Common anti-haemostatic medications increase the severity of systemic infection by uropathogenic Escherichia coli.

Tran, VLT; Hortle, E; Britton, WJ; Oehlers, SH

Common anti-haemostatic medications increase the severity of systemic infection by uropathogenic Escherichia coli.

Tran, VLT Hortle, E

Britton, WJ Oehlers, SH

Permalink

Publisher:: ELSEVIER GMBH
Publication Type:: Journal Article
Citation:: Microbiol Res, 2022, 254, pp. 126918
Issue Date:: 2022-01

Closed Access

	Filename	Description	Size
	1-s2.0-S094450132100224X-main.pdf		2 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Tran, VLT
dc.contributor.author	Hortle, E https://orcid.org/0000-0001-9633-5638
dc.contributor.author	Britton, WJ
dc.contributor.author	Oehlers, SH
dc.date.accessioned	2023-02-07T05:13:51Z
dc.date.available	2021-11-10
dc.date.available	2023-02-07T05:13:51Z
dc.date.issued	2022-01
dc.identifier.citation	Microbiol Res, 2022, 254, pp. 126918
dc.identifier.issn	0944-5013
dc.identifier.issn	1618-0623
dc.identifier.uri	http://hdl.handle.net/10453/165970
dc.description.abstract	Uropathogenic Escherichia coli (UPEC) causes urinary tract infections that can result in sepsis. The haemostatic system is protective in the pyelonephritis stage of ascending UPEC infection, but the role of the haemostatic system has not been investigated during sepsis. Here we utilize a zebrafish-UPEC systemic infection model to visualize infection-induced coagulation and examine the effects of commonly prescribed anti-haemostatic medications on the infection severity. Treatment of systemically infected zebrafish with warfarin, aspirin, or ticagrelor reduced host survival, while stabilization of clots with aminocaproic acid increased host survival. Anti-haemostatic drug treatment increased UPEC burden. Our findings provide evidence that commonly prescribed anti-haemostatic medications may worsen the outcome of severe UPEC infection.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER GMBH
dc.relation.ispartof	Microbiol Res
dc.relation.isbasedon	10.1016/j.micres.2021.126918
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0605 Microbiology, 1108 Medical Microbiology
dc.subject.classification	Microbiology
dc.subject.mesh	Animals
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Escherichia coli Infections
dc.subject.mesh	Hemostatics
dc.subject.mesh	Sepsis
dc.subject.mesh	Severity of Illness Index
dc.subject.mesh	Urinary Tract Infections
dc.subject.mesh	Uropathogenic Escherichia coli
dc.subject.mesh	Zebrafish
dc.subject.mesh	Animals
dc.subject.mesh	Zebrafish
dc.subject.mesh	Escherichia coli Infections
dc.subject.mesh	Sepsis
dc.subject.mesh	Urinary Tract Infections
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Hemostatics
dc.subject.mesh	Severity of Illness Index
dc.subject.mesh	Uropathogenic Escherichia coli
dc.subject.mesh	Animals
dc.subject.mesh	Disease Models, Animal
dc.subject.mesh	Escherichia coli Infections
dc.subject.mesh	Hemostatics
dc.subject.mesh	Sepsis
dc.subject.mesh	Severity of Illness Index
dc.subject.mesh	Urinary Tract Infections
dc.subject.mesh	Uropathogenic Escherichia coli
dc.subject.mesh	Zebrafish
dc.title	Common anti-haemostatic medications increase the severity of systemic infection by uropathogenic Escherichia coli.
dc.type	Journal Article
utslib.citation.volume	254
utslib.location.activity	Germany
utslib.for	0605 Microbiology
utslib.for	1108 Medical Microbiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFI - Centre for Inflammation
utslib.copyright.status	closed_access	*
dc.date.updated	2023-02-07T05:13:49Z
pubs.publication-status	Published
pubs.volume	254

Abstract:

Uropathogenic Escherichia coli (UPEC) causes urinary tract infections that can result in sepsis. The haemostatic system is protective in the pyelonephritis stage of ascending UPEC infection, but the role of the haemostatic system has not been investigated during sepsis. Here we utilize a zebrafish-UPEC systemic infection model to visualize infection-induced coagulation and examine the effects of commonly prescribed anti-haemostatic medications on the infection severity. Treatment of systemically infected zebrafish with warfarin, aspirin, or ticagrelor reduced host survival, while stabilization of clots with aminocaproic acid increased host survival. Anti-haemostatic drug treatment increased UPEC burden. Our findings provide evidence that commonly prescribed anti-haemostatic medications may worsen the outcome of severe UPEC infection.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/165970