Exploring the Pro-Phagocytic and Anti-Inflammatory Functions of PACAP and VIP in Microglia: Implications for Multiple Sclerosis.

Jansen, MI; Thomas Broome, S; Castorina, A

Exploring the Pro-Phagocytic and Anti-Inflammatory Functions of PACAP and VIP in Microglia: Implications for Multiple Sclerosis.

Jansen, MI Thomas Broome, S Castorina, A

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Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: International Journal of Molecular Sciences, 2022, 23, (9), pp. 1-23
Issue Date:: 2022-04-26

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Field	Value	Language
dc.contributor.author	Jansen, MI
dc.contributor.author	Thomas Broome, S
dc.contributor.author	Castorina, A https://orcid.org/0000-0001-7037-759X
dc.date.accessioned	2022-11-07T04:26:07Z
dc.date.available	2022-04-25
dc.date.available	2022-11-07T04:26:07Z
dc.date.issued	2022-04-26
dc.identifier.citation	International Journal of Molecular Sciences, 2022, 23, (9), pp. 1-23
dc.identifier.issn	1422-0067
dc.identifier.issn	1422-0067
dc.identifier.uri	http://hdl.handle.net/10453/163280
dc.description.abstract	Multiple sclerosis (MS) is a chronic neuroinflammatory and demyelinating disease of the central nervous system (CNS), characterised by the infiltration of peripheral immune cells, multifocal white-matter lesions, and neurodegeneration. In recent years, microglia have emerged as key contributors to MS pathology, acting as scavengers of toxic myelin/cell debris and modulating the inflammatory microenvironment to promote myelin repair. In this review, we explore the role of two neuropeptides, pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP), as important regulators of microglial functioning during demyelination, myelin phagocytosis, and remyelination, emphasising the potential of these neuropeptides as therapeutic targets for the treatment of MS.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI AG
dc.relation.ispartof	International Journal of Molecular Sciences
dc.relation.isbasedon	10.3390/ijms23094788
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0399 Other Chemical Sciences, 0604 Genetics, 0699 Other Biological Sciences
dc.subject.classification	Chemical Physics
dc.subject.mesh	Humans
dc.subject.mesh	Microglia
dc.subject.mesh	Multiple Sclerosis
dc.subject.mesh	Pituitary Adenylate Cyclase-Activating Polypeptide
dc.subject.mesh	Vasoactive Intestinal Peptide
dc.subject.mesh	Humans
dc.subject.mesh	Microglia
dc.subject.mesh	Multiple Sclerosis
dc.subject.mesh	Pituitary Adenylate Cyclase-Activating Polypeptide
dc.subject.mesh	Vasoactive Intestinal Peptide
dc.subject.mesh	Microglia
dc.subject.mesh	Humans
dc.subject.mesh	Multiple Sclerosis
dc.subject.mesh	Vasoactive Intestinal Peptide
dc.subject.mesh	Pituitary Adenylate Cyclase-Activating Polypeptide
dc.title	Exploring the Pro-Phagocytic and Anti-Inflammatory Functions of PACAP and VIP in Microglia: Implications for Multiple Sclerosis.
dc.type	Journal Article
utslib.citation.volume	23
utslib.location.activity	Switzerland
utslib.for	0399 Other Chemical Sciences
utslib.for	0604 Genetics
utslib.for	0699 Other Biological Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-11-07T04:26:03Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	23
utslib.citation.issue	9

Abstract:

Multiple sclerosis (MS) is a chronic neuroinflammatory and demyelinating disease of the central nervous system (CNS), characterised by the infiltration of peripheral immune cells, multifocal white-matter lesions, and neurodegeneration. In recent years, microglia have emerged as key contributors to MS pathology, acting as scavengers of toxic myelin/cell debris and modulating the inflammatory microenvironment to promote myelin repair. In this review, we explore the role of two neuropeptides, pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP), as important regulators of microglial functioning during demyelination, myelin phagocytosis, and remyelination, emphasising the potential of these neuropeptides as therapeutic targets for the treatment of MS.

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http://hdl.handle.net/10453/163280