Crown ether-thiourea conjugates as ion transporters

Zhao, Z; Tang, B; Yan, X; Wu, X; Li, Z; Gale, PA; Jiang, YB

Crown ether-thiourea conjugates as ion transporters

Zhao, Z Tang, B Yan, X Wu, X Li, Z Gale, PA Jiang, YB

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Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: Frontiers of Chemical Science and Engineering, 2022, 16, (1), pp. 81-91
Issue Date:: 2022-01-01

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Field	Value	Language
dc.contributor.author	Zhao, Z
dc.contributor.author	Tang, B
dc.contributor.author	Yan, X
dc.contributor.author	Wu, X
dc.contributor.author	Li, Z
dc.contributor.author	Gale, PA
dc.contributor.author	Jiang, YB
dc.date.accessioned	2023-02-07T23:43:08Z
dc.date.available	2023-02-07T23:43:08Z
dc.date.issued	2022-01-01
dc.identifier.citation	Frontiers of Chemical Science and Engineering, 2022, 16, (1), pp. 81-91
dc.identifier.issn	2095-0179
dc.identifier.issn	2095-0187
dc.identifier.uri	http://hdl.handle.net/10453/165979
dc.description.abstract	Na+, Cl− and K+ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both Na+ and Cl− across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of K+ ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for K+ ions, which led to predominant partitioning of the transporters as the K+ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with Na+, Cl− and K+ transport capabilities may have potential biological and medicinal applications. [Figure not available: see fulltext.]
dc.language	en
dc.publisher	Springer Nature
dc.relation.ispartof	Frontiers of Chemical Science and Engineering
dc.relation.isbasedon	10.1007/s11705-021-2049-7
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0904 Chemical Engineering
dc.title	Crown ether-thiourea conjugates as ion transporters
dc.type	Journal Article
utslib.citation.volume	16
utslib.for	0904 Chemical Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	closed_access	*
dc.date.updated	2023-02-07T23:43:06Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	16
utslib.citation.issue	1

Abstract:

Na+, Cl− and K+ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both Na+ and Cl− across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of K+ ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for K+ ions, which led to predominant partitioning of the transporters as the K+ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with Na+, Cl− and K+ transport capabilities may have potential biological and medicinal applications. [Figure not available: see fulltext.]

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