Aminopeptidases of malaria parasites: New targets for chemotherapy

Trenholme, KR; Brown, CL; Skinner-Adams, TS; Stack, C; Lowther, J; To, J; Robinson, MW; Donnelly, SM; Dalton, JP; Gardiner, DL

Aminopeptidases of malaria parasites: New targets for chemotherapy

Trenholme, KR Brown, CL Skinner-Adams, TS Stack, C Lowther, J To, J

Robinson, MW

Donnelly, SM

Dalton, JP Gardiner, DL

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Publication Type:: Journal Article
Citation:: Infectious Disorders - Drug Targets, 2010, 10 (3), pp. 217 - 225
Issue Date:: 2010-06-25

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Field	Value	Language
dc.contributor.author	Trenholme, KR	en_US
dc.contributor.author	Brown, CL	en_US
dc.contributor.author	Skinner-Adams, TS	en_US
dc.contributor.author	Stack, C	en_US
dc.contributor.author	Lowther, J	en_US
dc.contributor.author	To, J https://orcid.org/0000-0003-3482-4369	en_US
dc.contributor.author	Robinson, MW https://orcid.org/0000-0001-7191-0034	en_US
dc.contributor.author	Donnelly, SM https://orcid.org/0000-0003-2005-3698	en_US
dc.contributor.author	Dalton, JP	en_US
dc.contributor.author	Gardiner, DL	en_US
dc.date.available	2009-11-02	en_US
dc.date.issued	2010-06-25	en_US
dc.identifier.citation	Infectious Disorders - Drug Targets, 2010, 10 (3), pp. 217 - 225	en_US
dc.identifier.issn	1871-5265	en_US
dc.identifier.uri	http://hdl.handle.net/10453/16951
dc.description.abstract	Novel targets for new drug development are urgently required to combat malaria, a disease that puts half of the world's population at risk. One group of enzymes identified within the genome of the most lethal of the causative agents of malaria, Plasmodium falciparum, that may have the potential to become new targets for antimalarial drug development are the aminopeptidases. These enzymes catalyse the cleavage of the N-terminal amino acids from proteins and peptides. P. falciparum appears to encode for at least nine aminopeptidases, two neutral aminopeptidases, one aspartyl aminopeptidase, one aminopeptidase P, one prolyl aminopeptidase and four methionine aminopeptidases. Recent advances in our understanding of these genes and their protein products are outlined in this review, including their potential for antimalarial drug development. © 2010 Bentham Science Publishers Ltd.	en_US
dc.relation.ispartof	Infectious Disorders - Drug Targets	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Plasmodium	en_US
dc.subject.mesh	Plasmodium falciparum	en_US
dc.subject.mesh	Malaria	en_US
dc.subject.mesh	Aminopeptidases	en_US
dc.subject.mesh	Glutamyl Aminopeptidase	en_US
dc.subject.mesh	Protease Inhibitors	en_US
dc.subject.mesh	Antimalarials	en_US
dc.subject.mesh	Methionyl Aminopeptidases	en_US
dc.title	Aminopeptidases of malaria parasites: New targets for chemotherapy	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	10	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1101 Medical Biochemistry and Metabolomics	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	10	en_US

Abstract:

Novel targets for new drug development are urgently required to combat malaria, a disease that puts half of the world's population at risk. One group of enzymes identified within the genome of the most lethal of the causative agents of malaria, Plasmodium falciparum, that may have the potential to become new targets for antimalarial drug development are the aminopeptidases. These enzymes catalyse the cleavage of the N-terminal amino acids from proteins and peptides. P. falciparum appears to encode for at least nine aminopeptidases, two neutral aminopeptidases, one aspartyl aminopeptidase, one aminopeptidase P, one prolyl aminopeptidase and four methionine aminopeptidases. Recent advances in our understanding of these genes and their protein products are outlined in this review, including their potential for antimalarial drug development. © 2010 Bentham Science Publishers Ltd.

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http://hdl.handle.net/10453/16951