Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis.
- Publisher:
- PERGAMON-ELSEVIER SCIENCE LTD
- Publication Type:
- Journal Article
- Citation:
- Bioorg Med Chem, 2016, 24, (7), pp. 1520-1527
- Issue Date:
- 2016-04-01
Closed Access
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1-s2.0-S096808961630102X-main.pdf | Published version | 1.09 MB |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Browne, EC | |
dc.contributor.author | Parakh, S | |
dc.contributor.author | Duncan, LF | |
dc.contributor.author | Langford, SJ | |
dc.contributor.author | Atkin, JD | |
dc.contributor.author | Abbott, BM | |
dc.date.accessioned | 2022-10-24T06:21:16Z | |
dc.date.available | 2016-02-17 | |
dc.date.available | 2022-10-24T06:21:16Z | |
dc.date.issued | 2016-04-01 | |
dc.identifier.citation | Bioorg Med Chem, 2016, 24, (7), pp. 1520-1527 | |
dc.identifier.issn | 0968-0896 | |
dc.identifier.issn | 1464-3391 | |
dc.identifier.uri | http://hdl.handle.net/10453/162638 | |
dc.description.abstract | Cellular studies have been undertaken on a nonamer peptide nucleic acid (PNA) sequence, which binds to mRNA encoding superoxide dismutase 1, and a series of peptide nucleic acids conjugated to synthetic lipophilic vitamin analogs including a recently prepared menadione (vitamin K) analog. Reduction of both mutant superoxide dismutase 1 inclusion formation and endoplasmic reticulum stress, two of the key cellular pathological hallmarks in amyotrophic lateral sclerosis, by two of the prepared PNA oligomers is reported for the first time. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | |
dc.relation | http://purl.org/au-research/grants/arc/DP0771578 | |
dc.relation.ispartof | Bioorg Med Chem | |
dc.relation.isbasedon | 10.1016/j.bmc.2016.02.022 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry, 1115 Pharmacology and Pharmaceutical Sciences | |
dc.subject.classification | Medicinal & Biomolecular Chemistry | |
dc.subject.mesh | Amyotrophic Lateral Sclerosis | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Cells, Cultured | |
dc.subject.mesh | Endoplasmic Reticulum Stress | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Peptide Nucleic Acids | |
dc.subject.mesh | Superoxide Dismutase | |
dc.subject.mesh | Superoxide Dismutase-1 | |
dc.subject.mesh | Thermodynamics | |
dc.subject.mesh | Vitamins | |
dc.subject.mesh | Cells, Cultured | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Amyotrophic Lateral Sclerosis | |
dc.subject.mesh | Superoxide Dismutase | |
dc.subject.mesh | Vitamins | |
dc.subject.mesh | Peptide Nucleic Acids | |
dc.subject.mesh | Thermodynamics | |
dc.subject.mesh | Endoplasmic Reticulum Stress | |
dc.subject.mesh | Superoxide Dismutase-1 | |
dc.title | Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis. | |
dc.type | Journal Article | |
utslib.citation.volume | 24 | |
utslib.location.activity | England | |
utslib.for | 0304 Medicinal and Biomolecular Chemistry | |
utslib.for | 0305 Organic Chemistry | |
utslib.for | 1115 Pharmacology and Pharmaceutical Sciences | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences | |
pubs.organisational-group | /University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2022-10-24T06:21:15Z | |
pubs.issue | 7 | |
pubs.publication-status | Published | |
pubs.volume | 24 | |
utslib.citation.issue | 7 |
Abstract:
Cellular studies have been undertaken on a nonamer peptide nucleic acid (PNA) sequence, which binds to mRNA encoding superoxide dismutase 1, and a series of peptide nucleic acids conjugated to synthetic lipophilic vitamin analogs including a recently prepared menadione (vitamin K) analog. Reduction of both mutant superoxide dismutase 1 inclusion formation and endoplasmic reticulum stress, two of the key cellular pathological hallmarks in amyotrophic lateral sclerosis, by two of the prepared PNA oligomers is reported for the first time.
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