The Auditory Afferent Pathway as a Clinical Marker of Alzheimer's Disease.

Shad, KF; Soubra, W; Cordato, DJ

The Auditory Afferent Pathway as a Clinical Marker of Alzheimer's Disease.

Shad, KF Soubra, W Cordato, DJ

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Publisher:: IOS Press
Publication Type:: Journal Article
Citation:: J Alzheimers Dis, 2022, 85, (1), pp. 47-53
Issue Date:: 2022

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Field	Value	Language
dc.contributor.author	Shad, KF
dc.contributor.author	Soubra, W
dc.contributor.author	Cordato, DJ
dc.date.accessioned	2023-02-14T23:52:30Z
dc.date.available	2023-02-14T23:52:30Z
dc.date.issued	2022
dc.identifier.citation	J Alzheimers Dis, 2022, 85, (1), pp. 47-53
dc.identifier.issn	1387-2877
dc.identifier.issn	1875-8908
dc.identifier.uri	http://hdl.handle.net/10453/166122
dc.description.abstract	Brain stem neural tracts and nuclei may be disturbed prior to observable neuronal atrophy in AD. In this perspective, we discuss the notion of functional deficits presenting prior to structural abnormalities in Alzheimer's disease (AD). Imaging of inferior colliculi using magnetic resonance spectroscopy (MRS) shows significant decrease in the neuronal markers, N acetyl aspartate/creatine ratio and increase in the glial marker myo-Inositol, in subjects with Mini-Mental State Examination scores greater than 24 and with no signs of atrophy in their MRI of the medial temporal lobe. Abnormalities in components of the auditory event-related potentials (ERPs) are described in cognitive impairment including AD. We observed a significant decrease in amplitude and increase in latency during the first 10 ms of auditory evoked potentials measured on electroencephalography (EEG) indicating slow auditory response of the brainstem. EEG spectral power recorded at the cortex is also associated with neural activity at the level of the inferior colliculi. We postulate that a functional examination of auditory afferent pathways, using non-invasive techniques, such as MRS, brain stem auditory evoked potentials (BAEPs) and ERPs may improve diagnostic accuracy of AD. Functional changes precede structural changes and it is important to further understand the relationship between biochemical and electrophysiological measures such as MRS, BAEPs and EEG.
dc.format	Print
dc.language	eng
dc.publisher	IOS Press
dc.relation.ispartof	J Alzheimers Dis
dc.relation.isbasedon	10.3233/JAD-215206
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences, 1109 Neurosciences, 1702 Cognitive Sciences
dc.subject.classification	Neurology & Neurosurgery
dc.subject.mesh	Acoustic Stimulation
dc.subject.mesh	Afferent Pathways
dc.subject.mesh	Aged
dc.subject.mesh	Alzheimer Disease
dc.subject.mesh	Aspartic Acid
dc.subject.mesh	Biomarkers
dc.subject.mesh	Cerebral Cortex
dc.subject.mesh	Cognitive Dysfunction
dc.subject.mesh	Creatine
dc.subject.mesh	Electroencephalography
dc.subject.mesh	Evoked Potentials, Auditory
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Inositol
dc.subject.mesh	Magnetic Resonance Imaging
dc.subject.mesh	Magnetic Resonance Spectroscopy
dc.subject.mesh	Male
dc.subject.mesh	Mental Status and Dementia Tests
dc.subject.mesh	Middle Aged
dc.subject.mesh	Temporal Lobe
dc.subject.mesh	Cerebral Cortex
dc.subject.mesh	Temporal Lobe
dc.subject.mesh	Afferent Pathways
dc.subject.mesh	Humans
dc.subject.mesh	Alzheimer Disease
dc.subject.mesh	Inositol
dc.subject.mesh	Creatine
dc.subject.mesh	Aspartic Acid
dc.subject.mesh	Magnetic Resonance Imaging
dc.subject.mesh	Electroencephalography
dc.subject.mesh	Acoustic Stimulation
dc.subject.mesh	Magnetic Resonance Spectroscopy
dc.subject.mesh	Evoked Potentials, Auditory
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Biomarkers
dc.subject.mesh	Cognitive Dysfunction
dc.subject.mesh	Mental Status and Dementia Tests
dc.title	The Auditory Afferent Pathway as a Clinical Marker of Alzheimer's Disease.
dc.type	Journal Article
utslib.citation.volume	85
utslib.location.activity	Netherlands
utslib.for	1103 Clinical Sciences
utslib.for	1109 Neurosciences
utslib.for	1702 Cognitive Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	closed_access	*
dc.date.updated	2023-02-14T23:52:28Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	85
utslib.citation.issue	1

Abstract:

Brain stem neural tracts and nuclei may be disturbed prior to observable neuronal atrophy in AD. In this perspective, we discuss the notion of functional deficits presenting prior to structural abnormalities in Alzheimer's disease (AD). Imaging of inferior colliculi using magnetic resonance spectroscopy (MRS) shows significant decrease in the neuronal markers, N acetyl aspartate/creatine ratio and increase in the glial marker myo-Inositol, in subjects with Mini-Mental State Examination scores greater than 24 and with no signs of atrophy in their MRI of the medial temporal lobe. Abnormalities in components of the auditory event-related potentials (ERPs) are described in cognitive impairment including AD. We observed a significant decrease in amplitude and increase in latency during the first 10 ms of auditory evoked potentials measured on electroencephalography (EEG) indicating slow auditory response of the brainstem. EEG spectral power recorded at the cortex is also associated with neural activity at the level of the inferior colliculi. We postulate that a functional examination of auditory afferent pathways, using non-invasive techniques, such as MRS, brain stem auditory evoked potentials (BAEPs) and ERPs may improve diagnostic accuracy of AD. Functional changes precede structural changes and it is important to further understand the relationship between biochemical and electrophysiological measures such as MRS, BAEPs and EEG.

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http://hdl.handle.net/10453/166122