran. Colitis was induced (N = 10/diet) with three separate 48-h exposures to 3% DSS, and feces were collected. On Day 82, animals were euthanized and the colon resected. Only discrete mucosal lesions, with no diarrhea or bloody stools, were observed in DSS rats. Only bran diets upregulated proliferation and Tff3, Tgfβ and short chain fatty acids (SCFA) transporter expression after a DSS challenge. DSS did not significantly affect fecal SCFA concentrations. Bran diets alone upregulated repair mechanisms and SCFA transporter expression, which suggests these polyphenol-rich sorghum brans may suppress some consequences of colitis.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/161770