Intelligence benefit of the 3-methoxytyramine to tyramine ratio in equine urine.

Elbourne, M; Cawley, A; Stanley, S; Bowen, C; Fu, S

Intelligence benefit of the 3-methoxytyramine to tyramine ratio in equine urine.

Elbourne, M Cawley, A Stanley, S Bowen, C Fu, S

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: Drug Test Anal, 2022, 14, (5), pp. 936-942
Issue Date:: 2022-05

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Field	Value	Language
dc.contributor.author	Elbourne, M
dc.contributor.author	Cawley, A
dc.contributor.author	Stanley, S
dc.contributor.author	Bowen, C
dc.contributor.author	Fu, S https://orcid.org/0000-0002-6238-3612
dc.date.accessioned	2023-02-17T00:19:08Z
dc.date.available	2022-03-21
dc.date.available	2023-02-17T00:19:08Z
dc.date.issued	2022-05
dc.identifier.citation	Drug Test Anal, 2022, 14, (5), pp. 936-942
dc.identifier.issn	1942-7603
dc.identifier.issn	1942-7611
dc.identifier.uri	http://hdl.handle.net/10453/166219
dc.description.abstract	Equine urine analysis has evolved over time to detect thousands of urinary compounds for doping control in the horse racing industry. The longitudinal assessment of 3-methoxytyramine to tyramine ratio (3-MT/T) values in equine urine by GC-MS profiling was investigated to support the Racing NSW Equine Biological Passport (EBP) for detection of dopaminergic manipulation in racehorses. This involved comparison of routine urine samples to administration studies of Sinemet, a common Parkinson's disease medication containing levodopa. Using an endogenous reference compound (ERC) in a urinary ratio enabled greater confidence to provide intelligence of pharmaceutical manipulation as distinct from physiological variation. Population reference limits (PRLs) of 776 ng/ml for urinary 3-MT and 5.3 for 3-MT/T, together with the use of individual reference limits (IRLs), are proposed.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY
dc.relation.ispartof	Drug Test Anal
dc.relation.isbasedon	10.1002/dta.3264
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	0301 Analytical Chemistry, 0601 Biochemistry and Cell Biology, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Analytical Chemistry
dc.subject.mesh	Animals
dc.subject.mesh	Dopamine
dc.subject.mesh	Doping in Sports
dc.subject.mesh	Horses
dc.subject.mesh	Intelligence
dc.subject.mesh	Tyramine
dc.subject.mesh	Urinalysis
dc.subject.mesh	Animals
dc.subject.mesh	Horses
dc.subject.mesh	Dopamine
dc.subject.mesh	Tyramine
dc.subject.mesh	Urinalysis
dc.subject.mesh	Intelligence
dc.subject.mesh	Doping in Sports
dc.subject.mesh	Animals
dc.subject.mesh	Dopamine
dc.subject.mesh	Doping in Sports
dc.subject.mesh	Horses
dc.subject.mesh	Intelligence
dc.subject.mesh	Tyramine
dc.subject.mesh	Urinalysis
dc.title	Intelligence benefit of the 3-methoxytyramine to tyramine ratio in equine urine.
dc.type	Journal Article
utslib.citation.volume	14
utslib.location.activity	England
utslib.for	0301 Analytical Chemistry
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2023-05-01T00:00:00+1000Z
dc.date.updated	2023-02-17T00:19:07Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	14
utslib.citation.issue	5

Abstract:

Equine urine analysis has evolved over time to detect thousands of urinary compounds for doping control in the horse racing industry. The longitudinal assessment of 3-methoxytyramine to tyramine ratio (3-MT/T) values in equine urine by GC-MS profiling was investigated to support the Racing NSW Equine Biological Passport (EBP) for detection of dopaminergic manipulation in racehorses. This involved comparison of routine urine samples to administration studies of Sinemet, a common Parkinson's disease medication containing levodopa. Using an endogenous reference compound (ERC) in a urinary ratio enabled greater confidence to provide intelligence of pharmaceutical manipulation as distinct from physiological variation. Population reference limits (PRLs) of 776 ng/ml for urinary 3-MT and 5.3 for 3-MT/T, together with the use of individual reference limits (IRLs), are proposed.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/166219