The Changes in Cyanobacterial Concentration of β-Methylamino-L-Alanine during a Bloom Event.

Peters, SJ; Rodgers, KJ; Mitrovic, SM; Bishop, DP

The Changes in Cyanobacterial Concentration of β-Methylamino-L-Alanine during a Bloom Event.

Peters, SJ Rodgers, KJ Mitrovic, SM Bishop, DP

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Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: Molecules, 2022, 27, (21), pp. 1-11
Issue Date:: 2022-10-30

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Field	Value	Language
dc.contributor.author	Peters, SJ
dc.contributor.author	Rodgers, KJ
dc.contributor.author	Mitrovic, SM
dc.contributor.author	Bishop, DP
dc.date.accessioned	2022-12-06T03:44:38Z
dc.date.available	2022-10-26
dc.date.available	2022-12-06T03:44:38Z
dc.date.issued	2022-10-30
dc.identifier.citation	Molecules, 2022, 27, (21), pp. 1-11
dc.identifier.issn	1420-3049
dc.identifier.issn	1420-3049
dc.identifier.uri	http://hdl.handle.net/10453/164151
dc.description.abstract	β-N-methylamino L-alanine (BMAA) is a neurotoxin linked to high incidences of neurodegenerative disease. The toxin, along with two of its common isomers, 2,4-diaminobuytric acid (2,4-DAB) and N-(2-aminoethyl)glycine (AEG), is produced by multiple genera of cyanobacteria worldwide. Whilst there are many reports of locations and species of cyanobacteria associated with the production of BMAA during a bloom, there is a lack of information tracking changes in concentration across a single bloom event. This study aimed to measure the concentrations of BMAA and its isomers through the progression and end of a cyanobacteria bloom event using liquid chromatography-triple quadrupole-mass spectrometry. BMAA was detected in all samples analysed, with a decreasing trend observed as the bloom progressed. BMAA's isomers were also detected in all samples, however, they did not follow the same decreasing pattern. This study highlights the potential for current sampling protocols that measure a single time point as representative of a bloom's overall toxin content to underestimate BMAA concentration during a bloom event.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI AG
dc.relation.ispartof	Molecules
dc.relation.isbasedon	10.3390/molecules27217382
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry, 0307 Theoretical and Computational Chemistry
dc.subject.classification	Organic Chemistry
dc.subject.mesh	Amino Acids, Diamino
dc.subject.mesh	Chromatography, Liquid
dc.subject.mesh	Cyanobacteria
dc.subject.mesh	Humans
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Humans
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Amino Acids, Diamino
dc.subject.mesh	Cyanobacteria
dc.subject.mesh	Chromatography, Liquid
dc.subject.mesh	Humans
dc.subject.mesh	Cyanobacteria
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Amino Acids, Diamino
dc.subject.mesh	Chromatography, Liquid
dc.title	The Changes in Cyanobacterial Concentration of β-Methylamino-L-Alanine during a Bloom Event.
dc.type	Journal Article
utslib.citation.volume	27
utslib.location.activity	Switzerland
utslib.for	0304 Medicinal and Biomolecular Chemistry
utslib.for	0305 Organic Chemistry
utslib.for	0307 Theoretical and Computational Chemistry
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-12-06T03:44:36Z
pubs.issue	21
pubs.publication-status	Published
pubs.volume	27
utslib.citation.issue	21

Abstract:

β-N-methylamino L-alanine (BMAA) is a neurotoxin linked to high incidences of neurodegenerative disease. The toxin, along with two of its common isomers, 2,4-diaminobuytric acid (2,4-DAB) and N-(2-aminoethyl)glycine (AEG), is produced by multiple genera of cyanobacteria worldwide. Whilst there are many reports of locations and species of cyanobacteria associated with the production of BMAA during a bloom, there is a lack of information tracking changes in concentration across a single bloom event. This study aimed to measure the concentrations of BMAA and its isomers through the progression and end of a cyanobacteria bloom event using liquid chromatography-triple quadrupole-mass spectrometry. BMAA was detected in all samples analysed, with a decreasing trend observed as the bloom progressed. BMAA's isomers were also detected in all samples, however, they did not follow the same decreasing pattern. This study highlights the potential for current sampling protocols that measure a single time point as representative of a bloom's overall toxin content to underestimate BMAA concentration during a bloom event.

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http://hdl.handle.net/10453/164151