Rat-modelled Distribution of Methcathinone and Its Metabolites
- Publication Type:
- Journal Article
- Citation:
- Forensic Science and Technology, 2022, 47, (5), pp. 497-505
- Issue Date:
- 2022-10-01
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| 2022 Yang et al_cathinones_forensic sci technol 2022(05) 497-505.pdf | 94.96 kB |
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An intraperitoneal infection model was here established about methcathinone with rat as the experimental animal, and the distribution of both the drug itself and its metabolites was observed in the rat tissues. SD rats, the selected experimental animal, were divided into three groups that were injected of methcathinone via the intraperitoneal route under the respective dose of 7.6 mg/kg, 15.2 mg/kg and 22.8 mg/kg and successively monitored of their poisoning symptoms. The rats were put to death at 5 min, 15 min and 30 min after drug injection, with their heart, liver, spleen, lung, kidney, brain, stomach, muscle, testicle and heart blood being collected immediately. From the extractions of the above rat tissues, HPLC-MS/MS was to detect the distributed methcathinone and its metabolites: cathinone, ephedrine and pseudoephedrine. Few effects were found of dose on distribution patterns of methcathinone, cathinone, ephedrine and pseudoephedrine among the rat tissues. Kidney was shown of highest concentration for the four tested chemical substances. Within same tissue, methcathinone was always demonstrating highest concentration, leaving cathinone, ephedrine and pseudoephedrine being as the sequential followers. Both methcathinone and cathinone were exceeded over the limit of quantification with the tested blood at each dose, contrasting to ephedrine and pseudoephedrine being under the detection limit any time. The distributed methcathinone was sequentially concentrated as 15 min> 5 min> 30 min, the three time points for rat execution. Nevertheless, cathinone was shown concentrated at the order of 30 min> 15 min> 5 min. Ephedrine and pseudoephedrine were found of mainly distributing in kidney, liver and lungs. Therefore, both methcathinone and its metabolites were distributed in imbalance among the rat tissues. Kidney was of harboring concentration-highest methcathinone, eligible as the sample for forensic identification of abusing methcathinone or relevant poisoning death case.
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