Ergosterol isolated from cloud ear mushroom (Auricularia polytricha) attenuates bisphenol A-induced BV2 microglial cell inflammation.

Sillapachaiyaporn, C; Chuchawankul, S; Nilkhet, S; Moungkote, N; Sarachana, T; Ung, AT; Baek, SJ; Tencomnao, T

Ergosterol isolated from cloud ear mushroom (Auricularia polytricha) attenuates bisphenol A-induced BV2 microglial cell inflammation.

Sillapachaiyaporn, C Chuchawankul, S Nilkhet, S Moungkote, N Sarachana, T Ung, AT Baek, SJ Tencomnao, T

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Food Res Int, 2022, 157, pp. 111433
Issue Date:: 2022-07

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Field	Value	Language
dc.contributor.author	Sillapachaiyaporn, C
dc.contributor.author	Chuchawankul, S
dc.contributor.author	Nilkhet, S
dc.contributor.author	Moungkote, N
dc.contributor.author	Sarachana, T
dc.contributor.author	Ung, AT
dc.contributor.author	Baek, SJ
dc.contributor.author	Tencomnao, T
dc.date.accessioned	2023-02-15T03:30:31Z
dc.date.available	2022-05-25
dc.date.available	2023-02-15T03:30:31Z
dc.date.issued	2022-07
dc.identifier.citation	Food Res Int, 2022, 157, pp. 111433
dc.identifier.issn	0963-9969
dc.identifier.issn	1873-7145
dc.identifier.uri	http://hdl.handle.net/10453/166139
dc.description.abstract	Bisphenol A (BPA) has been reported to have neurotoxic properties that may increase the risk of neurodegenerative diseases by inducing neuroinflammation. Auricularia polytricha (AP) is an edible mushroom with several medicinal properties. Herein, the anti-neuroinflammatory effects of AP extracts against BPA-induced inflammation of BV2 microglial cells were investigated. Hexane (APH) and ethanol (APE) extracts of AP inhibited BPA-induced neuroinflammation in BV2 microglia by reducing microglial activation and the expression of pro-inflammatory cytokines. These anti-inflammatory effects were regulated by the NF-κB signaling pathway. In addition, APH and APE exhibited antioxidative effects by increasing the activity of the SOD-1 enzyme and restoring the accumulation of reactive oxygen species (ROS) in BPA-induced BV2 cells. Moreover, the conditioned medium prepared using BPA-induced BV2 cells demonstrated that the presence of APH or APE could attenuate ROS production in HT-22 cells. Further, ergosterol was isolated from APE and also showed anti-inflammatory and antioxidative activities. In conclusion, AP extracts and ergosterol attenuated neuroinflammation against BPA induction in BV2 microglial cells through the NF-κB signaling pathway.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Food Res Int
dc.relation.isbasedon	10.1016/j.foodres.2022.111433
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0904 Chemical Engineering, 0908 Food Sciences, 1111 Nutrition and Dietetics
dc.subject.classification	Food Science
dc.subject.mesh	Agaricales
dc.subject.mesh	Anti-Inflammatory Agents
dc.subject.mesh	Auricularia
dc.subject.mesh	Benzhydryl Compounds
dc.subject.mesh	Ergosterol
dc.subject.mesh	Inflammation
dc.subject.mesh	Microglia
dc.subject.mesh	NF-kappa B
dc.subject.mesh	Phenols
dc.subject.mesh	Reactive Oxygen Species
dc.subject.mesh	Microglia
dc.subject.mesh	Agaricales
dc.subject.mesh	Inflammation
dc.subject.mesh	Reactive Oxygen Species
dc.subject.mesh	Benzhydryl Compounds
dc.subject.mesh	Phenols
dc.subject.mesh	Ergosterol
dc.subject.mesh	NF-kappa B
dc.subject.mesh	Anti-Inflammatory Agents
dc.subject.mesh	Auricularia
dc.title	Ergosterol isolated from cloud ear mushroom (Auricularia polytricha) attenuates bisphenol A-induced BV2 microglial cell inflammation.
dc.type	Journal Article
utslib.citation.volume	157
utslib.location.activity	Canada
utslib.for	0904 Chemical Engineering
utslib.for	0908 Food Sciences
utslib.for	1111 Nutrition and Dietetics
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2023-02-15T03:30:29Z
pubs.publication-status	Published
pubs.volume	157

Abstract:

Bisphenol A (BPA) has been reported to have neurotoxic properties that may increase the risk of neurodegenerative diseases by inducing neuroinflammation. Auricularia polytricha (AP) is an edible mushroom with several medicinal properties. Herein, the anti-neuroinflammatory effects of AP extracts against BPA-induced inflammation of BV2 microglial cells were investigated. Hexane (APH) and ethanol (APE) extracts of AP inhibited BPA-induced neuroinflammation in BV2 microglia by reducing microglial activation and the expression of pro-inflammatory cytokines. These anti-inflammatory effects were regulated by the NF-κB signaling pathway. In addition, APH and APE exhibited antioxidative effects by increasing the activity of the SOD-1 enzyme and restoring the accumulation of reactive oxygen species (ROS) in BPA-induced BV2 cells. Moreover, the conditioned medium prepared using BPA-induced BV2 cells demonstrated that the presence of APH or APE could attenuate ROS production in HT-22 cells. Further, ergosterol was isolated from APE and also showed anti-inflammatory and antioxidative activities. In conclusion, AP extracts and ergosterol attenuated neuroinflammation against BPA induction in BV2 microglial cells through the NF-κB signaling pathway.

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http://hdl.handle.net/10453/166139