Field |
Value |
Language |
dc.contributor.author |
Chen, H
https://orcid.org/0000-0001-6883-3752
|
|
dc.contributor.author |
Burke, C |
|
dc.contributor.author |
Donovan, C |
|
dc.contributor.author |
Faiz, A |
|
dc.contributor.author |
Saad, S |
|
dc.contributor.author |
Oliver, BG |
|
dc.date.accessioned |
2023-04-13T00:40:23Z |
|
dc.date.available |
2023-04-13T00:40:23Z |
|
dc.identifier.citation |
Nutrients, 15, (7), pp. 1783 |
|
dc.identifier.issn |
2072-6643 |
|
dc.identifier.issn |
2072-6643 |
|
dc.identifier.uri |
http://hdl.handle.net/10453/169702
|
|
dc.description.abstract |
<jats:p>Background: The gut microbiome, which can be altered by different diets or smoking, has been implicated in the pathogenesis of lung conditions. E-cigarette vaping is now recognised to have detrimental health effects, with several of these being similar to cigarette smoking. However, whether e-cigarettes can alter high-fat diet (HFD)-induced systemic effects and gut microbiota is unknown. In this study, we investigated the effects of HFD in the absence/presence of e-cigarette exposure on systemic inflammation, lipid metabolic markers, and the gut microbiome. Methods: Mice were fed a HFD (or chow) in the absence/presence of e-vapour exposure (±nicotine) and serum inflammation, lipid levels, and microbial diversity were assessed. Results: HFD increased the circulating levels of both triglycerides and non-esterified fatty acids, which were significantly reduced by e-vapour exposure in HFD-fed mice. Serum TNF-α was increased by HFD consumption or e-vapour. HFD had a significant effect on microbial diversity, but there were no additional effects of e-vapour exposure. Conclusions: This study highlights both similarities and differences in how the body responds to e-cigarette vapours, and it is therefore likely that the long-term sequelae of e-cigarette vapour exposure/vaping might not involve the significant alteration of the gut microbiome.</jats:p> |
|
dc.language |
en |
|
dc.publisher |
MDPI |
|
dc.relation |
http://purl.org/au-research/grants/nhmrc/1158186
|
|
dc.relation |
http://purl.org/au-research/grants/nhmrc/APP1158186
|
|
dc.relation |
http://purl.org/au-research/grants/nhmrc/GNT1158186
|
|
dc.relation.ispartof |
Nutrients |
|
dc.relation.isbasedon |
10.3390/nu15071783 |
|
dc.rights |
info:eu-repo/semantics/openAccess |
|
dc.subject |
0908 Food Sciences, 1111 Nutrition and Dietetics |
|
dc.title |
E-Cigarette Vapour Alters High-Fat Diet-Induced Systemic Inflammatory Responses but Has No Effect on High-Fat Diet-Induced Changes in Gut Microbiota |
|
dc.type |
Journal Article |
|
utslib.citation.volume |
15 |
|
utslib.for |
0908 Food Sciences |
|
utslib.for |
1111 Nutrition and Dietetics |
|
pubs.organisational-group |
/University of Technology Sydney |
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Science |
|
pubs.organisational-group |
/University of Technology Sydney/Strength - CHT - Health Technologies |
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Science/School of Life Sciences |
|
pubs.organisational-group |
/University of Technology Sydney/Centre for Health Technologies (CHT) |
|
utslib.copyright.status |
open_access |
* |
dc.date.updated |
2023-04-13T00:40:22Z |
|
pubs.issue |
7 |
|
pubs.publication-status |
Published online |
|
pubs.volume |
15 |
|
utslib.citation.issue |
7 |
|