Bioactive Compounds from the Plants of the Elaeodendron Genus and Their Biological Activities—A Review

Jennifer, N; Mishra, AP; Nigam, M; Devkota, HP; Paudel, KR; Matsabisa, MG

Bioactive Compounds from the Plants of the Elaeodendron Genus and Their Biological Activities—A Review

Jennifer, N Mishra, AP Nigam, M Devkota, HP Paudel, KR Matsabisa, MG

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Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: Applied Sciences, 12, (24), pp. 12618-12618

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Field	Value	Language
dc.contributor.author	Jennifer, N
dc.contributor.author	Mishra, AP
dc.contributor.author	Nigam, M
dc.contributor.author	Devkota, HP
dc.contributor.author	Paudel, KR
dc.contributor.author	Matsabisa, MG
dc.date.accessioned	2022-12-09T12:35:49Z
dc.date.available	2022-12-09T12:35:49Z
dc.identifier.citation	Applied Sciences, 12, (24), pp. 12618-12618
dc.identifier.issn	2076-3417
dc.identifier.uri	http://hdl.handle.net/10453/164274
dc.description.abstract	<jats:p>Elaeodendron is a genus of tiny trees, shrubs, vines, and herbs consisting of about 23 species. It is used in traditional medicine and has a wide range of pharmacological activities. From the plants in this genus, flavonoids, terpenoids, cardiac glycosides, and cardenolides have been isolated. Elaeodendron species have been the subject of numerous in vitro investigations; however, not many vivo studies are available. Preclinical investigations have also revealed antiviral, anti-HIV, anticancer, antiproliferative, antioxidant, antifungal, anti-inflammation, cytotoxic, anti-plasmodial, anti-arthritic, antibacterial, and anti-diabetic activities. Bioactive substances found in Elaedendron that function in a variety of ways are related to these biological processes. Several databases, including PubMed, Scopus, etc., were searched using keywords such as “Elaeodendron”, “chemical constituents”, “anti-cancer”, “anti-viral”, “pharmacology”, etc., to perform a comprehensive review of the current literature. In this sense, this review intends to provide the most recent developments in the ethnomedical use of Elaeodendron species, and their therapeutic benefits and bioactive compounds. Many species of this genus are reported to be toxic. To provide stronger scientific support for their conventional usage, more in vivo and clinical research for mechanism-based pharmacological evaluation as well as toxicological studies should be carried out in the future.</jats:p>
dc.language	en
dc.publisher	MDPI AG
dc.relation.ispartof	Applied Sciences
dc.relation.isbasedon	10.3390/app122412618
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Bioactive Compounds from the Plants of the Elaeodendron Genus and Their Biological Activities—A Review
dc.type	Journal Article
utslib.citation.volume	12
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CFI - Centre for Inflammation
utslib.copyright.status	open_access	*
dc.date.updated	2022-12-09T12:35:47Z
pubs.issue	24
pubs.publication-status	Published online
pubs.volume	12
utslib.citation.issue	24

Abstract:

Elaeodendron is a genus of tiny trees, shrubs, vines, and herbs consisting of about 23 species. It is used in traditional medicine and has a wide range of pharmacological activities. From the plants in this genus, flavonoids, terpenoids, cardiac glycosides, and cardenolides have been isolated. Elaeodendron species have been the subject of numerous in vitro investigations; however, not many vivo studies are available. Preclinical investigations have also revealed antiviral, anti-HIV, anticancer, antiproliferative, antioxidant, antifungal, anti-inflammation, cytotoxic, anti-plasmodial, anti-arthritic, antibacterial, and anti-diabetic activities. Bioactive substances found in Elaedendron that function in a variety of ways are related to these biological processes. Several databases, including PubMed, Scopus, etc., were searched using keywords such as “Elaeodendron”, “chemical constituents”, “anti-cancer”, “anti-viral”, “pharmacology”, etc., to perform a comprehensive review of the current literature. In this sense, this review intends to provide the most recent developments in the ethnomedical use of Elaeodendron species, and their therapeutic benefits and bioactive compounds. Many species of this genus are reported to be toxic. To provide stronger scientific support for their conventional usage, more in vivo and clinical research for mechanism-based pharmacological evaluation as well as toxicological studies should be carried out in the future.

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http://hdl.handle.net/10453/164274