Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis.

Publisher:
PERGAMON-ELSEVIER SCIENCE LTD
Publication Type:
Journal Article
Citation:
Bioorg Med Chem, 2016, 24, (7), pp. 1520-1527
Issue Date:
2016-04-01
Filename Description Size
1-s2.0-S096808961630102X-main.pdfPublished version1.09 MB
Full metadata record
Cellular studies have been undertaken on a nonamer peptide nucleic acid (PNA) sequence, which binds to mRNA encoding superoxide dismutase 1, and a series of peptide nucleic acids conjugated to synthetic lipophilic vitamin analogs including a recently prepared menadione (vitamin K) analog. Reduction of both mutant superoxide dismutase 1 inclusion formation and endoplasmic reticulum stress, two of the key cellular pathological hallmarks in amyotrophic lateral sclerosis, by two of the prepared PNA oligomers is reported for the first time.
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