Neisseria species as pathobionts in bronchiectasis.
Li, L
Mac Aogáin, M
Xu, T
Jaggi, TK
Chan, LLY
Qu, J
Wei, L
Liao, S
Cheng, HS
Keir, HR
Dicker, AJ
Tan, KS
De Yun, W
Koh, MS
Ong, TH
Lim, AYH
Abisheganaden, JA
Low, TB
Hassan, TM
Long, X
Wark, PAB
Oliver, B
Drautz-Moses, DI
Schuster, SC
Tan, NS
Fang, M
Chalmers, JD
Chotirmall, SH
- Publisher:
- CELL PRESS
- Publication Type:
- Journal Article
- Citation:
- Cell Host Microbe, 2022, 30, (9), pp. 1311-1327.e8
- Issue Date:
- 2022-09-14
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Li, L | |
dc.contributor.author | Mac Aogáin, M | |
dc.contributor.author | Xu, T | |
dc.contributor.author | Jaggi, TK | |
dc.contributor.author | Chan, LLY | |
dc.contributor.author | Qu, J | |
dc.contributor.author | Wei, L | |
dc.contributor.author | Liao, S | |
dc.contributor.author | Cheng, HS | |
dc.contributor.author | Keir, HR | |
dc.contributor.author | Dicker, AJ | |
dc.contributor.author | Tan, KS | |
dc.contributor.author | De Yun, W | |
dc.contributor.author | Koh, MS | |
dc.contributor.author | Ong, TH | |
dc.contributor.author | Lim, AYH | |
dc.contributor.author | Abisheganaden, JA | |
dc.contributor.author | Low, TB | |
dc.contributor.author | Hassan, TM | |
dc.contributor.author | Long, X | |
dc.contributor.author | Wark, PAB | |
dc.contributor.author |
Oliver, B |
|
dc.contributor.author | Drautz-Moses, DI | |
dc.contributor.author | Schuster, SC | |
dc.contributor.author | Tan, NS | |
dc.contributor.author | Fang, M | |
dc.contributor.author | Chalmers, JD | |
dc.contributor.author | Chotirmall, SH | |
dc.date.accessioned | 2023-02-16T23:46:31Z | |
dc.date.available | 2022-07-18 | |
dc.date.available | 2023-02-16T23:46:31Z | |
dc.date.issued | 2022-09-14 | |
dc.identifier.citation | Cell Host Microbe, 2022, 30, (9), pp. 1311-1327.e8 | |
dc.identifier.issn | 1931-3128 | |
dc.identifier.issn | 1934-6069 | |
dc.identifier.uri | http://hdl.handle.net/10453/166215 | |
dc.description.abstract | Neisseria species are frequently identified in the bronchiectasis microbiome, but they are regarded as respiratory commensals. Using a combination of human cohorts, next-generation sequencing, systems biology, and animal models, we show that bronchiectasis bacteriomes defined by the presence of Neisseria spp. associate with poor clinical outcomes, including exacerbations. Neisseria subflava cultivated from bronchiectasis patients promotes the loss of epithelial integrity and inflammation in primary epithelial cells. In vivo animal models of Neisseria subflava infection and metabolipidome analysis highlight immunoinflammatory functional gene clusters and provide evidence for pulmonary inflammation. The murine metabolipidomic data were validated with human Neisseria-dominant bronchiectasis samples and compared with disease in which Pseudomonas-, an established bronchiectasis pathogen, is dominant. Metagenomic surveillance of Neisseria across various respiratory disorders reveals broader importance, and the assessment of the home environment in bronchiectasis implies potential environmental sources of exposure. Thus, we identify Neisseria species as pathobionts in bronchiectasis, allowing for improved risk stratification in this high-risk group. | |
dc.format | ||
dc.language | eng | |
dc.publisher | CELL PRESS | |
dc.relation.ispartof | Cell Host Microbe | |
dc.relation.isbasedon | 10.1016/j.chom.2022.08.005 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 0605 Microbiology, 1108 Medical Microbiology | |
dc.subject.classification | Immunology | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Bronchiectasis | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Metagenome | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Microbiota | |
dc.subject.mesh | Neisseria | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Neisseria | |
dc.subject.mesh | Bronchiectasis | |
dc.subject.mesh | Metagenome | |
dc.subject.mesh | Microbiota | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Bronchiectasis | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Metagenome | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Microbiota | |
dc.subject.mesh | Neisseria | |
dc.title | Neisseria species as pathobionts in bronchiectasis. | |
dc.type | Journal Article | |
utslib.citation.volume | 30 | |
utslib.location.activity | United States | |
utslib.for | 0605 Microbiology | |
utslib.for | 1108 Medical Microbiology | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
pubs.organisational-group | /University of Technology Sydney/Centre for Health Technologies (CHT) | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2023-02-16T23:46:29Z | |
pubs.issue | 9 | |
pubs.publication-status | Published | |
pubs.volume | 30 | |
utslib.citation.issue | 9 |
Abstract:
Neisseria species are frequently identified in the bronchiectasis microbiome, but they are regarded as respiratory commensals. Using a combination of human cohorts, next-generation sequencing, systems biology, and animal models, we show that bronchiectasis bacteriomes defined by the presence of Neisseria spp. associate with poor clinical outcomes, including exacerbations. Neisseria subflava cultivated from bronchiectasis patients promotes the loss of epithelial integrity and inflammation in primary epithelial cells. In vivo animal models of Neisseria subflava infection and metabolipidome analysis highlight immunoinflammatory functional gene clusters and provide evidence for pulmonary inflammation. The murine metabolipidomic data were validated with human Neisseria-dominant bronchiectasis samples and compared with disease in which Pseudomonas-, an established bronchiectasis pathogen, is dominant. Metagenomic surveillance of Neisseria across various respiratory disorders reveals broader importance, and the assessment of the home environment in bronchiectasis implies potential environmental sources of exposure. Thus, we identify Neisseria species as pathobionts in bronchiectasis, allowing for improved risk stratification in this high-risk group.
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