Towards Non-Targeted Screening of Lipid Biomarkers for Improved Equine Anti-Doping.
- Publisher:
- MDPI
- Publication Type:
- Journal Article
- Citation:
- Molecules, 2022, 28, (1), pp. 312
- Issue Date:
- 2022-12-30
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Tou, K | |
dc.contributor.author | Cawley, A | |
dc.contributor.author | Bowen, C | |
dc.contributor.author | Bishop, DP | |
dc.contributor.author |
Fu, S https://orcid.org/0000-0002-6238-3612 |
|
dc.date.accessioned | 2023-04-14T12:05:17Z | |
dc.date.available | 2022-12-24 | |
dc.date.available | 2023-04-14T12:05:17Z | |
dc.date.issued | 2022-12-30 | |
dc.identifier.citation | Molecules, 2022, 28, (1), pp. 312 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | http://hdl.handle.net/10453/169799 | |
dc.description.abstract | The current approach to equine anti-doping is focused on the targeted detection of prohibited substances. However, as new substances are rapidly being developed, the need for complimentary methods for monitoring is crucial to ensure the integrity of the racing industry is upheld. Lipidomics is a growing field involved in the characterisation of lipids, their function and metabolism in a biological system. Different lipids have various biological effects throughout the equine system including platelet aggregation and inflammation. A certain class of lipids that are being reviewed are the eicosanoids (inflammatory markers). The use of eicosanoids as a complementary method for monitoring has become increasingly popular with various studies completed to highlight their potential. Studies including various corticosteroids, non-steroidal anti-inflammatories and cannabidiol have been reviewed to highlight the progress lipidomics has had in contributing to the equine anti-doping industry. This review has explored the techniques used to prepare and analyse samples for lipidomic investigations in addition to the statistical analysis and potential for lipidomics to be used for a longitudinal assessment in the equine anti-doping industry. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | MDPI | |
dc.relation.ispartof | Molecules | |
dc.relation.isbasedon | 10.3390/molecules28010312 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry, 0307 Theoretical and Computational Chemistry | |
dc.subject.classification | Organic Chemistry | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Horses | |
dc.subject.mesh | Lipidomics | |
dc.subject.mesh | Inflammation | |
dc.subject.mesh | Lipids | |
dc.subject.mesh | Biomarkers | |
dc.subject.mesh | Eicosanoids | |
dc.subject.mesh | Lipid Metabolism | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Horses | |
dc.subject.mesh | Inflammation | |
dc.subject.mesh | Lipids | |
dc.subject.mesh | Eicosanoids | |
dc.subject.mesh | Lipid Metabolism | |
dc.subject.mesh | Biomarkers | |
dc.subject.mesh | Lipidomics | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Horses | |
dc.subject.mesh | Lipidomics | |
dc.subject.mesh | Inflammation | |
dc.subject.mesh | Lipids | |
dc.subject.mesh | Biomarkers | |
dc.subject.mesh | Eicosanoids | |
dc.subject.mesh | Lipid Metabolism | |
dc.title | Towards Non-Targeted Screening of Lipid Biomarkers for Improved Equine Anti-Doping. | |
dc.type | Journal Article | |
utslib.citation.volume | 28 | |
utslib.location.activity | Switzerland | |
utslib.for | 0304 Medicinal and Biomolecular Chemistry | |
utslib.for | 0305 Organic Chemistry | |
utslib.for | 0307 Theoretical and Computational Chemistry | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Strength - CFS - Centre for Forensic Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2023-04-14T12:05:15Z | |
pubs.issue | 1 | |
pubs.publication-status | Published online | |
pubs.volume | 28 | |
utslib.citation.issue | 1 |
Abstract:
The current approach to equine anti-doping is focused on the targeted detection of prohibited substances. However, as new substances are rapidly being developed, the need for complimentary methods for monitoring is crucial to ensure the integrity of the racing industry is upheld. Lipidomics is a growing field involved in the characterisation of lipids, their function and metabolism in a biological system. Different lipids have various biological effects throughout the equine system including platelet aggregation and inflammation. A certain class of lipids that are being reviewed are the eicosanoids (inflammatory markers). The use of eicosanoids as a complementary method for monitoring has become increasingly popular with various studies completed to highlight their potential. Studies including various corticosteroids, non-steroidal anti-inflammatories and cannabidiol have been reviewed to highlight the progress lipidomics has had in contributing to the equine anti-doping industry. This review has explored the techniques used to prepare and analyse samples for lipidomic investigations in addition to the statistical analysis and potential for lipidomics to be used for a longitudinal assessment in the equine anti-doping industry.
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