Influence of Circadian Clocks on Optimal Regime of Central C-N Metabolism of Cyanobacteria

Červený, J; Šalagoviĉ, J; Muzika, F; Šafránek, D; Schreiber, I

Influence of Circadian Clocks on Optimal Regime of Central C-N Metabolism of Cyanobacteria

Červený, J Šalagoviĉ, J Muzika, F Šafránek, D Schreiber, I

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Publisher:: Elsevier
Publication Type:: Chapter
Citation:: Cyanobacteria: From Basic Science to Applications, 2018, pp. 193-206
Issue Date:: 2018-12-03

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Field	Value	Language
dc.contributor.author	Červený, J
dc.contributor.author	Šalagoviĉ, J
dc.contributor.author	Muzika, F
dc.contributor.author	Šafránek, D
dc.contributor.author	Schreiber, I
dc.date.accessioned	2022-12-22T21:13:48Z
dc.date.available	2022-12-22T21:13:48Z
dc.date.issued	2018-12-03
dc.identifier.citation	Cyanobacteria: From Basic Science to Applications, 2018, pp. 193-206
dc.identifier.isbn	9780128146675
dc.identifier.uri	http://hdl.handle.net/10453/164524
dc.description.abstract	Mechanistic aspects of cyanobacteria clock and metabolism have been analyzed in considerable detail during recent decades, but only limited knowledge is available about particular link(s) between the clock and controlled metabolic processes. This chapter describes a case study in which a mechanistic model of a circadian oscillator is coupled with a model of central carbonrnitrogen metabolism and formal methods based on temporal logic and bifurcation analysis are applied to examine the response of the metabolic part of the combined model to autonomous clock oscillations. The analysis identifies a set of parametric groups that, when applied to the in silico system, lead either to an optimal configuration of metabolic pathways for most efficient rhythmic function of the metabolism or to (oscillatory) system death. Under controlled conditions in monitored environments, such as cultivation in photobioreactors, the knowledge can be used for optimal regulation of production capacity that would reflect dynamic constraints of real-world systems.
dc.language	en
dc.publisher	Elsevier
dc.relation.ispartof	Cyanobacteria: From Basic Science to Applications
dc.relation.isbasedon	10.1016/B978-0-12-814667-5.00009-X
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	Influence of Circadian Clocks on Optimal Regime of Central C-N Metabolism of Cyanobacteria
dc.type	Chapter
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	closed_access	*
dc.date.updated	2022-12-22T21:13:47Z
pubs.publication-status	Published

Abstract:

Mechanistic aspects of cyanobacteria clock and metabolism have been analyzed in considerable detail during recent decades, but only limited knowledge is available about particular link(s) between the clock and controlled metabolic processes. This chapter describes a case study in which a mechanistic model of a circadian oscillator is coupled with a model of central carbonrnitrogen metabolism and formal methods based on temporal logic and bifurcation analysis are applied to examine the response of the metabolic part of the combined model to autonomous clock oscillations. The analysis identifies a set of parametric groups that, when applied to the in silico system, lead either to an optimal configuration of metabolic pathways for most efficient rhythmic function of the metabolism or to (oscillatory) system death. Under controlled conditions in monitored environments, such as cultivation in photobioreactors, the knowledge can be used for optimal regulation of production capacity that would reflect dynamic constraints of real-world systems.

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http://hdl.handle.net/10453/164524