Australia as a global sink for the genetic diversity of avian influenza A virus.

Wille, M; Grillo, V; Ban de Gouvea Pedroso, S; Burgess, GW; Crawley, A; Dickason, C; Hansbro, PM; Hoque, MA; Horwood, PF; Kirkland, PD; Kung, NY-H; Lynch, SE; Martin, S; McArthur, M; O'Riley, K; Read, AJ; Warner, S; Hoye, BJ; Lisovski, S; Leen, T; Hurt, AC; Butler, J; Broz, I; Davies, KR; Mileto, P; Neave, MJ; Stevens, V; Breed, AC; Lam, TTY; Holmes, EC; Klaassen, M; Wong, FYK

Australia as a global sink for the genetic diversity of avian influenza A virus.

Wille, M Grillo, V Ban de Gouvea Pedroso, S Burgess, GW Crawley, A Dickason, C Hansbro, PM Hoque, MA Horwood, PF Kirkland, PD Kung, NY-H Lynch, SE Martin, S McArthur, M O'Riley, K Read, AJ Warner, S Hoye, BJ Lisovski, S Leen, T Hurt, AC Butler, J Broz, I Davies, KR Mileto, P Neave, MJ Stevens, V Breed, AC Lam, TTY Holmes, EC Klaassen, M Wong, FYK

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Publisher:: PUBLIC LIBRARY SCIENCE
Publication Type:: Journal Article
Citation:: PLoS Pathog, 2022, 18, (5), pp. e1010150
Issue Date:: 2022-05

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Field	Value	Language
dc.contributor.author	Wille, M
dc.contributor.author	Grillo, V
dc.contributor.author	Ban de Gouvea Pedroso, S
dc.contributor.author	Burgess, GW
dc.contributor.author	Crawley, A
dc.contributor.author	Dickason, C
dc.contributor.author	Hansbro, PM
dc.contributor.author	Hoque, MA
dc.contributor.author	Horwood, PF
dc.contributor.author	Kirkland, PD
dc.contributor.author	Kung, NY-H
dc.contributor.author	Lynch, SE
dc.contributor.author	Martin, S
dc.contributor.author	McArthur, M
dc.contributor.author	O'Riley, K
dc.contributor.author	Read, AJ
dc.contributor.author	Warner, S
dc.contributor.author	Hoye, BJ
dc.contributor.author	Lisovski, S
dc.contributor.author	Leen, T
dc.contributor.author	Hurt, AC
dc.contributor.author	Butler, J
dc.contributor.author	Broz, I
dc.contributor.author	Davies, KR
dc.contributor.author	Mileto, P
dc.contributor.author	Neave, MJ
dc.contributor.author	Stevens, V
dc.contributor.author	Breed, AC
dc.contributor.author	Lam, TTY
dc.contributor.author	Holmes, EC
dc.contributor.author	Klaassen, M
dc.contributor.author	Wong, FYK
dc.contributor.editor	Stern, A
dc.date.accessioned	2023-02-22T04:28:44Z
dc.date.available	2022-03-13
dc.date.available	2023-02-22T04:28:44Z
dc.date.issued	2022-05
dc.identifier.citation	PLoS Pathog, 2022, 18, (5), pp. e1010150
dc.identifier.issn	1553-7366
dc.identifier.issn	1553-7374
dc.identifier.uri	http://hdl.handle.net/10453/166312
dc.description.abstract	Most of our understanding of the ecology and evolution of avian influenza A virus (AIV) in wild birds is derived from studies conducted in the northern hemisphere on waterfowl, with a substantial bias towards dabbling ducks. However, relevant environmental conditions and patterns of avian migration and reproduction are substantially different in the southern hemisphere. Through the sequencing and analysis of 333 unique AIV genomes collected from wild birds collected over 15 years we show that Australia is a global sink for AIV diversity and not integrally linked with the Eurasian gene pool. Rather, AIV are infrequently introduced to Australia, followed by decades of isolated circulation and eventual extinction. The number of co-circulating viral lineages varies per subtype. AIV haemagglutinin (HA) subtypes that are rarely identified at duck-centric study sites (H8-12) had more detected introductions and contemporary co-circulating lineages in Australia. Combined with a lack of duck migration beyond the Australian-Papuan region, these findings suggest introductions by long-distance migratory shorebirds. In addition, on the available data we found no evidence of directional or consistent patterns in virus movement across the Australian continent. This feature corresponds to patterns of bird movement, whereby waterfowl have nomadic and erratic rainfall-dependant distributions rather than consistent intra-continental migratory routes. Finally, we detected high levels of virus gene segment reassortment, with a high diversity of AIV genome constellations across years and locations. These data, in addition to those from other studies in Africa and South America, clearly show that patterns of AIV dynamics in the Southern Hemisphere are distinct from those in the temperate north.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	PUBLIC LIBRARY SCIENCE
dc.relation	http://purl.org/au-research/grants/nhmrc/1175134
dc.relation.ispartof	PLoS Pathog
dc.relation.isbasedon	10.1371/journal.ppat.1010150
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0605 Microbiology, 1107 Immunology, 1108 Medical Microbiology
dc.subject.classification	Virology
dc.subject.mesh	Animals
dc.subject.mesh	Animals, Wild
dc.subject.mesh	Australia
dc.subject.mesh	Birds
dc.subject.mesh	Ducks
dc.subject.mesh	Genetic Variation
dc.subject.mesh	Influenza A virus
dc.subject.mesh	Influenza in Birds
dc.subject.mesh	Phylogeny
dc.subject.mesh	Animals
dc.subject.mesh	Animals, Wild
dc.subject.mesh	Birds
dc.subject.mesh	Ducks
dc.subject.mesh	Influenza A virus
dc.subject.mesh	Phylogeny
dc.subject.mesh	Australia
dc.subject.mesh	Influenza in Birds
dc.subject.mesh	Genetic Variation
dc.subject.mesh	Animals
dc.subject.mesh	Animals, Wild
dc.subject.mesh	Australia
dc.subject.mesh	Birds
dc.subject.mesh	Ducks
dc.subject.mesh	Genetic Variation
dc.subject.mesh	Influenza A virus
dc.subject.mesh	Influenza in Birds
dc.subject.mesh	Phylogeny
dc.title	Australia as a global sink for the genetic diversity of avian influenza A virus.
dc.type	Journal Article
utslib.citation.volume	18
utslib.location.activity	United States
utslib.for	0605 Microbiology
utslib.for	1107 Immunology
utslib.for	1108 Medical Microbiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFI - Centre for Inflammation
utslib.copyright.status	open_access	*
dc.date.updated	2023-02-22T04:28:39Z
pubs.issue	5
pubs.publication-status	Published online
pubs.volume	18
utslib.citation.issue	5

Abstract:

Most of our understanding of the ecology and evolution of avian influenza A virus (AIV) in wild birds is derived from studies conducted in the northern hemisphere on waterfowl, with a substantial bias towards dabbling ducks. However, relevant environmental conditions and patterns of avian migration and reproduction are substantially different in the southern hemisphere. Through the sequencing and analysis of 333 unique AIV genomes collected from wild birds collected over 15 years we show that Australia is a global sink for AIV diversity and not integrally linked with the Eurasian gene pool. Rather, AIV are infrequently introduced to Australia, followed by decades of isolated circulation and eventual extinction. The number of co-circulating viral lineages varies per subtype. AIV haemagglutinin (HA) subtypes that are rarely identified at duck-centric study sites (H8-12) had more detected introductions and contemporary co-circulating lineages in Australia. Combined with a lack of duck migration beyond the Australian-Papuan region, these findings suggest introductions by long-distance migratory shorebirds. In addition, on the available data we found no evidence of directional or consistent patterns in virus movement across the Australian continent. This feature corresponds to patterns of bird movement, whereby waterfowl have nomadic and erratic rainfall-dependant distributions rather than consistent intra-continental migratory routes. Finally, we detected high levels of virus gene segment reassortment, with a high diversity of AIV genome constellations across years and locations. These data, in addition to those from other studies in Africa and South America, clearly show that patterns of AIV dynamics in the Southern Hemisphere are distinct from those in the temperate north.

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http://hdl.handle.net/10453/166312