A brief history of brain iron accumulation in Parkinson disease and related disorders.
- Publisher:
- Springer
- Publication Type:
- Journal Article
- Citation:
- Journal of Neural Transmission, 2022, 129, (5-6), pp. 505-520
- Issue Date:
- 2022-06
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Foley, PB | |
dc.contributor.author | Hare, DJ | |
dc.contributor.author | Double, KL | |
dc.date.accessioned | 2022-11-22T02:41:26Z | |
dc.date.available | 2022-04-22 | |
dc.date.available | 2022-11-22T02:41:26Z | |
dc.date.issued | 2022-06 | |
dc.identifier.citation | Journal of Neural Transmission, 2022, 129, (5-6), pp. 505-520 | |
dc.identifier.issn | 0300-9564 | |
dc.identifier.issn | 1435-1463 | |
dc.identifier.uri | http://hdl.handle.net/10453/163644 | |
dc.description.abstract | Iron has a long and storied history in Parkinson disease and related disorders. This essential micronutrient is critical for normal brain function, but abnormal brain iron accumulation has been associated with extrapyramidal disease for a century. Precisely why, how, and when iron is implicated in neuronal death remains the subject of investigation. In this article, we review the history of iron in movement disorders, from the first observations in the early twentieth century to recent efforts that view extrapyramidal iron as a novel therapeutic target and diagnostic indicator. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Springer | |
dc.relation.ispartof | Journal of Neural Transmission | |
dc.relation.isbasedon | 10.1007/s00702-022-02505-5 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 1109 Neurosciences, 1701 Psychology | |
dc.subject.classification | Neurology & Neurosurgery | |
dc.subject.mesh | Basal Ganglia Diseases | |
dc.subject.mesh | Brain | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Iron | |
dc.subject.mesh | Parkinson Disease | |
dc.subject.mesh | Substantia Nigra | |
dc.subject.mesh | Basal Ganglia Diseases | |
dc.subject.mesh | Brain | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Iron | |
dc.subject.mesh | Parkinson Disease | |
dc.subject.mesh | Substantia Nigra | |
dc.subject.mesh | Brain | |
dc.subject.mesh | Substantia Nigra | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Basal Ganglia Diseases | |
dc.subject.mesh | Parkinson Disease | |
dc.subject.mesh | Iron | |
dc.title | A brief history of brain iron accumulation in Parkinson disease and related disorders. | |
dc.type | Journal Article | |
utslib.citation.volume | 129 | |
utslib.location.activity | Austria | |
utslib.for | 1109 Neurosciences | |
utslib.for | 1701 Psychology | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences | |
utslib.copyright.status | open_access | * |
pubs.consider-herdc | false | |
dc.date.updated | 2022-11-22T02:41:22Z | |
pubs.issue | 5-6 | |
pubs.publication-status | Published | |
pubs.volume | 129 | |
utslib.citation.issue | 5-6 |
Abstract:
Iron has a long and storied history in Parkinson disease and related disorders. This essential micronutrient is critical for normal brain function, but abnormal brain iron accumulation has been associated with extrapyramidal disease for a century. Precisely why, how, and when iron is implicated in neuronal death remains the subject of investigation. In this article, we review the history of iron in movement disorders, from the first observations in the early twentieth century to recent efforts that view extrapyramidal iron as a novel therapeutic target and diagnostic indicator.
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