Role of Suppressor of cytokine signaling 2 during the development and resolution of an experimental arthritis.

Cramer, A; Galvão, I; Venturini de Sá, N; Gaio, P; Fernanda de Melo Oliveira, N; Rates Gonzaga Santos, M; Henrique Campolina-Silva, G; Vinicius Santos Valiate, B; Rezende Souza, F; Dantas Cassali, G; Martins Teixeira, M; Almeida Amaral, F; Simão Machado, F

Role of Suppressor of cytokine signaling 2 during the development and resolution of an experimental arthritis.

Cramer, A Galvão, I Venturini de Sá, N Gaio, P Fernanda de Melo Oliveira, N Rates Gonzaga Santos, M Henrique Campolina-Silva, G Vinicius Santos Valiate, B Rezende Souza, F Dantas Cassali, G Martins Teixeira, M Almeida Amaral, F Simão Machado, F

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Publisher:: ACADEMIC PRESS INC ELSEVIER SCIENCE
Publication Type:: Journal Article
Citation:: Cell Immunol, 2022, 372, pp. 104476
Issue Date:: 2022-02

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Field	Value	Language
dc.contributor.author	Cramer, A
dc.contributor.author	Galvão, I
dc.contributor.author	Venturini de Sá, N
dc.contributor.author	Gaio, P
dc.contributor.author	Fernanda de Melo Oliveira, N
dc.contributor.author	Rates Gonzaga Santos, M
dc.contributor.author	Henrique Campolina-Silva, G
dc.contributor.author	Vinicius Santos Valiate, B
dc.contributor.author	Rezende Souza, F
dc.contributor.author	Dantas Cassali, G
dc.contributor.author	Martins Teixeira, M
dc.contributor.author	Almeida Amaral, F
dc.contributor.author	Simão Machado, F
dc.date.accessioned	2023-02-06T03:29:44Z
dc.date.available	2021-12-31
dc.date.available	2023-02-06T03:29:44Z
dc.date.issued	2022-02
dc.identifier.citation	Cell Immunol, 2022, 372, pp. 104476
dc.identifier.issn	0008-8749
dc.identifier.issn	1090-2163
dc.identifier.uri	http://hdl.handle.net/10453/165935
dc.description.abstract	Rheumatoid arthritis(RA) is a debilitating chronic inflammatory disease. Suppressors of Cytokine Signaling(SOCS) proteins regulate homeostasis and pathogenesis in several diseases. The intersection between RA pathophysiology and SOCS2 is unclear. Herein, we investigated the roles of SOCS2 during the development of an experimental antigen-induced arthritis(AIA). In wild type mice, joint SOCS2 expression was reduced during AIA development. At the peak of inflammation, SOCS2-/- mice presented with reduced numbers of infiltrated cells in their joints. At the late phase of AIA, however, exhibited increased adhesion/infiltration of neutrophils, macrophages, CD4+-T cells, CD4+CD8+-T cells, and CD4-CD8--T cells associated with elevated IL-17 and IFN-γ levels, joint damage, proteoglycan loss, and nociception. SOCS2 deficiency resulted in lower numbers of apoptotic neutrophils and reduced efferocytosis. The present study demonstrated the vital role of SOCS2 during the development and resolution of an experimental RA model. Hence, this protein may be a novel therapeutic target for this disorder.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartof	Cell Immunol
dc.relation.isbasedon	10.1016/j.cellimm.2021.104476
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1107 Immunology
dc.subject.classification	Immunology
dc.subject.mesh	Adaptive Immunity
dc.subject.mesh	Animals
dc.subject.mesh	Arthritis, Experimental
dc.subject.mesh	Cell Adhesion
dc.subject.mesh	Disease Progression
dc.subject.mesh	Endocytosis
dc.subject.mesh	Immunity, Innate
dc.subject.mesh	Leukocytes
dc.subject.mesh	Macrophages
dc.subject.mesh	Male
dc.subject.mesh	Mice
dc.subject.mesh	Mice, Inbred C57BL
dc.subject.mesh	Mice, Knockout
dc.subject.mesh	Spleen
dc.subject.mesh	Suppressor of Cytokine Signaling Proteins
dc.subject.mesh	Spleen
dc.subject.mesh	Leukocytes
dc.subject.mesh	Macrophages
dc.subject.mesh	Animals
dc.subject.mesh	Mice, Inbred C57BL
dc.subject.mesh	Mice, Knockout
dc.subject.mesh	Mice
dc.subject.mesh	Arthritis, Experimental
dc.subject.mesh	Disease Progression
dc.subject.mesh	Cell Adhesion
dc.subject.mesh	Endocytosis
dc.subject.mesh	Male
dc.subject.mesh	Suppressor of Cytokine Signaling Proteins
dc.subject.mesh	Immunity, Innate
dc.subject.mesh	Adaptive Immunity
dc.title	Role of Suppressor of cytokine signaling 2 during the development and resolution of an experimental arthritis.
dc.type	Journal Article
utslib.citation.volume	372
utslib.location.activity	Netherlands
utslib.for	1107 Immunology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2023-02-06T03:29:42Z
pubs.publication-status	Published
pubs.volume	372

Abstract:

Rheumatoid arthritis(RA) is a debilitating chronic inflammatory disease. Suppressors of Cytokine Signaling(SOCS) proteins regulate homeostasis and pathogenesis in several diseases. The intersection between RA pathophysiology and SOCS2 is unclear. Herein, we investigated the roles of SOCS2 during the development of an experimental antigen-induced arthritis(AIA). In wild type mice, joint SOCS2 expression was reduced during AIA development. At the peak of inflammation, SOCS2-/- mice presented with reduced numbers of infiltrated cells in their joints. At the late phase of AIA, however, exhibited increased adhesion/infiltration of neutrophils, macrophages, CD4+-T cells, CD4+CD8+-T cells, and CD4-CD8--T cells associated with elevated IL-17 and IFN-γ levels, joint damage, proteoglycan loss, and nociception. SOCS2 deficiency resulted in lower numbers of apoptotic neutrophils and reduced efferocytosis. The present study demonstrated the vital role of SOCS2 during the development and resolution of an experimental RA model. Hence, this protein may be a novel therapeutic target for this disorder.

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http://hdl.handle.net/10453/165935