Facets of ICP-MS and their potential in the medical sciences-Part 2: nanomedicine, immunochemistry, mass cytometry, and bioassays.

Clases, D; Gonzalez de Vega, R

Facets of ICP-MS and their potential in the medical sciences-Part 2: nanomedicine, immunochemistry, mass cytometry, and bioassays.

Clases, D Gonzalez de Vega, R

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Publisher:: SPRINGER HEIDELBERG
Publication Type:: Journal Article
Citation:: Anal Bioanal Chem, 2022, 414, (25), pp. 7363-7386
Issue Date:: 2022-10

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Field	Value	Language
dc.contributor.author	Clases, D
dc.contributor.author	Gonzalez de Vega, R https://orcid.org/0000-0002-9806-9633
dc.date.accessioned	2023-02-15T04:14:46Z
dc.date.available	2022-07-29
dc.date.available	2023-02-15T04:14:46Z
dc.date.issued	2022-10
dc.identifier.citation	Anal Bioanal Chem, 2022, 414, (25), pp. 7363-7386
dc.identifier.issn	1618-2642
dc.identifier.issn	1618-2650
dc.identifier.uri	http://hdl.handle.net/10453/166143
dc.description.abstract	Inductively coupled-plasma mass spectrometry (ICP-MS) has transformed our knowledge on the role of trace and major elements in biology and has emerged as the most versatile technique in elemental mass spectrometry. The scope of ICP-MS has dramatically changed since its inception, and nowadays, it is a mature platform technology that is compatible with chromatographic and laser ablation (LA) systems. Over the last decades, it kept pace with various technological advances and was inspired by interdisciplinary approaches which endorsed new areas of applications. While the first part of this review was dedicated to fundamentals in ICP-MS, its hyphenated techniques and the application in biomonitoring, isotope ratio analysis, elemental speciation analysis, and elemental bioimaging, this second part will introduce relatively current directions in ICP-MS and their potential to provide novel perspectives in the medical sciences. In this context, current directions for the characterisation of novel nanomaterials which are considered for biomedical applications like drug delivery and imaging platforms will be discussed while considering different facets of ICP-MS including single event analysis and dedicated hyphenated techniques. Subsequently, immunochemistry techniques will be reviewed in their capability to expand the scope of ICP-MS enabling analysis of a large range of biomolecules alongside elements. These methods inspired mass cytometry and imaging mass cytometry and have the potential to transform diagnostics and treatment by offering new paradigms for personalised medicine. Finally, the interlacing of immunochemistry methods, single event analysis, and functional nanomaterials has opened new horizons to design novel bioassays which promise potential as assets for clinical applications and larger screening programs and will be discussed in their capabilities to detect low-level proteins and nucleic acids.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	SPRINGER HEIDELBERG
dc.relation.ispartof	Anal Bioanal Chem
dc.relation.isbasedon	10.1007/s00216-022-04260-8
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	03 Chemical Sciences, 06 Biological Sciences, 09 Engineering
dc.subject.classification	Analytical Chemistry
dc.subject.mesh	Biological Assay
dc.subject.mesh	Immunochemistry
dc.subject.mesh	Isotopes
dc.subject.mesh	Nanomedicine
dc.subject.mesh	Nucleic Acids
dc.subject.mesh	Isotopes
dc.subject.mesh	Nucleic Acids
dc.subject.mesh	Biological Assay
dc.subject.mesh	Immunochemistry
dc.subject.mesh	Nanomedicine
dc.subject.mesh	Biological Assay
dc.subject.mesh	Immunochemistry
dc.subject.mesh	Isotopes
dc.subject.mesh	Nanomedicine
dc.subject.mesh	Nucleic Acids
dc.title	Facets of ICP-MS and their potential in the medical sciences-Part 2: nanomedicine, immunochemistry, mass cytometry, and bioassays.
dc.type	Journal Article
utslib.citation.volume	414
utslib.location.activity	Germany
utslib.for	03 Chemical Sciences
utslib.for	06 Biological Sciences
utslib.for	09 Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2023-02-15T04:14:40Z
pubs.issue	25
pubs.publication-status	Published
pubs.volume	414
utslib.citation.issue	25

Abstract:

Inductively coupled-plasma mass spectrometry (ICP-MS) has transformed our knowledge on the role of trace and major elements in biology and has emerged as the most versatile technique in elemental mass spectrometry. The scope of ICP-MS has dramatically changed since its inception, and nowadays, it is a mature platform technology that is compatible with chromatographic and laser ablation (LA) systems. Over the last decades, it kept pace with various technological advances and was inspired by interdisciplinary approaches which endorsed new areas of applications. While the first part of this review was dedicated to fundamentals in ICP-MS, its hyphenated techniques and the application in biomonitoring, isotope ratio analysis, elemental speciation analysis, and elemental bioimaging, this second part will introduce relatively current directions in ICP-MS and their potential to provide novel perspectives in the medical sciences. In this context, current directions for the characterisation of novel nanomaterials which are considered for biomedical applications like drug delivery and imaging platforms will be discussed while considering different facets of ICP-MS including single event analysis and dedicated hyphenated techniques. Subsequently, immunochemistry techniques will be reviewed in their capability to expand the scope of ICP-MS enabling analysis of a large range of biomolecules alongside elements. These methods inspired mass cytometry and imaging mass cytometry and have the potential to transform diagnostics and treatment by offering new paradigms for personalised medicine. Finally, the interlacing of immunochemistry methods, single event analysis, and functional nanomaterials has opened new horizons to design novel bioassays which promise potential as assets for clinical applications and larger screening programs and will be discussed in their capabilities to detect low-level proteins and nucleic acids.

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http://hdl.handle.net/10453/166143